Check pharmacology, toxicology and pharmaceutics papers: citations, claims and retractions

Reproducing human and cross-species drug toxicities using a liver-chip

Jang, K.-J., Otieno, M. A., Ronxhi, J., Lim, H.-K., Ewart, L., Kodella, K. R., Petropolis, D. B., Kulkarni, G., Rubins, J. E., Conegliano, D., et al. (2019) · Science Translational Medicine

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 511

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions

Fattinger, K. (2001) · Clinical Pharmacology & Therapeutics

Drug-Induced Hepatotoxicity and ProtectionDrug Transport and Resistance Mechanisms

Cited by 509

Effects of the Antifungal Agents on Oxidative Drug Metabolism: Clinical Relevance

Venkatakrishnan, K., von Moltke, L. L., & Greenblatt, D. J. (2000) · Clinical Pharmacokinetics

Pharmacogenetics and Drug MetabolismAntifungal resistance and susceptibility

Cited by 508

Scoring functions and their evaluation methods for protein-ligand docking: recent advances and future directions.

Huang, S.-Y., Grinter, S. Z., & Zou, X. (2010) · Physical Chemistry Chemical Physics

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 508

Phenotypic screening in cancer drug discovery — past, present and future

Moffat, J. G., Rudolph, J., & Bailey, D. (2014) · Nature Reviews Drug Discovery

Computational Drug Discovery MethodsCancer Cells and Metastasis

Cited by 507

Size-Dependent Bioadhesion of Micro- and Nanoparticulate Carriers to the Inflamed Colonic Mucosa

Lamprecht, A., Schäfer, U., & Lehr, C.-M. (2001) · Pharmaceutical Research

Advanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

Cited by 507

Human cytochromes P450 in health and disease

Nebert, D. W., Wikvall, K., & Miller, W. L. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences

Pharmacogenetics and Drug MetabolismEicosanoids and Hypertension Pharmacology

Cited by 505

Clinical pharmacokinetics of tyrosine kinase inhibitors

van Erp, N. P., Gelderblom, H., & Guchelaar, H.-J. (2009) · Cancer Treatment Reviews

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 503

The diverse functionality of NQO1 and its roles in redox control

Ross, D., & Siegel, D. (2021) · Redox Biology

Bioactive Compounds and Antitumor AgentsGenomics, phytochemicals, and oxidative stress

Cited by 499

Inconsistency in large pharmacogenomic studies

Haibe-Kains, B., El-Hachem, N., Birkbak, N. J., Jin, A. C., Beck, A. H., Aerts, H. J. W. L., & Quackenbush, J. (2013) · Nature

Computational Drug Discovery MethodsCancer Genomics and Diagnostics

Cited by 499

Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds

Proschak, E., Stark, H., & Merk, D. (2019) · Journal of Medicinal Chemistry

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 498

The Vaccine Adverse Event Reporting System (VAERS)

CHEN, R., RASTOGI, S., MULLEN, J., HAYES, S., COCHI, S., DONLON, J., & WASSILAK, S. (1994) · Vaccine

Pharmacovigilance and Adverse Drug ReactionsData-Driven Disease Surveillance

Cited by 498

Flexible ligand docking to multiple receptor conformations: a practical alternative

Totrov, M., & Abagyan, R. (2008) · Current Opinion in Structural Biology

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 497

REINVENT 2.0: An AI Tool for De Novo Drug Design

Blaschke, T., Arús-Pous, J., Chen, H., Margreitter, C., Tyrchan, C., Engkvist, O., Papadopoulos, K., & Patronov, A. (2020) · Journal of Chemical Information and Modeling

Computational Drug Discovery MethodsMachine Learning in Materials Science

Cited by 496

Metformin pathways: pharmacokinetics and pharmacodynamics

Gong, L., Goswami, S., Giacomini, K. M., Altman, R. B., & Klein, T. E. (2012) · Pharmacogenetics and Genomics

Pharmacogenetics and Drug MetabolismMetabolism, Diabetes, and Cancer

Cited by 495

Forging the basis for developing protein-ligand interaction scoring functions.

Liu, Z., Su, M., Han, L., Liu, J., Yang, Q., Li, Y., & Wang, R. (2017) · Accounts of Chemical Research

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 493

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

Kubo, A., Nagao, K., Yokouchi, M., Sasaki, H., & Amagai, M. (2009) · Journal of Experimental Medicine

Advancements in Transdermal Drug DeliveryImmunotherapy and Immune Responses

Cited by 491

Female sex and oral contraceptive use accelerate nicotine metabolism

BENOWITZ, N., LESSOVSCHLAGGAR, C., SWAN, G., & JACOBIII, P. (2006) · Clinical Pharmacology & Therapeutics

Pharmacogenetics and Drug MetabolismSmoking Behavior and Cessation

Cited by 486

Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State

Mudie, D. M., Murray, K., Hoad, C. L., Pritchard, S. E., Garnett, M. C., Amidon, G. L., Gowland, P. A., Spiller, R. C., Amidon, G. E., & Marciani, L. (2014) · Molecular Pharmaceutics

Drug Solubulity and Delivery SystemsGastrointestinal motility and disorders

Cited by 486

Drug-Induced Liver Injury Network (DILIN) Prospective Study: Rationale, Design and Conduct

Fontana, R. J., Watkins, P. B., Bonkovsky, H. L., Chalasani, N., Davern, T., Serrano, J., & Rochon, J. (2009) · Drug Safety

Drug-Induced Hepatotoxicity and ProtectionPharmacovigilance and Adverse Drug Reactions

Cited by 486

From genome to “venome”: Molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins

Fry, B. G. (2005) · Genome Research

Venomous Animal Envenomation and StudiesAmphibian and Reptile Biology

Cited by 486

Can We Learn To Distinguish between “Drug-like” and “Nondrug-like” Molecules?

Ajay, Walters, W. P., & Murcko, M. A. (1998) · Journal of Medicinal Chemistry

Computational Drug Discovery MethodsMachine Learning in Materials Science

Cited by 484

Limit of detection (LQD)/limit of quantitation (LOQ): comparison of the empirical and the statistical methods exemplified with GC-MS assays of abused drugs

Armbruster, D. A., Tillman, M. D., & Hubbs, L. M. (1994) · Clinical Chemistry

Forensic Toxicology and Drug AnalysisAnalytical Methods in Pharmaceuticals

Cited by 483

Anticancer potential of alkaloids: A key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Dhyani, P., Quispe, C., Sharma, E., Bahukhandi, A., Sati, P., Attri, D. C., Szopa, A., Sharifi-Rad, J., Docea, A. O., Mardare, I., et al. (2022) · Cancer Cell International

Alkaloids: synthesis and pharmacologyBerberine and alkaloids research

Cited by 483