Ultrastructural Morphometrical and Immunocytochemical Analyses of Hepatocyte Nuclei from Mice Fed on Genetically Modified Soybean.
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No direct evidence that genetically modified (GM) food may represent a possible danger for health has been reported so far; however, the scientific literature in this field is still quite poor. Therefore, we carried out an ultrastructural morphometrical and immunocytochemical study on hepatocytes from mice fed on GM soybean, in order to investigate eventual modifications of nuclear components of these cells involved in multiple metabolic pathways related to food processing. Our observations demonstrate significant modifications of some nuclear features in GM-fed mice. In particular, GM fed-mice show irregularly shaped nuclei, which generally represents an index of high metabolic rate, and a higher number of nuclear pores, suggestive of intense molecular trafficking. Moreover, the roundish nucleoli of control animals change in more irregular nucleoli with numerous small fibrillar centres and abundant dense fibrillar component in GM-fed mice, modifications typical of increased metabolic rate. Accordingly, nucleoplasmic (snRNPs and SC-35) and nucleolar (fibrillarin) splicing factors are more abundant in hepatocyte nuclei of GM-fed than in control mice. In conclusion, our data suggest that GM soybean intake can influence hepatocyte nuclear features in young and adult mice; however, the mechanisms responsible for such alterations remain unknown.
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After several months of consumption of an R-tolerant soy, the liver and pancreas of mice were affected, as highlighted by disturbances in sub-nuclear structure.
“After several months of consumption of an R-tolerant soy, the liver and pancreas of mice were affected, as highlighted by disturbances in sub-nuclear structure [12–14].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [13]
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Cijvat, E., Nilsson, H. T., & Huisingh, D. (2007)
- Authors
- Malatesta, M., Caporaloni, C., Gavaudan, S., Rocchi, M. B. L., Serafini, S., Tiberi, C., & Gazzanelli, G.
- Affiliations
- University of Urbino (IT)
- Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche (IT)
- Venue
- Cell Structure and Function
- Publisher
- Japan Society for Cell Biology
- Published
- 2002
- Volume
- 27
- Issue
- 4
- Pages
- 173-180
- ISSN
- 0386-7196 (ISSN-L)
- 1347-3700
- OpenAlex
- W2106517087
- Cited by
- 112
- References
- 29
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 13 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 4
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- transgenic soybean, hepatocyte nuclei, nuclear ultrastructure, nuclear morphometry, nuclear pores, nucleolus, fibrillarin, small nuclear ribonucleoproteins, splicing factors, metabolic rate, GM food safety, mice
- MeSH terms
- Aging, Alanine Transaminase, Animals, Aspartate Aminotransferases, Body Weight, Cell Nucleolus, Cell Nucleus, Chromosomal Proteins, Non-Histone, Female, Golgi Apparatus, Immunohistochemistry, Nuclear Envelope, Glycine max, Ribonucleoproteins, Small Nuclear, Endoplasmic Reticulum, Rough, Nuclear Pore, Secretory Vesicles, Hepatocytes, Food, Genetically Modified, Mice
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