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Cited by 272

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Low Testosterone Levels and the Risk of Anemia in Older Men and Women

Open access
Ferrucci, Luigi, Maggio, Marcello, Bandinelli, Stefania, Basaria, Shehzad, Lauretani, Fulvio, Ble, Alessandro, Valenti, Giorgio, Ershler, William B., Guralnik, Jack M., Longo, Dan L.·2006·Archives of Internal Medicine
DOI 10.1001/archinte.166.13.1380
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Abstract

BACKGROUND: Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia. METHODS: Testosterone and hemoglobin levels were measured in a representative sample of 905 persons 65 years or older without cancer, renal insufficiency, or anti-androgenic treatments. Hemoglobin levels were reassessed after 3 years. RESULTS: At baseline, 31 men and 57 women had anemia. Adjusting for confounders, we found that total and bioavailable testosterone levels were associated with hemoglobin levels in women (P = .001 and P = .02, respectively) and in men (P<.001 and P = .03, respectively). Men and women in the lowest quartile of total and bioavailable testosterone were more likely than those in the highest to have anemia (men, 14/99 vs 3/100; odds ratio [OR], 5.4; 95% confidence interval [CI], 1.4-21.8 for total and 16/99 vs 1/99; OR, 13.1; 95% CI, 1.5-116.9 for bioavailable testosterone; women, 21/129 vs 12/127; OR, 2.1; 95% CI, 0.9-5.0 for total and 24/127 vs 6/127; OR, 3.4; 95% CI, 1.2-9.4 for bioavailable testosterone). Among nonanemic participants and independent of confounders, men and women with low vs normal total and bioavailable testosterone levels had a significantly higher risk of developing anemia at 3-year follow-up (21/167 vs 28/444; relative risk, 2.1; 95% CI, 1.1-4.1 for total and 26/143 vs 23/468; relative risk, 3.9; 95% CI, 1.9-7.8 for bioavailable testosterone). CONCLUSION: Older men and women with low testosterone levels have a higher risk of anemia.

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Metadata

Authors
Ferrucci, L., Maggio, M., Bandinelli, S., Basaria, S., Lauretani, F., Ble, A., Valenti, G., Ershler, W. B., Guralnik, J. M., & Longo, D. L.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2006-07-10
Volume
166
Issue
13
Pages
1380
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.166.13.1380
OpenAlex
W2165977461
Cited by
272
References
5
FWCI
8.47
Type
journal article
Language
en
Open access
green

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