Koob, George F.

Neurobiology of dysregulated motivational systems in drug addiction

Edwards, S., & Koob, G. F. (2010) · Future Neurology

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 157

Development of pharmacotherapies for drug addiction: a Rosetta stone approach

Koob, G. F., Kenneth Lloyd, G., & Mason, B. J. (2009) · Nature Reviews Drug Discovery

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 154

Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction

O’Dell, L. E., Bruijnzeel, A. W., Smith, R. T., Parsons, L. H., Merves, M. L., Goldberger, B. A., Richardson, H. N., Koob, G. F., & Markou, A. (2006) · Psychopharmacology

Smoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Cited by 153

CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats

Navarro, M., Chowen, J., Carrera, M. R. A., del Arco, I., Villanúa, M. A., Martin, Y., Roberts, A. J., Koob, G. F., & de Fonseca, F. R. (1998) · NeuroReport

Cannabis and Cannabinoid ResearchNeuropeptides and Animal Physiology

Cited by 152

The functional output of the mesolimbic dopamine system

KOOB, G. F., & SWERDLOW, N. R. (1988) · Annals of the New York Academy of Sciences

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 149

Dynorphin, dysphoria and dependence: the stress of addiction

Chavkin, C., & Koob, G. F. (2016) · Neuropsychopharmacology

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 149

Anti-Stress Action of a Corticotropin-Releasing Factor Antagonist on Behavioral Reactivity to Stressors of Varying Type and Intensity

Heinrichs, S. C., Menzaghi, F., Pich, E. M., Baldwin, H. A., Rassnick, S., Britton, K. T., & Koob, G. F. (1994) · Neuropsychopharmacology

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 143

Biomarkers in Substance Use Disorders

Volkow, N. D., Koob, G., & Baler, R. (2015) · ACS Chemical Neuroscience

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 141

Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats

Stinus, L., Cador, M., Zorrilla, E. P., & Koob, G. F. (2005) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 139

Neurofunctional domains derived from deep behavioral phenotyping in alcohol use disorder

Kwako, L. E., Schwandt, M. L., Ramchandani, V. A., Diazgranados, N., Koob, G. F., Volkow, N. D., Blanco, C., & Goldman, D. (2019) · American Journal of Psychiatry

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 138

Increased Anxiety‐Like Behavior and Ethanol Self‐Administration in Dependent Rats: Reversal via Corticotropin‐Releasing Factor‐2 Receptor Activation

Valdez, G. R., Sabino, V., & Koob, G. F. (2004) · Alcoholism: Clinical and Experimental Research

Neuropeptides and Animal PhysiologyStress Responses and Cortisol

Cited by 131

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats

de Guglielmo, G., Kallupi, M., Pomrenze, M. B., Crawford, E., Simpson, S., Schweitzer, P., Koob, G. F., Messing, R. O., & George, O. (2019) · Nature Communications

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 127

Cellular and behavioral interactions of gabapentin with alcohol dependence

Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., & Koob, G. F. (2008) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 126

Pathological overeating: emerging evidence for a compulsivity construct

Moore, C. F., Sabino, V., Koob, G. F., & Cottone, P. (2017) · Neuropsychopharmacology

Eating Disorders and BehaviorsNutrition, Health and Food Behavior

Cited by 126

Existing and future drugs for the treatment of the dark side of addiction

Koob, G. F., & Mason, B. J. (2016) · Annual Review of Pharmacology and Toxicology

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 121

Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake

Schlosburg, J. E., Whitfield, T. W., Park, P. E., Crawford, E. F., George, O., Vendruscolo, L. F., & Koob, G. F. (2013) · The Journal of Neuroscience

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 119

Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence

Gilpin, N. W., Misra, K., Herman, M. A., Cruz, M. T., Koob, G. F., & Roberto, M. (2011) · Biological Psychiatry

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 116

Hedonic homeostatic dysregulation as a driver of drug-seeking behavior

Koob, G. F. (2008) · Drug Discovery Today Disease Models

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 114

Preaddiction—A Missing Concept for Treating Substance Use Disorders

McLellan, A. T., Koob, G. F., & Volkow, N. D. (2022) · JAMA Psychiatry

Substance Abuse Treatment and OutcomesOpioid Use Disorder Treatment

Cited by 112

Remembering the forgotten non-communicable diseases

Lopez, A. D., Williams, T. N., Levin, A., Tonelli, M., Singh, J. A., Burney, P. G., Rehm, J., Volkow, N. D., Koob, G., & Ferri, C. P. (2014) · BMC Medicine

Global Health and EpidemiologyHealthcare Systems and Public Health

Cited by 108

Recruitment of a neuronal ensemble in the central nucleus of the amygdala is required for alcohol dependence

de Guglielmo, G., Crawford, E., Kim, S., Vendruscolo, L. F., Hope, B. T., Brennan, M., Cole, M., Koob, G. F., & George, O. (2016) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 106

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., et al. (2019) · PLOS Biology

Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

Cited by 104

Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats

Gilpin, N. W., & Koob, G. F. (2010) · Psychopharmacology

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 99

Unlimited Access to Heroin Self-Administration: Independent Motivational Markers of Opiate Dependence

Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P., & Koob, G. F. (2006) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorOpioid Use Disorder Treatment

Cited by 97