Kipnis, Jonathan

Multifaceted interactions between adaptive immunity and the central nervous system

Kipnis, J. (2016) · Science

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 376

Microbiota alteration is associated with the development of stress-induced despair behavior

Marin, I. A., Goertz, J. E., Ren, T., Rich, S. S., Onengut-Gumuscu, S., Farber, E., Wu, M., Overall, C. C., Kipnis, J., & Gaultier, A. (2017) · Scientific Reports

Gut microbiota and healthTryptophan and brain disorders

Cited by 369

Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration

Silvin, A., Uderhardt, S., Piot, C., Da Mesquita, S., Yang, K., Geirsdottir, L., Mulder, K., Eyal, D., Liu, Z., Bridlance, C., et al. (2022) · Immunity

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 368

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

Gadani, S. P., Walsh, J. T., Smirnov, I., Zheng, J., & Kipnis, J. (2015) · Neuron

Neuroinflammation and Neurodegeneration MechanismsIL-33, ST2, and ILC Pathways

Cited by 359

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.

Bolte, A. C., Dutta, A. B., Hurt, M. E., Smirnov, I., Kovacs, M. A., McKee, C. A., Ennerfelt, H. E., Shapiro, D., Nguyen, B. H., Frost, E. L., et al. (2020) · Nature Communications

Traumatic Brain Injury and Neurovascular DisturbancesCerebrospinal fluid and hydrocephalus

Cited by 357

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

Alves de Lima, K., Rustenhoven, J., & Kipnis, J. (2020) · Annual Review of Immunology

Neuroinflammation and Neurodegeneration MechanismsBacterial Infections and Vaccines

Cited by 348

Dealing with danger in the CNS: the response of the immune system to injury

Gadani, S. P., Walsh, J. T., Lukens, J. R., & Kipnis, J. (2015) · Neuron

Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 342

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Drieu, A., Du, S., Storck, S. E., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., et al. (2022) · Nature

Cerebrospinal fluid and hydrocephalusNeuroinflammation and Neurodegeneration Mechanisms

Cited by 325

Immune cells and CNS physiology: Microglia and beyond

Norris, G. T., & Kipnis, J. (2019) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 274

Identification of direct connections between the dura and the brain

Smyth, L. C. D., Xu, D., Okar, S. V., Dykstra, T., Rustenhoven, J., Papadopoulos, Z., Bhasiin, K., Kim, M. W., Drieu, A., Mamuladze, T., et al. (2024) · Nature

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 264

ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

Seo, D.-O., O’Donnell, D., Jain, N., Ulrich, J. D., Herz, J., Li, Y., Lemieux, M., Cheng, J., Hu, H., Serrano, J. R., et al. (2023) · Science

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 254

Brain borders at the central stage of neuroimmunology

Rustenhoven, J., & Kipnis, J. (2022) · Nature

Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Cited by 253

Pro-cognitive properties of T cells

Kipnis, J., Gadani, S., & Derecki, N. C. (2012) · Nature Reviews Immunology

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 246

Adaptive immunity affects learning behavior in mice

Brynskikh, A., Warren, T., Zhu, J., & Kipnis, J. (2008) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 221

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., et al. (2018) · Immunity

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 220

Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance

Jiang-Xie, L.-F., Drieu, A., Bhasiin, K., Quintero, D., Smirnov, I., & Kipnis, J. (2024) · Nature

Cerebrospinal fluid and hydrocephalusNeural dynamics and brain function

Cited by 220

How and why do T cells and their derived cytokines affect the injured and healthy brain?

Filiano, A. J., Gadani, S. P., & Kipnis, J. (2017) · Nature Reviews Neuroscience

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 199

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

Cronk, J. C., Derecki, N. C., Ji, E., Xu, Y., Lampano, A. E., Smirnov, I., Baker, W., Norris, G. T., Marin, I., Coddington, N., et al. (2015) · Immunity

Genetics and Neurodevelopmental DisordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 199

Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4+CD25+ cells

Cohen, H., Ziv, Y., Cardon, M., Kaplan, Z., Matar, M. A., Gidron, Y., Schwartz, M., & Kipnis, J. (2006) · Journal of Neurobiology

Stress Responses and CortisolT-cell and B-cell Immunology

Cited by 173

Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology

Da Mesquita, S., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W., & Kipnis, J. (2021) · Science Advances

Neuroinflammation and Neurodegeneration MechanismsCerebrospinal fluid and hydrocephalus

Cited by 172

Learning and memory … and the immune system

Marin, I., & Kipnis, J. (2013) · Learning & Memory

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 166

Understanding the Role of T Cells in CNS Homeostasis

Ellwardt, E., Walsh, J. T., Kipnis, J., & Zipp, F. (2016) · Trends in Immunology

Neuroinflammation and Neurodegeneration MechanismsT-cell and B-cell Immunology

Cited by 156

Skull bone marrow channels as immune gateways to the central nervous system

Mazzitelli, J. A., Pulous, F. E., Smyth, L. C. D., Kaya, Z., Rustenhoven, J., Moskowitz, M. A., Kipnis, J., & Nahrendorf, M. (2023) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Cited by 116

Dynamics of the meningeal CD4+ T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice

Radjavi, A., Smirnov, I., Derecki, N., & Kipnis, J. (2014) · Molecular Psychiatry

T-cell and B-cell ImmunologyNeuroinflammation and Neurodegeneration Mechanisms

Cited by 112