Check biochemistry, genetics and molecular biology papers: citations, claims and retractions

The ensemble nature of allostery

Motlagh, H. N., Wrabl, J. O., Li, J., & Hilser, V. J. (2014) · Nature

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 1,247

Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution

Cramer, P., Bushnell, D. A., & Kornberg, R. D. (2001) · Science

Genomics and Chromatin DynamicsEnzyme Structure and Function

Cited by 1,247

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium, Almanzar, N., Antony, J., Baghel, A. S., Bakerman, I., Bansal, I., Barres, B. A., Beachy, P. A., Berdnik, D., Bilen, B., et al. (2020) · Nature

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 1,247

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

Orrù, V., Steri, M., Sidore, C., Marongiu, M., Serra, V., Olla, S., Sole, G., Lai, S., Dei, M., Mulas, A., et al. (2020) · Nature Genetics

Genetic Associations and EpidemiologyMultiple Sclerosis Research Studies

Cited by 1,246

Hybrid origins of plant species

Rieseberg, L. H. (1997) · Annual Review of Ecology and Systematics

Chromosomal and Genetic VariationsPlant Diversity and Evolution

Cited by 1,246

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

Chemnitz, J. M., Parry, R. V., Nichols, K. E., June, C. H., & Riley, J. L. (2004) · The Journal of Immunology

Protein Tyrosine PhosphatasesT-cell and B-cell Immunology

Cited by 1,246

Twenty-Five Years of Quantitative PCR for Gene Expression Analysis

VanGuilder, H. D., Vrana, K. E., & Freeman, W. M. (2008) · BioTechniques

Molecular Biology Techniques and ApplicationsGene expression and cancer classification

Cited by 1,246

Transvascular delivery of small interfering RNA to the central nervous system

Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature

RNA Interference and Gene DeliveryBarrier Structure and Function Studies

Cited by 1,246

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

Yu, T., Robotham, J. L., & Yoon, Y. (2006) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,246

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

Carreau, A., Hafny‐Rahbi, B. E., Matejuk, A., Grillon, C., & Kieda, C. (2011) · Journal of Cellular and Molecular Medicine

Cancer, Hypoxia, and MetabolismBiomedical and Chemical Research

Cited by 1,246

Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging

Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 1,245

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 1,245

Understanding MAPK Signaling Pathways in Apoptosis

Yue, J., & López, J. M. (2020) · International Journal of Molecular Sciences

Cell death mechanisms and regulationProtein Kinase Regulation and GTPase Signaling

Cited by 1,245

Regulation of Small GTPases by GEFs, GAPs, and GDIs

Cherfils, J., & Zeghouf, M. (2013) · Physiological Reviews

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 1,245

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 1,245

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

Fenech, M., Kirsch-Volders, M., Natarajan, A. T., Surralles, J., Crott, J. W., Parry, J., Norppa, H., Eastmond, D. A., Tucker, J. D., & Thomas, P. (2011) · Mutagenesis

Carcinogens and Genotoxicity AssessmentDNA Repair Mechanisms

Cited by 1,244

Methods and applications for single-cell and spatial multi-omics

Vandereyken, K., Sifrim, A., Thienpont, B., & Voet, T. (2023) · Nature Reviews Genetics

Single-cell and spatial transcriptomicsBioinformatics and Genomic Networks

Cited by 1,244

mRNAs, proteins and the emerging principles of gene expression control

Buccitelli, C., & Selbach, M. (2020) · Nature Reviews Genetics

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 1,243

Genome-scale CRISPR-Cas9 Knockout and Transcriptional Activation Screening

Joung, J., Konermann, S., Gootenberg, J. S., Abudayyeh, O. O., Platt, R. J., Brigham, M. D., Sanjana, N. E., & Zhang, F. (2017) · Nature Protocols

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 1,243

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

Levine, A. J., & Puzio-Kuter, A. M. (2010) · Science

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,243

Persistent bacterial infections and persister cells

Fisher, R. A., Gollan, B., & Helaine, S. (2017) · Nature Reviews Microbiology

Bacterial Genetics and BiotechnologyBacterial biofilms and quorum sensing

Cited by 1,243

Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

Gibson, D. G., Benders, G. A., Andrews-Pfannkoch, C., Denisova, E. A., Baden-Tillson, H., Zaveri, J., Stockwell, T. B., Brownley, A., Thomas, D. W., Algire, M. A., et al. (2008) · Science

CRISPR and Genetic EngineeringMicrobial infections and disease research

Cited by 1,243

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 1,243

Mitochondria and neuronal survival

Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 1,243