Check biochemistry, genetics and molecular biology papers: citations, claims and retractions

The updated landscape of tumor microenvironment and drug repurposing

Jin, M.-Z., & Jin, W.-L. (2020) · Signal Transduction and Targeted Therapy

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 1,262

mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

Holz, M. K., Ballif, B. A., Gygi, S. P., & Blenis, J. (2005) · Cell

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 1,262

Diet, gut microbiota and immune responses

Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology

Gut microbiota and healthAsthma and respiratory diseases

Cited by 1,261

Homeostatic Immunity and the Microbiota

Belkaid, Y., & Harrison, O. J. (2017) · Immunity

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 1,261

Universally Sloppy Parameter Sensitivities in Systems Biology Models

Gutenkunst, R. N., Waterfall, J. J., Casey, F. P., Brown, K. S., Myers, C. R., & Sethna, J. P. (2007) · PLoS Computational Biology

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 1,261

DNA methylation age of blood predicts all-cause mortality in later life

Marioni, R. E., Shah, S., McRae, A. F., Chen, B. H., Colicino, E., Harris, S. E., Gibson, J., Henders, A. K., Redmond, P., Cox, S. R., et al. (2015) · Genome Biology

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 1,261

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Cantley, W. L., Dorkin, J. R., et al. (2010) · Molecular Therapy

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 1,261

Generation of reactive oxygen species by the mitochondrial electron transport chain

Liu, Y., Fiskum, G., & Schubert, D. (2002) · Journal of Neurochemistry

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 1,260

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., et al. (2006) · Nature Genetics

Genetic and phenotypic traits in livestockMuscle Physiology and Disorders

Cited by 1,260

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

Rayner, K. J., Suárez, Y., Dávalos, A., Parathath, S., Fitzgerald, M. L., Tamehiro, N., Fisher, E. A., Moore, K. J., & Fernández-Hernando, C. (2010) · Science

Cholesterol and Lipid MetabolismMicroRNA in disease regulation

Cited by 1,260

The microRNAs of Caenorhabditis elegans

Lim, L. P., Lau, N. C., Weinstein, E. G., Abdelhakim, A., Yekta, S., Rhoades, M. W., Burge, C. B., & Bartel, D. P. (2003) · Genes & Development

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 1,259

Lysosomal acidification mechanisms

Mindell, J. A. (2012) · Annual Review of Physiology

ATP Synthase and ATPases ResearchCellular transport and secretion

Cited by 1,258

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

Sriram, K., & Insel, P. A. (2018) · Molecular Pharmacology

Receptor Mechanisms and SignalingComputational Drug Discovery Methods

Cited by 1,258

When cilia go bad: cilia defects and ciliopathies

Fliegauf, M., Benzing, T., & Omran, H. (2007) · Nature Reviews Molecular Cell Biology

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 1,257

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P. K., Kivioja, T., Dave, K., Zhong, F., et al. (2017) · Science

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 1,257

BRCAness revisited

Lord, C. J., & Ashworth, A. (2016) · Nature Reviews Cancer

BRCA gene mutations in cancerPARP inhibition in cancer therapy

Cited by 1,257

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

Kagan, V. E., Tyurin, V. A., Jiang, J., Tyurina, Y. Y., Ritov, V. B., Amoscato, A. A., Osipov, A. N., Belikova, N. A., Kapralov, A. A., Kini, V., et al. (2005) · Nature Chemical Biology

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 1,256

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C., & Semenza, G. L. (2001) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 1,256

Understanding mechanisms underlying human gene expression variation with RNA sequencing

Pickrell, J. K., Marioni, J. C., Pai, A. A., Degner, J. F., Engelhardt, B. E., Nkadori, E., Veyrieras, J.-B., Stephens, M., Gilad, Y., & Pritchard, J. K. (2010) · Nature

Genetic Associations and EpidemiologyRNA Research and Splicing

Cited by 1,256

Museum of spatial transcriptomics

Moses, L., & Pachter, L. (2022) · Nature Methods

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 1,255

The antioxidant properties of serum albumin

Roche, M., Rondeau, P., Singh, N. R., Tarnus, E., & Bourdon, E. (2008) · FEBS Letters

Protein Interaction Studies and Fluorescence AnalysisAntioxidant Activity and Oxidative Stress

Cited by 1,255

Defining the human microbiome

Ursell, L. K., Metcalf, J. L., Parfrey, L. W., & Knight, R. (2012) · Nutrition Reviews

Gut microbiota and healthMicrobial Community Ecology and Physiology

Cited by 1,255

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 1,255

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,255