Franklin, Robin J. M.

Ageing and multiple sclerosis

Graves, J. S., Krysko, K. M., Hua, L. H., Absinta, M., Franklin, R. J. M., & Segal, B. M. (2023) · The Lancet Neurology

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 260

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination

Chong, S. Y. C., Rosenberg, S. S., Fancy, S. P. J., Zhao, C., Shen, Y.-A. A., Hahn, A. T., McGee, A. W., Xu, X., Zheng, B., Zhang, L. I., et al. (2012) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 232

Quantifying the early stages of remyelination following cuprizone-induced demyelination

Stidworthy, M. F., Genoud, S., Suter, U., Mantei, N., & Franklin, R. J. M. (2003) · Brain Pathology

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 224

Olig gene function in CNS development and disease

Ligon, K. L., Fancy, S. P. J., Franklin, R. J. M., & Rowitch, D. H. (2006) · Glia

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 223

A Map of Transcriptional Heterogeneity and Regulatory Variation in Human Microglia

Young, A. M. H., Kumasaka, N., Calvert, F., Hammond, T. R., Knights, A., Panousis, N., Park, J. S., Schwartzentruber, J., Liu, J., Kundu, K., et al. (2021) · Nature Genetics

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 213

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling

Baer, A. S., Syed, Y. A., Kang, S. U., Mitteregger, D., Vig, R., ffrench-Constant, C., Franklin, R. J. M., Altmann, F., Lubec, G., & Kotter, M. R. (2009) · Brain

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 211

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities

Franklin, R. J. M., & Simons, M. (2022) · Neuron

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 184

The translational biology of remyelination: past, present, and future

Franklin, R. J. M., & Gallo, V. (2014) · Glia

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 162

Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin

Franklin, R. J. M., Frisén, J., & Lyons, D. A. (2021) · Seminars in Cell & Developmental Biology

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 154

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Rawji, K. S., Young, A. M. H., Ghosh, T., Michaels, N. J., Mirzaei, R., Kappen, J., Kolehmainen, K. L., Alaeiilkhchi, N., Lozinski, B., Mishra, M. K., et al. (2020) · Acta Neuropathologica

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 153

Genetically Induced Adult Oligodendrocyte Cell Death Is Associated with Poor Myelin Clearance, Reduced Remyelination, and Axonal Damage

Pohl, H. B. F., Porcheri, C., Mueggler, T., Bachmann, L. C., Martino, G., Riethmacher, D., Franklin, R. J. M., Rudin, M., & Suter, U. (2011) · The Journal of Neuroscience

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 145

Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS

Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K.-A., Franklin, R. J. M., Brakebusch, C., Suter, U., & Relvas, J. B. (2006) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 142

Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination

Zhao, C., Li, W.-W., & Franklin, R. J. M. (2006) · Neurobiology of Aging

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 142

Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis

Anderson, J. M., Hampton, D. W., Patani, R., Pryce, G., Crowther, R. A., Reynolds, R., Franklin, R. J. M., Giovannoni, G., Compston, D. A. S., Baker, D., et al. (2008) · Brain

Multiple Sclerosis Research StudiesAlzheimer's disease research and treatments

Cited by 141

Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS

LI, W., PENDERIS, J., ZHAO, C., SCHUMACHER, M., & FRANKLIN, R. (2006) · Experimental Neurology

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 95

Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination

Yuen, T. J., Johnson, K. R., Miron, V. E., Zhao, C., Quandt, J., Harrisingh, M. C., Swire, M., Williams, A., McFarland, H. F., Franklin, R. J. M., et al. (2013) · Brain

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 80

Stem cells, progenitors and myelin repair

Zhao, C., Fancy, S. P. J., Magy, L., Urwin, J. E., & Franklin, R. J. M. (2005) · Journal of Anatomy

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 61

Inhibition of phosphodiesterase‐4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

Syed, Y. A., Baer, A., Hofer, M. P., González, G. A., Rundle, J., Myrta, S., Huang, J. K., Zhao, C., Rossner, M. J., Trotter, M. W. B., et al. (2013) · EMBO Molecular Medicine

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 58

Transforming growth factor‐beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors

Baror, R., Neumann, B., Segel, M., Chalut, K. J., Fancy, S. P. J., Schafer, D. P., & Franklin, R. J. M. (2019) · Glia

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 54

Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination

Syed, Y. A., Zhao, C., Mahad, D., Möbius, W., Altmann, F., Foss, F., Sentürk, A., Acker-Palmer, A., Lubec, G., Lilley, K., et al. (2016) · Acta Neuropathologica

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 50

Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination

Zhao, C., Fancy, S. P. J., ffrench-Constant, C., & Franklin, R. J. M. (2008) · Neurobiology of Disease

Multiple Sclerosis Research StudiesBone and Dental Protein Studies

Cited by 47

Remyelination in the central nervous system

Franklin, R. J. M., Bodini, B., & Goldman, S. A. (2024) · Cold Spring Harbor Perspectives in Biology

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 40

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination

McMurran, C. E., Guzman de la Fuente, A., Penalva, R., Ben Menachem-Zidon, O., Dombrowski, Y., Falconer, J., Gonzalez, G. A., Zhao, C., Krause, F. N., Young, A. M. H., et al. (2019) · Proceedings of the National Academy of Sciences

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 39

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis

Hampton, D. W., Serio, A., Pryce, G., Al-Izki, S., Franklin, R. J., Giovannoni, G., Baker, D., & Chandran, S. (2013) · Acta Neuropathologica Communications

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 34