Most cited biochemistry, genetics and molecular biology papers
- Verified
Meta-analysis of Risk Reduction Estimates Associated With Risk-Reducing Salpingo-oophorectomy in BRCA1 or BRCA2 Mutation Carriers
Rebbeck, T. R., Kauff, N. D., & Domchek, S. M. (2009) · JNCI Journal of the National Cancer Institute
BRCA gene mutations in cancerMultiple and Secondary Primary Cancers
Cited by 939
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Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J., Fredlund, E., Ringnér, M., Mörgelin, M., Bourseau-Guilmain, E., Bengzon, J., & Belting, M. (2013) · Proceedings of the National Academy of Sciences
Extracellular vesicles in diseaseAngiogenesis and VEGF in Cancer
Cited by 939
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Increased Taxon Sampling Greatly Reduces Phylogenetic Error
Zwickl, D. J., & Hillis, D. M. (2002) · Systematic Biology
Genomics and Phylogenetic StudiesEvolution and Paleontology Studies
Cited by 939
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Signaling pathways in insulin action: molecular targets of insulin resistance
Pessin, J. E., & Saltiel, A. R. (2000) · Journal of Clinical Investigation
Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins
Cited by 939
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Joint profiling of chromatin accessibility and gene expression in thousands of single cells
Cao, J., Cusanovich, D. A., Ramani, V., Aghamirzaie, D., Pliner, H. A., Hill, A. J., Daza, R. M., McFaline-Figueroa, J. L., Packer, J. S., Christiansen, L., et al. (2018) · Science
Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics
Cited by 938
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Clinical risk factors, DNA variants, and the development of type 2 diabetes
Lyssenko, V., Jonsson, A., Almgren, P., Pulizzi, N., Isomaa, B., Tuomi, T., Berglund, G., Altshuler, D., Nilsson, P., & Groop, L. (2008) · New England Journal of Medicine
Genetic Associations and EpidemiologyDiabetes and associated disorders
Cited by 938
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Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
Tsoi, J., Robert, L., Paraiso, K., Galvan, C., Sheu, K. M., Lay, J., Wong, D. J. L., Atefi, M., Shirazi, R., Wang, X., et al. (2018) · Cancer Cell
Ferroptosis and cancer prognosisMelanoma and MAPK Pathways
Cited by 938
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BiGG Models: A platform for integrating, standardizing and sharing genome-scale models
King, Z. A., Lu, J., Dräger, A., Miller, P., Federowicz, S., Lerman, J. A., Ebrahim, A., Palsson, B. O., & Lewis, N. E. (2016) · Nucleic Acids Research
Microbial Metabolic Engineering and BioproductionBioinformatics and Genomic Networks
Cited by 938
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Genomics, type 2 diabetes, and obesity
McCarthy, M. I. (2010) · New England Journal of Medicine
Genetic Associations and EpidemiologyDiabetes and associated disorders
Cited by 938
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Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules
Ohuchi, E., Imai, K., Fujii, Y., Sato, H., Seiki, M., & Okada, Y. (1997) · Journal of Biological Chemistry
Protease and Inhibitor MechanismsPeptidase Inhibition and Analysis
Cited by 938
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Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds
Zalatan, J. G., Lee, M. E., Almeida, R., Gilbert, L. A., Whitehead, E. H., La Russa, M., Tsai, J. C., Weissman, J. S., Dueber, J. E., Qi, L. S., et al. (2015) · Cell
CRISPR and Genetic EngineeringGene Regulatory Network Analysis
Cited by 938
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Differential abundance testing on single-cell data using k-nearest neighbor graphs
Dann, E., Henderson, N. C., Teichmann, S. A., Morgan, M. D., & Marioni, J. C. (2022) · Nature Biotechnology
Single-cell and spatial transcriptomicsGene expression and cancer classification
Cited by 938
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Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects
Sweeney, S. T., Broadie, K., Keane, J., Niemann, H., & O'Kane, C. J. (1995) · Neuron
Cellular transport and secretionNeurobiology and Insect Physiology Research
Cited by 938
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Transcriptional Regulatory Elements in the Human Genome
Maston, G. A., Evans, S. K., & Green, M. R. (2006) · Annual Review of Genomics and Human Genetics
Genomics and Chromatin DynamicsChromatin Remodeling and Cancer
Cited by 937
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Simulating 500 million years of evolution with a language model
Hayes, T., Rao, R., Akin, H., Sofroniew, N. J., Oktay, D., Lin, Z., Verkuil, R., Tran, V. Q., Deaton, J., Wiggert, M., et al. (2025) · Science
Protein Structure and DynamicsMachine Learning in Bioinformatics
Cited by 937
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JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles
Mathelier, A., Fornes, O., Arenillas, D. J., Chen, C.-Y., Denay, G., Lee, J., Shi, W., Shyr, C., Tan, G., Worsley-Hunt, R., et al. (2016) · Nucleic Acids Research
Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies
Cited by 937
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The 3D Genome as Moderator of Chromosomal Communication
Dekker, J., & Mirny, L. (2016) · Cell
Genomics and Chromatin DynamicsNuclear Structure and Function
Cited by 937
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Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science
Glycosylation and Glycoproteins ResearchDigestive system and related health
Cited by 936
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A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2
Schlacher, K., Wu, H., & Jasin, M. (2012) · Cancer Cell
DNA Repair MechanismsBRCA gene mutations in cancer
Cited by 936
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Fatty acid elongases in mammals: their regulation and roles in metabolism
JAKOBSSON, A., WESTERBERG, R., & JACOBSSON, A. (2006) · Progress in Lipid Research
Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism
Cited by 936
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Integrated detection and population-genetic analysis of SNPs and copy number variation
McCarroll, S. A., Kuruvilla, F. G., Korn, J. M., Cawley, S., Nemesh, J., Wysoker, A., Shapero, M. H., de Bakker, P. I. W., Maller, J. B., Kirby, A., et al. (2008) · Nature Genetics
Genomic variations and chromosomal abnormalitiesGenetic Associations and Epidemiology
Cited by 936
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Sources of estrogen and their importance
Simpson, E. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology
Estrogen and related hormone effectsMenopause: Health Impacts and Treatments
Cited by 936
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Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast
Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A. (2007) · Science
Microtubule and mitosis dynamicsFungal and yeast genetics research
Cited by 935
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The Polycystic Kidney Disease Proteins, Polycystin-1, Polycystin-2, Polaris, and Cystin, Are Co-Localized in Renal Cilia
Yoder, B. K., Hou, X., & Guay-Woodford, L. M. (2002) · Journal of the American Society of Nephrology
Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances
Cited by 935
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