Most cited biochemistry, genetics and molecular biology papers
- Verified
Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
Si-Tayeb, K., Noto, F. K., Nagaoka, M., Li, J., Battle, M. A., Duris, C., North, P. E., Dalton, S., & Duncan, S. A. (2010) · Hepatology
Pluripotent Stem Cells ResearchMesenchymal stem cell research
Cited by 1,282
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Genomic imprinting in mammalian development: a parental tug-of-war
Moore, T. (1991) · Trends in Genetics
Genetic Syndromes and ImprintingChromosomal and Genetic Variations
Cited by 1,281
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Turning a hobby into a job: How duplicated genes find new functions
Conant, G. C., & Wolfe, K. H. (2008) · Nature Reviews Genetics
Chromosomal and Genetic VariationsEvolution and Genetic Dynamics
Cited by 1,281
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Colonic bacterial composition in Parkinson's disease
Keshavarzian, A., Green, S. J., Engen, P. A., Voigt, R. M., Naqib, A., Forsyth, C. B., Mutlu, E., & Shannon, K. M. (2015) · Movement Disorders
Gut microbiota and healthParkinson's Disease Mechanisms and Treatments
Cited by 1,281
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Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
Tsien, J. Z., Chen, D. F., Gerber, D., Tom, C., Mercer, E. H., Anderson, D. J., Mayford, M., Kandel, E. R., & Tonegawa, S. (1996) · Cell
Animal Genetics and ReproductionCRISPR and Genetic Engineering
Cited by 1,280
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Cell2location maps fine-grained cell types in spatial transcriptomics
Kleshchevnikov, V., Shmatko, A., Dann, E., Aivazidis, A., King, H. W., Li, T., Elmentaite, R., Lomakin, A., Kedlian, V., Gayoso, A., et al. (2022) · Nature Biotechnology
Single-cell and spatial transcriptomicsGene expression and cancer classification
Cited by 1,279
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Telomere elongation in immortal human cells without detectable telomerase activity
Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S., & Reddel, R. R. (1995) · The EMBO Journal
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms
Cited by 1,279
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c-Myc Regulates Transcriptional Pause Release
Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell
Genomics and Chromatin DynamicsChromatin Remodeling and Cancer
Cited by 1,279
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The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
Elbaum-Garfinkle, S., Kim, Y., Szczepaniak, K., Chen, C. C.-H., Eckmann, C. R., Myong, S., & Brangwynne, C. P. (2015) · Proceedings of the National Academy of Sciences
RNA Research and SplicingRNA and protein synthesis mechanisms
Cited by 1,278
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Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S., & Green, D. R. (2011) · Nature
Cell death mechanisms and regulationNF-κB Signaling Pathways
Cited by 1,278
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Prader-Willi Syndrome: Consensus Diagnostic Criteria
Holm, V. A., Cassidy, S. B., Butler, M. G., Hanchett, J. M., Greenswag, L. R., Whitman, B. Y., & Greenberg, F. (1993) · Pediatrics
Genetic Syndromes and ImprintingGenomic variations and chromosomal abnormalities
Cited by 1,278
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Rare and common variants: twenty arguments
Gibson, G. (2012) · Nature Reviews Genetics
Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock
Cited by 1,278
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The conserved domain database in 2023
Wang, J., Chitsaz, F., Derbyshire, M. K., Gonzales, N. R., Gwadz, M., Lu, S., Marchler, G. H., Song, J. S., Thanki, N., Yamashita, R. A., et al. (2023) · Nucleic Acids Research
Genomics and Phylogenetic StudiesProtein Structure and Dynamics
Cited by 1,277
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Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia
Cavazzana-Calvo, M., Payen, E., Negre, O., Wang, G., Hehir, K., Fusil, F., Down, J., Denaro, M., Brady, T., Westerman, K., et al. (2010) · Nature
Virus-based gene therapy researchHemoglobinopathies and Related Disorders
Cited by 1,276
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A genome-wide search for human type 1 diabetes susceptibility genes
Davies, J. L., Kawaguchi, Y., Bennett, S. T., Copeman, J. B., Cordell, H. J., Pritchard, L. E., Reed, P. W., Gough, S. C. L., Jenkins, S. C., Palmer, S. M., et al. (1994) · Nature
Diabetes and associated disordersGenetic Associations and Epidemiology
Cited by 1,276
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The Molecular Basis of Muscular Dystrophy in the mdx Mouse: a Point Mutation
Sicinski, P., Geng, Y., Ryder-Cook, A. S., Barnard, E. A., Darlison, M. G., & Barnard, P. J. (1989) · Science
Muscle Physiology and DisordersCardiomyopathy and Myosin Studies
Cited by 1,276
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A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
Hung, R. J., McKay, J. D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., et al. (2008) · Nature
Genetic Associations and EpidemiologySmoking Behavior and Cessation
Cited by 1,275
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Markov models of molecular kinetics: Generation and validation
Prinz, J.-H., Wu, H., Sarich, M., Keller, B., Senne, M., Held, M., Chodera, J. D., Schütte, C., & Noé, F. (2011) · The Journal of Chemical Physics
Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions
Cited by 1,275
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An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
Kornmann, B., Currie, E., Collins, S. R., Schuldiner, M., Nunnari, J., Weissman, J. S., & Walter, P. (2009) · Science
Mitochondrial Function and PathologyCellular transport and secretion
Cited by 1,275
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Low counts of Faecalibacterium prausnitzii in colitis microbiota
Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G., Marteau, P., & Doré, J. (2009) · Inflammatory Bowel Diseases
Gut microbiota and healthInflammatory Bowel Disease
Cited by 1,275
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Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms
Cited by 1,275
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Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
Chen, R. Z., Akbarian, S., Tudor, M., & Jaenisch, R. (2001) · Nature Genetics
Genetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation
Cited by 1,275
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Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
Yang, L., Li, P., Fu, S., Calay, E. S., & Hotamisligil, G. S. (2010) · Cell Metabolism
Autophagy in Disease and TherapyMetabolism, Diabetes, and Cancer
Cited by 1,274
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Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer
Schmid, P., Cortes, J., Dent, R., Pusztai, L., McArthur, H., Kümmel, S., Bergh, J., Denkert, C., Park, Y. H., Hui, R., et al. (2022) · New England Journal of Medicine
Breast Cancer Treatment StudiesCancer Immunotherapy and Biomarkers
Cited by 1,274
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