Simell, Olli

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children

Ziegler, A. G., Rewers, M., Simell, O., Simell, T., Lempainen, J., Steck, A., Winkler, C., Ilonen, J., Veijola, R., Knip, M., et al. (2013) · JAMA

Diabetes and associated disordersDiabetes Management and Research

Cited by 1,312

Toward defining the autoimmune microbiome for type 1 diabetes

Giongo, A., Gano, K. A., Crabb, D. B., Mukherjee, N., Novelo, L. L., Casella, G., Drew, J. C., Ilonen, J., Knip, M., Hyöty, H., et al. (2011) · The ISME Journal

Gut microbiota and healthDiabetes and associated disorders

Cited by 806

Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes

Brown, C. T., Davis-Richardson, A. G., Giongo, A., Gano, K. A., Crabb, D. B., Mukherjee, N., Casella, G., Drew, J. C., Ilonen, J., Knip, M., et al. (2011) · PLoS ONE

Gut microbiota and healthDiabetes and associated disorders

Cited by 778

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

Orešič, M., Simell, S., Sysi-Aho, M., Näntö-Salonen, K., Seppänen-Laakso, T., Parikka, V., Katajamaa, M., Hekkala, A., Mattila, I., Keskinen, P., et al. (2008) · The Journal of Experimental Medicine

Diabetes and associated disordersMetabolomics and Mass Spectrometry Studies

Cited by 449

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study

the TEDDY Study Group, Krischer, J. P., Lynch, K. F., Schatz, D. A., Ilonen, J., Lernmark, Å., Hagopian, W. A., Rewers, M. J., She, J.-X., Simell, O. G., et al. (2015) · Diabetologia

Diabetes and associated disordersDiabetes Management and Research

Cited by 444

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

The Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC), Horikoshi, M., Early Growth Genetics (EGG) Consortium, Yaghootkar, H., Mook-Kanamori, D. O., Sovio, U., Taal, H. R., Hennig, B. J., Bradfield, J. P., St Pourcain, B., et al. (2013) · Nature Genetics

Birth, Development, and HealthGenetic Associations and Epidemiology

Cited by 309

Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes–indication of an increased environmental pressure?

the FinnDiane Study Group, Hermann, R., Knip, M., Veijola, R., Simell, O., Laine, A.-P., Åkerblom, H. K., Groop, P.-H., Forsblom, C., Pettersson-Fernholm, K., et al. (2003) · Diabetologia

Diabetes and associated disordersGenetic Associations and Epidemiology

Cited by 245

Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk

Parikka, V., Näntö-Salonen, K., Saarinen, M., Simell, T., Ilonen, J., Hyöty, H., Veijola, R., Knip, M., & Simell, O. (2012) · Diabetologia

Diabetes and associated disordersDiabetes Management and Research

Cited by 235

Predictors of progression from the appearance of islet autoantibodies to early childhood diabetes: the environmental determinants of diabetes in the young (TEDDY)

Steck, A. K., Vehik, K., Bonifacio, E., Lernmark, A., Ziegler, A.-G., Hagopian, W. A., She, J., Simell, O., Akolkar, B., Krischer, J., et al. (2015) · Diabetes Care

Diabetes and associated disordersDiabetes Management and Research

Cited by 185

Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes

Vaarala, O., Knip, M., Paronen, J., Hämäläinen, A. M., Muona, P., Väätäinen, M., Ilonen, J., Simell, O., & Akerblom, H. K. (1999) · Diabetes

Diabetes and associated disordersInfant Nutrition and Health

Cited by 182

Timing of infant feeding in relation to childhood asthma and allergic diseases

Nwaru, B. I., Takkinen, H.-M., Niemelä, O., Kaila, M., Erkkola, M., Ahonen, S., Haapala, A.-M., Kenward, M. G., Pekkanen, J., Lahesmaa, R., et al. (2013) · Journal of Allergy and Clinical Immunology

Asthma and respiratory diseasesFood Allergy and Anaphylaxis Research

Cited by 151

A combined risk score enhances prediction of type 1 diabetes among susceptible children

Ferrat, L. A., Vehik, K., Sharp, S. A., Lernmark, Å., Rewers, M. J., She, J.-X., Ziegler, A.-G., Toppari, J., Akolkar, B., Krischer, J. P., et al. (2020) · Nature Medicine

