Koob, George F.

Addiction as a stress surfeit disorder

Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., et al. (2014) · Neuropharmacology

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 483

Neurobiology of opioid addiction: Opponent process, hyperkatifeia, and negative reinforcement

Koob, G. F. (2020) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 477

Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats

Roberts, D. C. S., & Koob, G. F. (1982) · Pharmacology Biochemistry and Behavior

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 448

The dark side of emotion: the addiction perspective

Koob, G. F. (2015) · European Journal of Pharmacology

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 433

Modulation of social memory in male rats by neurohypophyseal peptides

Dantzer, R., Bluthe, R. M., Koob, G. F., & Le Moal, M. (1987) · Psychopharmacology

Neuroendocrine regulation and behaviorMemory and Neural Mechanisms

Cited by 423

The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse

Wee, S., & Koob, G. F. (2010) · Psychopharmacology

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 398

The neurobiology of addiction: a neuroadaptational view relevant for diagnosis

Koob, G. F. (2006) · Addiction

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 397

Addiction is a Reward Deficit and Stress Surfeit Disorder

Koob, G. F. (2013) · Frontiers in Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 397

Addictions neuroclinical assessment: a neuroscience-based framework for addictive disorders

Kwako, L. E., Momenan, R., Litten, R. Z., Koob, G. F., & Goldman, D. (2016) · Biological Psychiatry

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 395

Pharmacological evidence for a motivational role of κ-opioid systems in ethanol dependence

Walker, B. M., & Koob, G. F. (2008) · Neuropsychopharmacology

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 392

Neurobiological evidence for hedonic allostasis associated with escalating cocaine use

Ahmed, S. H., Kenny, P. J., Koob, G. F., & Markou, A. (2002) · Nature Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 389

Brain stress systems in the amygdala and addiction

Koob, G. F. (2009) · Brain Research

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 388

Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor

Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · Alcoholism: Clinical and Experimental Research

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 387

Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats

Funk, C. K., O'Dell, L. E., Crawford, E. F., & Koob, G. F. (2006) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 381

Functional interaction between opioid and cannabinoid receptors in drug self-administration.

Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., et al. (2001) · The Journal of Neuroscience

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 378

Corticotropin-Releasing Factor in Brain: A Role in Activation, Arousal, and Affect Regulation

Heinrichs, S. C., & Koob, G. F. (2004) · The Journal of Pharmacology and Experimental Therapeutics

Neuropeptides and Animal PhysiologyStress Responses and Cortisol

Cited by 353

Alcohol dependence as a chronic pain disorder

Egli, M., Koob, G. F., & Edwards, S. (2012) · Neuroscience & Biobehavioral Reviews

Pain Mechanisms and TreatmentsSubstance Abuse Treatment and Outcomes

Cited by 347

Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats

Roberts, A. J., Cole, M., & Koob, G. F. (1996) · Alcoholism: Clinical and Experimental Research

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 340

Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

Koob, G. F. (2021) · Pharmacological Reviews

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 337

Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence

Roberto, M., Cruz, M. T., Gilpin, N. W., Sabino, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., et al. (2010) · Biological Psychiatry

Neuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

Cited by 336

Heterogeneity of Alcohol Use Disorder: Understanding Mechanisms to Advance Personalized Treatment

Litten, R. Z., Ryan, M. L., Falk, D. E., Reilly, M., Fertig, J. B., & Koob, G. F. (2015) · Alcoholism: Clinical and Experimental Research

Substance Abuse Treatment and OutcomesAlcohol Consumption and Health Effects

Cited by 330

Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats

Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., et al. (2012) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 319

Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration

Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F. (1992) · Brain Research

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 318

Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal

Stinus, L., Le Moal, M., & Koob, G. F. (1990) · Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 317