Most cited biochemistry, genetics and molecular biology papers
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Liquid biopsy enters the clinic — implementation issues and future challenges
Ignatiadis, M., Sledge, G. W., & Jeffrey, S. S. (2021) · Nature Reviews Clinical Oncology
Cancer Genomics and DiagnosticsPrenatal Screening and Diagnostics
Cited by 1,191
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Searching molecular structure databases with tandem mass spectra using CSI:FingerID
Dührkop, K., Shen, H., Meusel, M., Rousu, J., & Böcker, S. (2015) · Proceedings of the National Academy of Sciences
Metabolomics and Mass Spectrometry StudiesMass Spectrometry Techniques and Applications
Cited by 1,190
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Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
Shalek, A. K., Satija, R., Adiconis, X., Gertner, R. S., Gaublomme, J. T., Raychowdhury, R., Schwartz, S., Yosef, N., Malboeuf, C., Lu, D., et al. (2013) · Nature
Single-cell and spatial transcriptomicsRNA Research and Splicing
Cited by 1,190
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Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors
Tong, R. T., Boucher, Y., Kozin, S. V., Winkler, F., Hicklin, D. J., & Jain, R. K. (2004) · Cancer Research
Angiogenesis and VEGF in CancerLymphatic System and Diseases
Cited by 1,189
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DNA damage and the balance between survival and death in cancer biology
Roos, W. P., Thomas, A. D., & Kaina, B. (2016) · Nature Reviews Cancer
DNA Repair MechanismsCell death mechanisms and regulation
Cited by 1,189
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An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes
Herold, K. C., Bundy, B. N., Long, S. A., Bluestone, J. A., DiMeglio, L. A., Dufort, M. J., Gitelman, S. E., Gottlieb, P. A., Krischer, J. P., Linsley, P. S., et al. (2019) · New England Journal of Medicine
Diabetes and associated disordersT-cell and B-cell Immunology
Cited by 1,189
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Targeting cancer metabolism in the era of precision oncology
Stine, Z. E., Schug, Z. T., Salvino, J. M., & Dang, C. V. (2022) · Nature Reviews Drug Discovery
Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer
Cited by 1,189
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Isolation of Mesenchymal Stem Cells of Fetal or Maternal Origin from Human Placenta
in 't Anker, P. S., Scherjon, S. A., Kleijburg‐van der Keur, C., de Groot‐Swings, G. M. J. S., Claas, F. H. J., Fibbe, W. E., & Kanhai, H. H. H. (2004) · STEM CELLS
Mesenchymal stem cell researchPluripotent Stem Cells Research
Cited by 1,189
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CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature
Sphingolipid Metabolism and SignalingT-cell and B-cell Immunology
Cited by 1,189
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Influence of proline residues on protein conformation
MacArthur, M. W., & Thornton, J. M. (1991) · Journal of Molecular Biology
Protein Structure and DynamicsChemical Synthesis and Analysis
Cited by 1,189
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BrafV600E cooperates with Pten loss to induce metastatic melanoma
Dankort, D., Curley, D. P., Cartlidge, R. A., Nelson, B., Karnezis, A. N., Damsky Jr, W. E., You, M. J., DePinho, R. A., McMahon, M., & Bosenberg, M. (2009) · Nature Genetics
Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management
Cited by 1,189
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VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., & Greenberg, D. A. (2003) · Journal of Clinical Investigation
Angiogenesis and VEGF in CancerNeurogenesis and neuroplasticity mechanisms
Cited by 1,189
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Lipid-induced insulin resistance: unravelling the mechanism
Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2010) · The Lancet
Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins
Cited by 1,189
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Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
Lin, S., Staahl, B. T., Alla, R. K., & Doudna, J. A. (2014) · eLife
CRISPR and Genetic EngineeringRNA regulation and disease
Cited by 1,189
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Telomeres and Aging
Aubert, G., & Lansdorp, P. M. (2008) · Physiological Reviews
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms
Cited by 1,188
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Inference of Population Structure using Dense Haplotype Data
Lawson, D. J., Hellenthal, G., Myers, S., & Falush, D. (2012) · PLoS Genetics
Forensic and Genetic ResearchGenetic diversity and population structure
Cited by 1,188
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Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts
Frezza, C., Cipolat, S., & Scorrano, L. (2007) · Nature Protocols
Mitochondrial Function and PathologyAutophagy in Disease and Therapy
Cited by 1,188
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Inositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews
Ion channel regulation and functionIon Channels and Receptors
Cited by 1,188
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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H., Liu, L., Liu, Y., Yang, C., Xu, Y., et al. (2012) · Genes & Development
Epigenetics and DNA MethylationCancer, Hypoxia, and Metabolism
Cited by 1,188
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Detection and quantification of mutations in the plasma of patients with colorectal tumors
Diehl, F., Li, M., Dressman, D., He, Y., Shen, D., Szabo, S., Diaz, L. A., Goodman, S. N., David, K. A., Juhl, H., et al. (2005) · Proceedings of the National Academy of Sciences
Cancer Genomics and DiagnosticsGenetic factors in colorectal cancer
Cited by 1,188
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Structure of TPR Domain–Peptide Complexes
Scheufler, C., Brinker, A., Bourenkov, G., Pegoraro, S., Moroder, L., Bartunik, H., Hartl, F. U., & Moarefi, I. (2000) · Cell
Heat shock proteins researchProtein Structure and Dynamics
Cited by 1,188
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Architectural protein subclasses shape 3D organization of genomes during lineage commitment
Phillips-Cremins, J. E., Sauria, M. E. G., Sanyal, A., Gerasimova, T. I., Lajoie, B. R., Bell, J. S. K., Ong, C.-T., Hookway, T. A., Guo, C., Sun, Y., et al. (2013) · Cell
Genomics and Chromatin DynamicsChromatin Remodeling and Cancer
Cited by 1,187
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A Standardized Terminology for Describing Reproductive Development in Fishes
Brown-Peterson, N. J., Wyanski, D. M., Saborido-Rey, F., Macewicz, B. J., & Lowerre-Barbieri, S. K. (2011) · Marine and Coastal Fisheries
Reproductive biology and impacts on aquatic speciesFish Biology and Ecology Studies
Cited by 1,187
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A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons
Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., Hannon, G., & Abeliovich, A. (2007) · Science
MicroRNA in disease regulationNeurogenesis and neuroplasticity mechanisms
Cited by 1,187
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