Goldstein, Joseph L.

The two-receptor model of lipoprotein clearance: tests of the hypothesis in “knockout” mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins

Ishibashi, S., Herz, J., Maeda, N., Goldstein, J. L., & Brown, M. S. (1994) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 430

Cholesterol Addition to ER Membranes Alters Conformation of SCAP, the SREBP Escort Protein that Regulates Cholesterol Metabolism

Brown, A. J., Sun, L., Feramisco, J. D., Brown, M. S., & Goldstein, J. L. (2002) · Molecular Cell

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 417

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

Davis, C. G., Goldstein, J. L., Südhof, T. C., Anderson, R. G. W., Russell, D. W., & Brown, M. S. (1987) · Nature

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 411

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence

Briggs, M. R., Yokoyama, C., Wang, X., Brown, M. S., & Goldstein, J. L. (1993) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismGenomics and Chromatin Dynamics

Cited by 401

Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia

Beisiegel, U., Schneider, W. J., Goldstein, J. L., Anderson, R. G., & Brown, M. S. (1981) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 357

Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase

Seabra, M. C., Brown, M. S., & Goldstein, J. L. (1993) · Science

Retinal Development and DisordersCellular transport and secretion

Cited by 337

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

Lu, F., Liang, Q., Abi-Mosleh, L., Das, A., De Brabander, J. K., Goldstein, J. L., & Brown, M. S. (2015) · eLife

Cholesterol and Lipid MetabolismLysosomal Storage Disorders Research

Cited by 333

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

Moon, Y.-A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M. S., Goldstein, J. L., & Horton, J. D. (2012) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 320

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila

Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L., & Rawson, R. B. (2002) · Science

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 318

Receptor-Mediated Uptake of Lipoprotein-Cholesterol and Its Utilization for Steroid Synthesis in the Adrenal Cortex

BROWN, M. S., KOVANEN, P. T., & GOLDSTEIN, J. L. (1979) · Proceedings of the 1978 Laurentian Hormone Conference

Cholesterol and Lipid MetabolismSteroid Chemistry and Biochemistry

Cited by 311

Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.

Schneider, W. J., Kovanen, P. T., Brown, M. S., Goldstein, J. L., Utermann, G., Weber, W., Havel, R. J., Kotite, L., Kane, J. P., Innerarity, T. L., et al. (1981) · Journal of Clinical Investigation

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 310

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product

Seabra, M. C., Brown, M. S., Slaughter, C. A., Südhof, T. C., & Goldstein, J. L. (1992) · Cell

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 300

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization

Wang, X., Briggs, M. R., Hua, X., Yokoyama, C., Goldstein, J. L., & Brown, M. S. (1993) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismGenomics and Chromatin Dynamics

Cited by 299

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

Gong, Y., Lee, J. N., Lee, P. C. W., Goldstein, J. L., Brown, M. S., & Ye, J. (2006) · Cell Metabolism

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 262

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

Frykman, P. K., Brown, M. S., Yamamoto, T., Goldstein, J. L., & Herz, J. (1995) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 256

THE LDL RECEPTOR LOCUS AND THE GENETICS OF FAMILIAL HYPERCHOLESTEROLEMIA

Goldstein, J. L., & Brown, M. S. (1979) · Annual Review of Genetics

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 233

Lowering LDL—not only how low, but how long?

Brown, M. S., & Goldstein, J. L. (2006) · Science

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 204

The SREBP Pathway in Drosophila

Seegmiller, A. C., Dobrosotskaya, I., Goldstein, J. L., Ho, Y. K., Brown, M. S., & Rawson, R. B. (2002) · Developmental Cell

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 194

Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors

Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S., & Goldstein, J. L. (1990) · Science

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 175

Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts

Bersot, T. P., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1976) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 150

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Trinh, M. N., Brown, M. S., Goldstein, J. L., Han, J., Vale, G., McDonald, J. G., Seemann, J., Mendell, J. T., & Lu, F. (2020) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismLipid Membrane Structure and Behavior

Cited by 129

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice

Hofmann, S. L., Russell, D. W., Brown, M. S., Goldstein, J. L., & Hammer, R. E. (1988) · Science

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 117

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.

Engelking, L. J., Evers, B. M., Richardson, J. A., Goldstein, J. L., Brown, M. S., & Liang, G. (2006) · Journal of Clinical Investigation

Cleft Lip and Palate ResearchCholesterol and Lipid Metabolism

Cited by 82

HDL miR -ed Down by SREBP Introns

Brown, M. S., Ye, J., & Goldstein, J. L. (2010) · Science

Cholesterol and Lipid MetabolismMicroRNA in disease regulation

Cited by 43