Auchus, Richard J.

5α-Androstane-3α,17β-diol is formed in tammar wallaby pouch young testes by a pathway involving 5α-pregnane-3α,17α-diol-20-one as a key intermediate

Wilson, J. D., Auchus, R. J., Leihy, M. W., Guryev, O. L., Estabrook, R. W., Osborn, S. M., Shaw, G., & Renfree, M. B. (2003) · Endocrinology

Sperm and Testicular FunctionSexual Differentiation and Disorders

Cited by 172

Structural and functional biology of aldo-keto reductase steroid transforming enzymes

Penning, T. M., Wangtrakuldee, P., & Auchus, R. J. (2019) · Endocrine Reviews

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 164

Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3β-hydroxysteroid dehydrogenase

Arlt, W., Auchus, R. J., & Miller, W. L. (2001) · Journal of Biological Chemistry

Ovarian function and disordersAdrenal Hormones and Disorders

Cited by 157

11-Ketotestosterone is the Dominant Circulating Bioactive Androgen During Normal and Premature Adrenarche

Rege, J., Turcu, A., Kasa-Vubu, J. Z., Lerario, A. M., Auchus, G. C., Auchus, R. J., Smith, J. M., White, P. C., & Rainey, W. E. (2018) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 154

CYP17 mutation E305G causes isolated 17,20 lyase deficiency by selectively altering substrate binding

Sherbet, D. P., Tiosano, D., Kwist, K. M., Hochberg, Z., & Auchus, R. J. (2003) · Journal of Biological Chemistry

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 131

Approach to the patient: the adult with congenital adrenal hyperplasia

Auchus, R. J., & Arlt, W. (2013) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 121

Steroid biosynthesis and prostate cancer

Sharifi, N., & Auchus, R. J. (2012) · Steroids

Prostate Cancer Treatment and ResearchHormonal and reproductive studies

Cited by 116

Randomized trial of osilodrostat for the treatment of Cushing disease

Gadelha, M., Bex, M., Feelders, R. A., Heaney, A. P., Auchus, R. J., Gilis-Januszewska, A., Witek, P., Belaya, Z., Yu, Y., Liao, Z., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism

Pituitary Gland Disorders and TreatmentsAdrenal Hormones and Disorders

Cited by 114

Adrenal Androgens and Androgen Precursors-Definition, Synthesis, Regulation and Physiologic Actions

Turcu, A., Smith, J. M., Auchus, R., & Rainey, W. E. (2014) · Comprehensive physiology

Adrenal Hormones and DisordersHormonal Regulation and Hypertension

Cited by 113

11-oxygenated C19 steroids Do not decline with age in women

Nanba, A. T., Rege, J., Ren, J., Auchus, R. J., Rainey, W. E., & Turcu, A. F. (2019) · The Journal of Clinical Endocrinology & Metabolism

Hormonal and reproductive studiesAdrenal Hormones and Disorders

Cited by 113

Minireview: Cellular Redox State Regulates Hydroxysteroid Dehydrogenase Activity and Intracellular Hormone Potency

Agarwal, A. K., & Auchus, R. J. (2005) · Endocrinology

Steroid Chemistry and BiochemistryEstrogen and related hormone effects

Cited by 112

11-Oxygenated Androgens are Biomarkers of Adrenal Volume and Testicular Adrenal Rest Tumors in 21-Hydroxylase Deficiency

Turcu, A. F., Mallappa, A., Elman, M. S., Avila, N. A., Marko, J., Rao, H., Tsodikov, A., Auchus, R. J., & Merke, D. P. (2017) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 107

Fertility in patients with genetic deficiencies of cytochrome P450c17 (CYP17A1): combined 17-hydroxylase/17,20-lyase deficiency and isolated 17,20-lyase deficiency

Marsh, C. A., & Auchus, R. J. (2014) · Fertility and Sterility

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 103

Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species

Arlt, W., Martens, J. W. M., Song, M., Wang, J. T., Auchus, R. J., & Miller, W. L. (2002) · Endocrinology

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 101

Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial

Fleseriu, M., Pivonello, R., Elenkova, A., Salvatori, R., Auchus, R. J., Feelders, R. A., Geer, E. B., Greenman, Y., Witek, P., Cohen, F., et al. (2019) · The Lancet Diabetes & Endocrinology

Pituitary Gland Disorders and TreatmentsAdrenal Hormones and Disorders

Cited by 101

Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency

Auchus, R. J., Buschur, E. O., Chang, A. Y., Hammer, G. D., Ramm, C., Madrigal, D., Wang, G., Gonzalez, M., Xu, X. S., Smit, J. W., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 97

Molecular Pathways: Inhibiting Steroid Biosynthesis in Prostate Cancer

Ferraldeschi, R., Sharifi, N., Auchus, R. J., & Attard, G. (2013) · Clinical Cancer Research

Prostate Cancer Treatment and ResearchCancer, Lipids, and Metabolism

Cited by 93

The metabolism, analysis, and targeting of steroid hormones in breast and prostate cancer

Capper, C. P., Rae, J. M., & Auchus, R. J. (2016) · Hormones and Cancer

Prostate Cancer Treatment and ResearchEstrogen and related hormone effects

Cited by 89

Sex hormones and prostate cancer

Auchus, R. J., & Sharifi, N. (2020) · Annual Review of Medicine

Prostate Cancer Treatment and ResearchProstate Cancer Diagnosis and Treatment

Cited by 85

“Subclinical Cushing’s syndrome” is not subclinical: improvement after adrenalectomy in 9 patients

Mitchell, I. C., Auchus, R. J., Juneja, K., Chang, A. Y., Holt, S. A., Snyder, W. H., & Nwariaku, F. E. (2007) · Surgery

Adrenal and Paraganglionic TumorsPituitary Gland Disorders and Treatments

Cited by 84

5α-Reduced C21 steroids are substrates for human cytochrome P450c17

Gupta, M. K., Guryev, O. L., & Auchus, R. J. (2003) · Archives of Biochemistry and Biophysics

Steroid Chemistry and BiochemistryAdrenal Hormones and Disorders

Cited by 84

Clinical significance of 11-oxygenated androgens

Turcu, A. F., & Auchus, R. J. (2017) · Current Opinion in Endocrinology, Diabetes & Obesity

Hormonal and reproductive studiesAdrenal Hormones and Disorders

Cited by 80

Profiles of 21-Carbon Steroids in 21-Hydroxylase Deficiency

Turcu, A. F., Rege, J., Chomic, R., Liu, J., Nishimoto, H. K., Else, T., Moraitis, A. G., Palapattu, G. S., Rainey, W. E., & Auchus, R. J. (2015) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 77

Sex differences in 11-oxygenated androgen patterns across adulthood

Davio, A., Woolcock, H., Nanba, A. T., Rege, J., O’Day, P., Ren, J., Zhao, L., Ebina, H., Auchus, R., Rainey, W. E., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism

Hormonal and reproductive studiesAdrenal Hormones and Disorders

Cited by 76