Most cited biochemistry, genetics and molecular biology papers
- Verified
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell
RNA modifications and cancerRNA regulation and disease
Cited by 3,550
- Verified
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine
Extracellular vesicles in diseaseCellular transport and secretion
Cited by 3,546
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Robust relationship inference in genome-wide association studies
Manichaikul, A., Mychaleckyj, J. C., Rich, S. S., Daly, K., Sale, M., & Chen, W.-M. (2010) · Bioinformatics
Genetic Associations and EpidemiologyForensic and Genetic Research
Cited by 3,541
- Verified
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences
Inflammasome and immune disordersImmune Response and Inflammation
Cited by 3,539
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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell
Autophagy in Disease and TherapyCell death mechanisms and regulation
Cited by 3,536
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CADD: predicting the deleteriousness of variants throughout the human genome
Rentzsch, P., Witten, D., Cooper, G. M., Shendure, J., & Kircher, M. (2019) · Nucleic Acids Research
Genomics and Rare DiseasesGenetic Associations and Epidemiology
Cited by 3,534
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Preservation of Duplicate Genes by Complementary, Degenerative Mutations
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-L., & Postlethwait, J. (1999) · Genetics
Chromosomal and Genetic VariationsEvolution and Genetic Dynamics
Cited by 3,529
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TGF-β: the master regulator of fibrosis
Meng, X.-M., Nikolic-Paterson, D. J., & Lan, H. Y. (2016) · Nature Reviews Nephrology
TGF-β signaling in diseasesChronic Kidney Disease and Diabetes
Cited by 3,528
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The Extracellular Matrix: Not Just Pretty Fibrils
Hynes, R. O. (2009) · Science
Cellular Mechanics and InteractionsCell Adhesion Molecules Research
Cited by 3,527
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The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature
Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and Health
Cited by 3,525
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Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science
Muscle Physiology and DisordersUbiquitin and proteasome pathways
Cited by 3,521
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Oxidative Stress
Sies, H., Berndt, C., & Jones, D. P. (2017) · Annual Review of Biochemistry
Redox biology and oxidative stressGenomics, phytochemicals, and oxidative stress
Cited by 3,520
- Verified
Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature
NF-κB Signaling PathwaysSignaling Pathways in Disease
Cited by 3,519
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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature
Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism
Cited by 3,519
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ClinVar: public archive of relationships among sequence variation and human phenotype
Landrum, M. J., Lee, J. M., Riley, G. R., Jang, W., Rubinstein, W. S., Church, D. M., & Maglott, D. R. (2014) · Nucleic Acids Research
Genomics and Rare DiseasesGenetic Associations and Epidemiology
Cited by 3,516
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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Subramanian, A., Narayan, R., Corsello, S. M., Peck, D. D., Natoli, T. E., Lu, X., Gould, J., Davis, J. F., Tubelli, A. A., Asiedu, J. K., et al. (2017) · Cell
Gene expression and cancer classificationBioinformatics and Genomic Networks
Cited by 3,515
- Verified
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
Du, C., Fang, M., Li, Y., Li, L., & Wang, X. (2000) · Cell
Cell death mechanisms and regulationUbiquitin and proteasome pathways
Cited by 3,513
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature
Genomics and Chromatin DynamicsSirtuins and Resveratrol in Medicine
Cited by 3,510
- Verified
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell
Autophagy in Disease and TherapyEndoplasmic Reticulum Stress and Disease
Cited by 3,506
- Verified
Crosstalk of reactive oxygen species and NF-κB signaling
Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research
NF-κB Signaling PathwaysRedox biology and oxidative stress
Cited by 3,505
- Verified
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature
Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms
Cited by 3,500
- Verified
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology
Inflammasome and immune disordersImmune Response and Inflammation
Cited by 3,500
- Verified
The repertoire of mutational signatures in human cancer
Alexandrov, L. B., Kim, J., Haradhvala, N. J., Huang, M. N., Tian Ng, A. W., Wu, Y., Boot, A., Covington, K. R., Gordenin, D. A., Bergstrom, E. N., et al. (2020) · Nature
Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer
Cited by 3,496
- Verified
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell
CRISPR and Genetic EngineeringAnimal Genetics and Reproduction
Cited by 3,495
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