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Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization

Anis, O., Vinayaka, A. C., Shalev, N., Namdar, D., Nadarajan, S., Anil, S. M., Cohen, O., Belausov, E., Ramon, J., Gati, E. M., et al. (2021) · Molecules · doi:10.3390/molecules26020465 · Cited by 61 · see citing works

Involvement of the endocannabinoid system in osteoarthritis pain

Porta, C. L., Bura, S. A., Negrete, R., & Maldonado, R. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12468 · Cited by 61 · see citing works

The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice

Sophocleous, A., Börjesson, A. E., Salter, D. M., & Ralston, S. H. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.04.020 · Cited by 54 · see citing works

Endogenous opiates and behavior: 2013

Bodnar, R. J. (2014) · Peptides · doi:10.1016/j.peptides.2014.09.013 · Cited by 52 · see citing works

Inhibition of GABAergic Neurons and Excitation of Glutamatergic Neurons in the Ventrolateral Periaqueductal Gray Participate in Electroacupuncture Analgesia Mediated by Cannabinoid Receptor

Zhu, H., Xiang, H.-C., Li, H., Lin, L., Hu, X., Zhang, H., Meng, W., Liu, L., Chen, C., Shu, Y., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00484 · Cited by 52 · see citing works

Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems—A Novel Treatment Option for Chronic Pain Management

Małek, N., & Starowicz, K. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00257 · Cited by 51 · see citing works

Electroacupuncture Potentiates Cannabinoid Receptor-Mediated Descending Inhibitory Control in a Mouse Model of Knee Osteoarthritis

Yuan, X.-C., Zhu, B., Jing, X.-H., Xiong, L., Wu, C.-H., Gao, F., Li, H., Xiang, H.-C., Zhu, H., Zhou, B., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00112 · Cited by 52 · see citing works

Cannabinoid Receptors and Their Relationship With Chronic Pain: A Narrative Review

Anthony, A. T., Rahmat, S., Sangle, P., Sandhu, O., & Khan, S. (2020) · Cureus · doi:10.7759/cureus.10436 · Cited by 45 · see citing works

Microglial Cannabinoid CB2 Receptors in Pain Modulation

Xu, K., Wu, Y., Tian, Z., Xu, Y., Wu, C., & Wang, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032348 · Cited by 41 · see citing works

Role of CB2 receptors in social and aggressive behavior in male mice

Rodríguez‐Arias, M., Navarrete, F., Blanco-Gandía, M. C., Arenas, M. C., Aguilar, M. A., Bartoll-Andrés, A., Valverde, O., Miñarro, J., & Manzanares, J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3939-5 · Cited by 41 · see citing works

Cannabinoids in Chronic Pain: Therapeutic Potential Through Microglia Modulation

van den Hoogen, N. J., Harding, E. K., Davidson, C. E. D., & Trang, T. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.816747 · Cited by 45 · see citing works

Sigma‐1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain

Carcolé, M., Kummer, S., Gonçalves, L., Zamanillo, D., Merlos, M., Dickenson, A. H., Fernández‐Pastor, B., Cabañero, D., & Maldonado, R. J. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14794 · Cited by 39 · see citing works

Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review

Bryk, M., & Starowicz, K. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00270-y · Cited by 40 · see citing works

Electroacupuncture potentiates peripheral CB2 receptor-inhibited chronic pain in a mouse model of knee osteoarthritis

Yuan, X., Wang, Q., Su, W., Li, H., Wu, C., Gao, F., Xiang, H.-C., Zhu, H., Lin, L., Hu, X., et al. (2018) · Journal of Pain Research · doi:10.2147/jpr.s171664 · Cited by 39 · see citing works

Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

Zhu, C., Lan, X., Wei, Z., Yu, J., & Zhang, J. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.020 · Cited by 37 · see citing works

Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice

Negrete, R., García‐Gutiérrez, M. S., Manzanares, J., & Maldonado, R. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.026 · Cited by 36 · see citing works

Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord

Xu, Y., Jiang, Y., Wang, L., Huang, J., Wen, J., Lv, H., Wu, X., Wan, C., Yu, C., Zhang, W., et al. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00346-z · Cited by 32 · see citing works

CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development

Mlost, J., Kostrzewa, M., Borczyk, M., Bryk, M., Chwastek, J., Korostyński, M., & Starowicz, K. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111283 · Cited by 32 · see citing works

Chronic Cannabigerol as an Effective Therapeutic for Cisplatin-Induced Neuropathic Pain

Nachnani, R., Sepúlveda, D. E., Booth, J. L., Zhou, S., Graziane, N., Raup‐Konsavage, W. M., & Vrana, K. E. (2023) · Pharmaceuticals · doi:10.3390/ph16101442 · Cited by 27 · see citing works

Genetic Manipulation of the Endocannabinoid System

Zimmer, A. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_5 · Cited by 26 · see citing works

Cannabinoid receptor 2‑selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord

Mao, Y., Huang, Y., Zhang, Y., Wang, C., Wu, H., Tian, X., Liu, Y., Hou, B., Liang, Y., Rong, H., et al. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10772 · Cited by 26 · see citing works

Dose‐Dependent Cannabidiol‐Induced Elevation of Intracellular Calcium and Apoptosis in Human Articular Chondrocytes

Winklmayr, M., Gaisberger, M., Kittl, M., Fuchs, J., Ritter, M., & Jakab, M. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24430 · Cited by 25 · see citing works

Turning Down the Thermostat: Modulating the Endocannabinoid System in Ocular Inflammation and Pain

Toguri, J. T., Caldwell, M. D., & Kelly, M. E. M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00304 · Cited by 23 · see citing works

Pain in osteoarthritis from a symptom to a disease

Perrot, S., & Trouvin, A. (2023) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2023.101825 · Cited by 25 · see citing works

Cannabinoids in Health and Disease

Meccariello, R., & Chianese, R. (2016) · InTech eBooks · doi:10.5772/61595 · Cited by 21 · see citing works

Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus

Komorowska‐Müller, J. A., Ravichandran, K. A., Zimmer, A., & Schürmann, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-96285-9 · Cited by 18 · see citing works

Spinal 5-HT 2A receptor is involved in electroacupuncture inhibition of chronic pain

Yuan, X.-C., Wang, Y., Tian, L.-X., Yan, X.-J., Guo, Y.-X., Zhao, Y.-L., Baba, S. S., Jia, H., Wang, H., Li, M., et al. (2022) · Molecular Pain · doi:10.1177/17448069221087583 · Cited by 19 · see citing works

Antinociceptive and chondroprotective effects of prolonged β-caryophyllene treatment in the animal model of osteoarthritis: Focus on tolerance development

Mlost, J., Kac, P. R., Kędziora, M., & Starowicz, K. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108908 · Cited by 19 · see citing works

Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through sirt1 activation

Zhang, D., Zhang, G., Li, Z., & Li, B. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218757950 · Cited by 16 · see citing works

Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain

Garrido‐Suárez, B. B., Garrido, G., Piñeros, O., & Delgado, R. (2019) · Phytotherapy Research · doi:10.1002/ptr.6546 · Cited by 15 · see citing works

Echinacea purpurea against neuropathic pain: Alkamides versus polyphenols efficacy

Micheli, L., Maggini, V., Ciampi, C., Gallo, E. R., Bogani, P., Fani, R., Pistelli, L., Ghelardini, C., Mannelli, L. D. C., Leo, M. D., et al. (2022) · Phytotherapy Research · doi:10.1002/ptr.7709 · Cited by 13 · see citing works

Cannabinoid receptors are expressed in equine synovium and upregulated with synovitis

Miagkoff, L., Girard, C. A., St‐Jean, G., Richard, H., Beauchamp, G., & Laverty, S. (2022) · Equine Veterinary Journal · doi:10.1111/evj.13860 · Cited by 12 · see citing works

