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Cited by 330Visual perception and processing mechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Homeostatic Regulation of Eye-Specific Responses in Visual Cortex during Ocular Dominance Plasticity

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Mrsic-Flogel, Thomas D., Hofer, Sonja B., Ohki, Kenichi, Reid, R. Clay, Bonhoeffer, Tobias, Hübener, Mark·2007·Neuron
DOI 10.1016/j.neuron.2007.05.028
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Abstract

Experience-dependent plasticity is crucial for the precise formation of neuronal connections during development. It is generally thought to depend on Hebbian forms of synaptic plasticity. In addition, neurons possess other, homeostatic means of compensating for changes in sensory input, but their role in cortical plasticity is unclear. We used two-photon calcium imaging to investigate whether homeostatic response regulation contributes to changes of eye-specific responsiveness after monocular deprivation (MD) in mouse visual cortex. Short MD durations decreased deprived-eye responses in neurons with binocular input. Longer MD periods strengthened open-eye responses, and surprisingly, also increased deprived-eye responses in neurons devoid of open-eye input. These bidirectional response adjustments effectively preserved the net visual drive for each neuron. Our finding that deprived-eye responses were either weaker or stronger after MD, depending on the amount of open-eye input a cell received, argues for both Hebbian and homeostatic mechanisms regulating neuronal responsiveness during experience-dependent plasticity.

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  • When one eye is deprived of patterned vision during the classical critical period using lid suture, cortical neurons rapidly (within 2 or 3 days) lose responsiveness to the deprived eye, and then more slowly (over 4-6 days) gain responsiveness to the nondeprived eye.

    “When one eye is deprived of patterned vision during the classical critical period (using lid suture) there is a change in the ability of the two eyes to drive neurons within the binocular portion of visual cortex: cortical neurons rapidly (within 2 or 3 days) lose responsiveness to the deprived eye, and then more slowly (over 4 -6 days) gain responsiveness to the nondeprived eye (Frenkel and Bear”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Mrsic-Flogel et al. 2007

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  • A role for homeostatic plasticity has been suggested to contribute to ocular dominance plasticity in rodent visual cortex.

    “A role for homeostatic plasticity has recently been suggested to contribute to ocular dominance plasticity in rodent visual cortex (Mrsic-Flogel et al. 2007;Kaneko et al. 2008).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Mrsic-Flogel et al. 2007

  • Binocularly driven neurons maintain a similar average level of combined responsiveness to the two eyes, suggesting the drop in deprived eye responsiveness is compensated by an increase in nondeprived eye responsiveness.

    “Interestingly, binocularly driven neurons maintained a similar average level of combined responsiveness to the two eyes, suggesting that the drop in deprived eye responsiveness was compensated by an increase in nondeprived eye responsiveness (Mrsic-Flogel et al. 2007); a very similar response homeostasis following visual deprivation has been reported at retinotectal synapses (Chandrasekaran et al.”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Mrsic-Flogel et al. 2007

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  1. [1]1. Abraham, W.C. ∙ Bear, M.F. Metaplasticity: the plasticity of synaptic plasticity Trends Neurosci. 1996; 19:126-130

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Authors
Mrsic-Flogel, T. D., Hofer, S. B., Ohki, K., Reid, R. C., Bonhoeffer, T., & Hübener, M.
Affiliations
  • Max Planck Society (DE)
  • Harvard University (US)
Corresponding author
Hübener, Mark
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2007-06
Volume
54
Issue
6
Pages
961-972
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2007.05.028
OpenAlex
W2097532290
Cited by
330
References
5
Citations by year
2026: 2 · 2025: 14 · 2024: 5 · 2023: 18 · 2022: 13 · 2021: 7 · 2020: 12 · 2019: 15 · 2018: 15 · 2017: 16 · 2016: 7 · 2015: 16 · 2014: 23 · 2013: 33 · 2012: 24
FWCI
13.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • National Institutes of Health
  • Max-Planck-Gesellschaft
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
homeostatic regulation, ocular dominance plasticity, experience-dependent plasticity, visual cortex, monocular deprivation, Hebbian plasticity, binocular neurons, mouse visual cortex
MeSH terms
Action Potentials, Animals, Animals, Newborn, Brain Mapping, Calcium, Eye, Eyelids, Mice, Inbred C57BL, Neuronal Plasticity, Neurons, Photic Stimulation, Sensory Deprivation, Time Factors, Visual Cortex, Visual Pathways, Vision, Binocular, Vision, Monocular, Dominance, Ocular, Mice

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