Check pharmacology, toxicology and pharmaceutics papers: citations, claims and retractions

Synthon-based ligand discovery in virtual libraries of over 11 billion compounds

Sadybekov, A. A., Sadybekov, A. V., Liu, Y., Iliopoulos-Tsoutsouvas, C., Huang, X.-P., Pickett, J., Houser, B., Patel, N., Tran, N. K., Tong, F., et al. (2022) · Nature

Computational Drug Discovery MethodsChemical Synthesis and Analysis

Cited by 417

Why Drugs Fail - A Study on Side Effects in New Chemical Entities

Schuster, D., Laggner, C., & Langer, T. (2005) · Current Pharmaceutical Design

Pharmacovigilance and Adverse Drug ReactionsStatistical Methods in Clinical Trials

Cited by 417

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

Patten, C. J., Thomas, P. E., Guy, R. L., Lee, M., Gonzalez, F. J., Guengerich, F. P., & Yang, C. S. (1993) · Chemical Research in Toxicology

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 417

Stratum corneum lipids: the effect of ageing and the seasons

Rogers, J., Harding, C., Mayo, A., Banks, J., & Rawlings, A. (1996) · Archives of Dermatological Research

Advancements in Transdermal Drug DeliveryDermatology and Skin Diseases

Cited by 415

N -acetylcysteine for antioxidant therapy: pharmacology and clinical utility

Dodd, S., Dean, O., Copolov, D. L., Malhi, G. S., & Berk, M. (2008) · Expert Opinion on Biological Therapy

Drug-Induced Hepatotoxicity and ProtectionSulfur Compounds in Biology

Cited by 413

Snake venom l-amino acid oxidases

Du, X.-Y., & Clemetson, K. J. (2002) · Toxicon

Venomous Animal Envenomation and StudiesHealthcare and Venom Research

Cited by 413

DGIdb 2.0: mining clinically relevant drug–gene interactions

Wagner, A. H., Coffman, A. C., Ainscough, B. J., Spies, N. C., Skidmore, Z. L., Campbell, K. M., Krysiak, K., Pan, D., McMichael, J. F., Eldred, J. M., et al. (2016) · Nucleic Acids Research

Pharmacogenetics and Drug MetabolismComputational Drug Discovery Methods

Cited by 413

Silicon micromachined hollow microneedles for transdermal liquid transport

Gardeniers, H. J. G. E., Luttge, R., Berenschot, E. J. W., de Boer, M. J., Yeshurun, S. Y., Hefetz, M., van-t Oever, R., & van den Berg, A. (2003) · Journal of Microelectromechanical Systems

Advancements in Transdermal Drug DeliveryMicrofluidic and Capillary Electrophoresis Applications

Cited by 413

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Austin, R. P., Barton, P., Cockroft, S. L., Wenlock, M. C., & Riley, R. J. (2002) · Drug Metabolism and Disposition

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 413

In situ forming parenteral drug delivery systems: an overview

Packhaeuser, C. B., Schnieders, J., Oster, C. G., & Kissel, T. (2004) · European Journal of Pharmaceutics and Biopharmaceutics

Advanced Drug Delivery SystemsHydrogels: synthesis, properties, applications

Cited by 413

Why do we need so many chemical similarity search methods?

Sheridan, R. (2002) · Drug Discovery Today

Computational Drug Discovery MethodsSynthesis and Characterization of Heterocyclic Compounds

Cited by 412

Bleomycin‐induced strand‐scission of DNA. Mechanism of deoxyribose cleavage

Giloni, L., Takeshita, M., Johnson, F., Iden, C., & Grollman, A. P. (1981) · Journal of Biological Chemistry

Bioactive Compounds and Antitumor AgentsDNA and Nucleic Acid Chemistry

Cited by 412

Application of Generative Autoencoder in De Novo Molecular Design

Blaschke, T., Olivecrona, M., Engkvist, O., Bajorath, J., & Chen, H. (2018) · Molecular Informatics

Computational Drug Discovery MethodsMachine Learning in Materials Science

Cited by 411

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

Moore, M., Thor, H., Moore, G., Nelson, S., Moldéus, P., & Orrenius, S. (1985) · Journal of Biological Chemistry

Drug-Induced Hepatotoxicity and ProtectionBioactive Compounds and Antitumor Agents

Cited by 410

Potential developmental neurotoxicity of pesticides used in Europe

Bjørling-Poulsen, M., Andersen, H. R., & Grandjean, P. (2008) · Environmental Health

Pesticide Exposure and ToxicityAgricultural safety and regulations

Cited by 407

FDA-approved drug labeling for the study of drug-induced liver injury

Chen, M., Vijay, V., Shi, Q., Liu, Z., Fang, H., & Tong, W. (2011) · Drug Discovery Today

Drug-Induced Hepatotoxicity and ProtectionPharmacovigilance and Adverse Drug Reactions

Cited by 406

Preparation of poly(dl-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method

Murakami, H., Kobayashi, M., Takeuchi, H., & Kawashima, Y. (1999) · International Journal of Pharmaceutics

Advanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

Cited by 405

Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 1: Ways to make an impact, and why we are not there yet

Bender, A., & Cortés-Ciriano, I. (2021) · Drug Discovery Today

Computational Drug Discovery MethodsArtificial Intelligence in Healthcare and Education

Cited by 405

Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

Boelsterli, U. (2003) · Toxicology and Applied Pharmacology

Drug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug Metabolism

Cited by 403

Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC

Tarazona, J. V., Court-Marques, D., Tiramani, M., Reich, H., Pfeil, R., Istace, F., & Crivellente, F. (2017) · Archives of Toxicology

Pesticide Exposure and ToxicityAgricultural safety and regulations

Cited by 402

Stealth PLA-PEG nanoparticles as protein carriers for nasal administration

Tobío, M., Gref, R., Sánchez, A., Langer, R., & Alonso, M. J. (1998) · Pharmaceutical Research

Advanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

Cited by 402

Progress in brain targeting drug delivery system by nasal route

Khan, A. R., Liu, M., Khan, M. W., & Zhai, G. (2017) · Journal of Controlled Release

Advanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

Cited by 402

Targeting protein–protein interactions as an anticancer strategy

Ivanov, A. A., Khuri, F. R., & Fu, H. (2013) · Trends in Pharmacological Sciences

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 401

Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting

Frey, A., Giannasca, K. T., Weltzin, R., Giannasca, P. J., Reggio, H., Lencer, W. I., & Neutra, M. R. (1996) · The Journal of experimental medicine

Advanced Drug Delivery SystemsGlycosylation and Glycoproteins Research

Cited by 401