Mirror-Image Pain Update: Complex Interactions Between Central and Peripheral Mechanisms

Vlah, V. D., & Bach‐Rojecky, L. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04102-x · Cited by 9 · see citing works

Cannabinoid receptor agonists from Conus venoms alleviate pain-related behavior in rats

Jergová, S., Perez, C., Imperial, J. S., Gajavelli, S., Jain, A., Abin, A., Olivera, B. M., & Sagen, J. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173182 · Cited by 9 · see citing works

Emerging targets and therapeutic approaches for the treatment of osteoarthritis pain

Rahman, W., & Dickenson, A. H. (2015) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000125 · Cited by 9 · see citing works

Therapeutic Effects of Fire Needling Acupuncture on Pain Relief and Cartilage Protection in MIA-Induced Knee Osteoarthritis Rats: The Role of Macrophage Polarization in Synovium and Angiogenesis in Subchondral Bone

Wei, J., Yang, X., Ge, X., Zhao, L., Liu, X., Zhang, J., Zhou, J., Zhang, C., Li, W., Li, Z., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s518829 · Cited by 7 · see citing works

5-HT7 Receptor Is Involved in Electroacupuncture Inhibition of Chronic Pain in the Spinal Cord

Yuan, X., Yan, X.-J., Tian, L.-X., Guo, Y.-X., Zhao, Y.-L., Baba, S. S., Wang, Y., Liang, L., Jia, H., Xu, L., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.733779 · Cited by 7 · see citing works

DDD-028: A potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain

Rajagopalan, P., Tracey, H., Chen, Z., Bandyopadhyaya, A., Veeraraghavan, S., Rajagopalan, D. R., Salvemini, D., McPhee, I., Viswanadha, S., & Rajagopalan, R. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.05.016 · Cited by 7 · see citing works

Imaging and Genetic Tools for the Investigation of the Endocannabinoid System in the CNS

Kouchaeknejad, A., van der Walt, G., de Donato, M. H., & Puighermanal, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115829 · Cited by 6 · see citing works

Inhibition of synaptic transmission by anandamide precursor 20:4-NAPE is mediated by TRPV1 receptors under inflammatory conditions

Spicarova, D., Nerandžič, V., Muzik, D., Pontearso, M., Bhattacharya, A., Nagy, I., & Paleček, J. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1188503 · Cited by 5 · see citing works

Hemoglobin α-derived peptides VD-hemopressin (α) and RVD-hemopressin (α) are involved in electroacupuncture inhibition of chronic pain

Yuan, X., Guo, Y., Yi, H., Hou, X., Zhao, Y., Wang, Y., Jia, H., Baba, S. S., Li, M., & Huo, F.-Q. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1439448 · Cited by 3 · see citing works

Cannabinoids: Drug or Medication?

Giron, L., & Befort, K. (2016) · InTech eBooks · doi:10.5772/63172 · Cited by 3 · see citing works

The Endocannabinoid System in Local and Systemic Inflammation

Kelly, M. E. M., Lehmann, C., & Zhou, J. (2017) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00151ed1v01y201702isp074 · Cited by 3 · see citing works

Comparative antinociceptive effect of arachidonylcyclopropylamide, a cannabinoid 1 receptor agonist & lignocaine, a local anaesthetic agent, following direct intrawound administration in rats

Kumar, R., Prasoon, P., Gautam, M., & Ray, S. B. (2016) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_1402_15 · Cited by 3 · see citing works

Fatty acid amide hydrolase activity in the dorsal periaqueductal gray attenuates neuropathic pain and associated dysautonomia

Woyach, V. L., Sherman, K., Hillard, C. J., Hopp, F. A., Hogan, Q. H., & Dean, C. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00073.2022 · Cited by 1 · see citing works

Vision actuelle de la douleur arthrosique : comprendre la physiopathologie et l’expérience des patients pour une meilleure prise en charge

