Kapitein, Lukas C.

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

Kapitein, L. C., Peterman, E. J. G., Kwok, B. H., Kim, J. H., Kapoor, T. M., & Schmidt, C. F. (2005) · Nature

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 678

Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity

Jaworski, J., Kapitein, L. C., Gouveia, S. M., Dortland, B. R., Wulf, P. S., Grigoriev, I., Camera, P., Spangler, S. A., Di Stefano, P., Demmers, J., et al. (2009) · Neuron

Neuroscience and Neuropharmacology ResearchMicrotubule and mitosis dynamics

Cited by 643

TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites

van Spronsen, M., Mikhaylova, M., Lipka, J., Schlager, M. A., van den Heuvel, D. J., Kuijpers, M., Wulf, P. S., Keijzer, N., Demmers, J., Kapitein, L. C., et al. (2013) · Neuron

Microtubule and mitosis dynamicsMitochondrial Function and Pathology

Cited by 450

Mixed microtubules steer dynein-driven cargo transport into dendrites

Kapitein, L. C., Schlager, M. A., Kuijpers, M., Wulf, P. S., van Spronsen, M., MacKintosh, F. C., & Hoogenraad, C. C. (2010) · Current Biology

Microtubule and mitosis dynamicsNeuroscience and Neuropharmacology Research

Cited by 320

Differentiation between oppositely oriented microtubules controls polarized neuronal transport

Tas, R. P., Chazeau, A., Cloin, B. M. C., Lambers, M. L. A., Hoogenraad, C. C., & Kapitein, L. C. (2017) · Neuron

Microtubule and mitosis dynamicsNeurogenesis and neuroplasticity mechanisms

Cited by 306

Mechanisms of microtubule organization in differentiated animal cells

Akhmanova, A., & Kapitein, L. C. (2022) · Nature Reviews Molecular Cell Biology

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 233

TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays

van Beuningen, S. F. B., Will, L., Harterink, M., Chazeau, A., van Battum, E. Y., Frias, C. P., Franker, M. A. M., Katrukha, E. A., Stucchi, R., Vocking, K., et al. (2015) · Neuron

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 225

MAP2 defines a pre-axonal filtering Zone to regulate KIF1- versus KIF5-Dependent cargo transport in sensory neurons

Gumy, L. F., Katrukha, E. A., Grigoriev, I., Jaarsma, D., Kapitein, L. C., Akhmanova, A., & Hoogenraad, C. C. (2017) · Neuron

Microtubule and mitosis dynamicsCellular transport and secretion

Cited by 186

Direct observation of motor protein stepping in living cells using MINFLUX

Deguchi, T., Iwanski, M. K., Schentarra, E.-M., Heidebrecht, C., Schmidt, L., Heck, J., Weihs, T., Schnorrenberg, S., Hoess, P., Liu, S., et al. (2023) · Science

Advanced Fluorescence Microscopy TechniquesMicrotubule and mitosis dynamics

Cited by 167

MAP7 family proteins regulate kinesin-1 recruitment and activation

Hooikaas, P. J., Martin, M., Mühlethaler, T., Kuijntjes, G.-J., Peeters, C. A. E., Katrukha, E. A., Ferrari, L., Stucchi, R., Verhagen, D. G. F., van Riel, W. E., et al. (2019) · Journal of Cell Biology

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 166

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis

Schlager, M. A., Kapitein, L. C., Grigoriev, I., Burzynski, G. M., Wulf, P. S., Keijzer, N., de Graaff, E., Fukuda, M., Shepherd, I. T., Akhmanova, A., et al. (2010) · The EMBO Journal

Cellular transport and secretionMicrotubule and mitosis dynamics

Cited by 165

In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends

Montenegro Gouveia, S., Leslie, K., Kapitein, L. C., Buey, R. M., Grigoriev, I., Wagenbach, M., Smal, I., Meijering, E., Hoogenraad, C. C., Wordeman, L., et al. (2010) · Current Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 147

Microtubule cross-linking triggers the directional motility of kinesin-5

Kapitein, L. C., Kwok, B. H., Weinger, J. S., Schmidt, C. F., Kapoor, T. M., & Peterman, E. J. G. (2008) · The Journal of Cell Biology

Microtubule and mitosis dynamicsAdvanced Fluorescence Microscopy Techniques

Cited by 143

Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity

Kevenaar, J. T., Bianchi, S., van Spronsen, M., Olieric, N., Lipka, J., Frias, C. P., Mikhaylova, M., Harterink, M., Keijzer, N., Wulf, P. S., et al. (2016) · Current Biology

Microtubule and mitosis dynamicsHereditary Neurological Disorders

Cited by 110

Allosteric inhibition of kinesin-5 modulates its processive directional motility

Kwok, B. H., Kapitein, L. C., Kim, J. H., Peterman, E. J. G., Schmidt, C. F., & Kapoor, T. M. (2006) · Nature Chemical Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 108

Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

Serra-Marques, A., Martin, M., Katrukha, E. A., Grigoriev, I., Peeters, C. A., Liu, Q., Hooikaas, P. J., Yao, Y., Solianova, V., Smal, I., et al. (2020) · eLife

Microtubule and mitosis dynamicsCellular transport and secretion

Cited by 93

Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots

Katrukha, E. A., Mikhaylova, M., van Brakel, H. X., van Bergen en Henegouwen, P. M., Akhmanova, A., Hoogenraad, C. C., & Kapitein, L. C. (2017) · Nature Communications

Microtubule and mitosis dynamicsQuantum Dots Synthesis And Properties

Cited by 80

Quantitative mapping of dense microtubule arrays in mammalian neurons

Katrukha, E. A., Jurriens, D., Salas Pastene, D. M., & Kapitein, L. C. (2021) · eLife

Microtubule and mitosis dynamicsAdvanced Fluorescence Microscopy Techniques

Cited by 74

Barriers in the brain: resolving dendritic spine morphology and compartmentalization

Adrian, M., Kusters, R., Wierenga, C. J., Storm, C., Hoogenraad, C. C., & Kapitein, L. C. (2014) · Frontiers in Neuroanatomy

Neuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Cited by 62

Shape-induced asymmetric diffusion in dendritic spines allows efficient synaptic AMPA receptor trapping

Kusters, R., Kapitein, L. C., Hoogenraad, C. C., & Storm, C. (2013) · Biophysical Journal

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 53

Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions

Koppers, M., Özkan, N., Nguyen, H. H., Jurriens, D., McCaughey, J., Nguyen, D. T. M., Li, C. H., Stucchi, R., Altelaar, M., MacGillavry, H. D., et al. (2024) · Developmental Cell

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 44

Axonal ER tubules regulate local translation via P180/RRBP1-mediated ribosome interactions

Koppers, M., Özkan, N., Nguyen, H. H., Jurriens, D., McCaughey, J., Stucchi, R., Altelaar, M., Kapitein, L. C., Hoogenraad, C. C., & Farias, G. G. (2022) · Developmental Cell

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 44

A live-cell marker to visualize the dynamics of stable microtubules throughout the cell cycle

Jansen, K. I., Iwanski, M. K., Burute, M., & Kapitein, L. C. (2023) · Journal of Cell Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 39

Lattice defects induced by microtubule-stabilizing agents exert a long-range effect on microtubule growth by promoting catastrophes

Rai, A., Liu, T., Katrukha, E. A., Estévez-Gallego, J., Manka, S. W., Paterson, I., Díaz, J. F., Kapitein, L. C., Moores, C. A., & Akhmanova, A. (2021) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 38