Diabetes and associated disordersDiabetes Management and Research

Cited by 148

Natural History of β-Cell Autoimmunity in Young Children with Increased Genetic Susceptibility to Type 1 Diabetes Recruited from the General Population

Kimpimäki, T., Kulmala, P., Savola, K., Kupila, A., Korhonen, S., Simell, T., Ilonen, J., Simell, O., & Knip, M. (2002) · The Journal of Clinical Endocrinology & Metabolism

Diabetes and associated disordersDiabetes Management and Research

Cited by 146

TEDDY–The Environmental Determinants of Diabetes in the Young: An Observational Clinical Trial

HAGOPIAN, W. A., LERNMARK, Å., REWERS, M. J., SIMELL, O. G., SHE, J., ZIEGLER, A. G., KRISCHER, J. P., & AKOLKAR, B. (2006) · Annals of the New York Academy of Sciences

Diabetes and associated disordersDiabetes Management and Research

Cited by 125

Gyrate Atrophy of the Choroid and Retina

Vannas-Sulonen, K., Sipilä, I., Vannas, A., Simell, O., & Rapola, J. (1985) · Ophthalmology

Metabolism and Genetic DisordersRetinal Development and Disorders

Cited by 124

Dynamics of Diabetes-Associated Autoantibodies in Young Children with Human Leukocyte Antigen-Conferred Risk of Type 1 Diabetes Recruited from the General Population

Kukko, M., Kimpimäki, T., Korhonen, S., Kupila, A., Simell, S., Veijola, R., Simell, T., Ilonen, J., Simell, O., & Knip, M. (2005) · The Journal of Clinical Endocrinology & Metabolism

Diabetes and associated disordersDiabetes Management and Research

Cited by 116

Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease: Intense follow-up enables early detection of type 1 diabetes

Elding Larsson, H., Vehik, K., Gesualdo, P., Akolkar, B., Hagopian, W., Krischer, J., Lernmark, Å., Rewers, M., Simell, O., She, J.-X., et al. (2014) · Pediatric Diabetes

Diabetes and associated disordersDiabetes Management and Research

Cited by 103

Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study

Vehik, K., Lynch, K. F., Schatz, D. A., Akolkar, B., Hagopian, W., Rewers, M., She, J.-X., Simell, O., Toppari, J., Ziegler, A.-G., et al. (2016) · Diabetes Care

Diabetes and associated disordersDiabetes Management and Research

Cited by 103

Intranasally administered insulin intended for prevention of type 1 diabetes—a safety study in healthy adults

Kupila, A., Sipilä, J., Keskinen, P., Simell, T., Knip, M., Pulkki, K., & Simell, O. (2003) · Diabetes/Metabolism Research and Reviews

Diabetes and associated disordersDiabetes Management and Research

Cited by 64

Human parechoviruses are frequently detected in stool of healthy Finnish children

Kolehmainen, P., Oikarinen, S., Koskiniemi, M., Simell, O., Ilonen, J., Knip, M., Hyöty, H., & Tauriainen, S. (2012) · Journal of Clinical Virology

Viral Infections and Immunology ResearchViral gastroenteritis research and epidemiology

Cited by 62

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children

Jacobsen, L. M., Larsson, H. E., Tamura, R. N., Vehik, K., Clasen, J., Sosenko, J., Hagopian, W. A., She, J., Steck, A. K., Rewers, M., et al. (2019) · Pediatric Diabetes

Diabetes and associated disordersDiabetes Management and Research

Cited by 48

Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility

Siljander, H., Härkönen, T., Hermann, R., Simell, S., Hekkala, A., Salonsaari, R., Simell, T., Simell, O., Ilonen, J., Veijola, R., et al. (2009) · Diabetes/Metabolism Research and Reviews

Diabetes and associated disordersDiabetes Management and Research

Cited by 30

Maternal intake of fatty acids and their food sources during lactation and the risk of preclinical and clinical type 1 diabetes in the offspring

Niinistö, S., Takkinen, H.-M., Uusitalo, L., Rautanen, J., Vainio, N., Ahonen, S., Nevalainen, J., Kenward, M. G., Lumia, M., Simell, O., et al. (2015) · Acta Diabetologica

Diabetes and associated disordersNutritional Studies and Diet

Cited by 16