Carvès, S., Trouvin, A., & Perrot, S. (2021) · Revue du Rhumatisme Monographies · doi:10.1016/j.monrhu.2021.02.004 · Cited by 1 · see citing works

The Effects of Endocannabinoid Modulation and Neurogenic Inflammation in Experimental Knee Joint Arthritis

Krustev, E. (2015) · DalSpace (Dalhousie University)

The cannabinoid system and its role in nociception

Beltramo, M. (2016) · Wiley eBooks · doi:10.1002/9781118455968.ch6

Douleur dans l’arthrose : comprendre les mécanismes pour améliorer la prise en charge

Trouvin, A., & Perrot, S. (2017) · Revue du Rhumatisme · doi:10.1016/j.rhum.2017.12.002

Traitements controversés : que faut-il en penser ?

Deleens, R., Pickering, G. P., Serrié, A., Perrot, S., Desfontaines, N., & Sichère, P. (2020) · Douleurs Évaluation - Diagnostic - Traitement · doi:10.1016/s1624-5687(20)30085-8

Cannabis et dérivés : usage et mésusage thérapeutique en rhumatologie

Blandin, C., & Perrot, S. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-78249-7.00021-7

Osteoarthritis

O’Brien, K., & Bosak, C. (2025) · Springer eBooks · doi:10.1007/978-3-032-01737-6_8

Endocannabinoid system modulation in acute, chronic, and neuropathic pain: reviewing experimental models, clinical evidence, and nanotechnology delivery

Elgohary, R., & Baraka, S. M. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01862-4

PM289, a synthetic CB2 in vitro receptor agonist, modulates morphine-induced antinociceptive effect and withdrawal syndrome in an animal model of osteoarthritic pain

Martínez-García, M. Á., Paniagua, N., Morales, P., Rodríguez‐Rivera, C., Sánchez-Robles, E., Pascual, D., Herradón, E., Goicoechea, C., Jagerovic, N., & Girón, R. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111090

Sex-specific differences in nociceptive behaviour and the amygdala endocannabinoid system in the rat monoiodoacetate-induced knee osteoarthritis model

Ferdousi, M. I., Infantino, R., Redmond, M. C., Krishnan, S. D., Adjei, C. K., McDermott, B., Liddy, A., Quinlan, L. R., O’Halloran, M., & Finn, D. P. (2026) · Neurobiology of Pain · doi:10.1016/j.ynpai.2026.100227

BindingDB Entry 50045087: DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.

BindingDB (2016) · UC San Diego · doi:10.7270/q28k7bq5

Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

Burston, J. J., Sagar, D. R., Shao, P., Bai, M., King, E., Brailsford, L., Turner, J. M., Hathway, G. J., Bennett, A. J., Walsh, D. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080440 · Cited by 103 · see citing works

Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain

Schuelert, N., Zhang, C., Mogg, A. J., Broad, L. M., Hepburn, D. L., Nisenbaum, E. S., Johnson, M. P., & McDougall, J. J. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.09.005 · Cited by 77 · see citing works

CB2 receptor deletion on myeloid cells enhanced mechanical allodynia in a mouse model of neuropathic pain

Nent, E., Nozaki, C., Schmöle, A., Otte, D. M., & Zimmer, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-43858-4 · Cited by 37 · see citing works

Antinociceptive effects of the non-selective cannabinoid receptor agonist CP 55,940 are absent in CB1(−/−) and not CB2(−/−) mice in models of acute and persistent pain

Sain, N. M. H., Liang, A., Kane, S. A., & Urban, M. O. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.004 · Cited by 51 · see citing works

Nondeterministic individual responses to receptor selective opioid analgesics

Lipkowski, A. W., SILBERT, B. S., Cepeda, M. S., Osgood, P. F., SZYFELBEIN, S. K., & Carr, D. B. (1990) · Pain · doi:10.1016/0304-3959(90)92647-9 · Cited by 1 · see citing works