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Cited by 313Autism Spectrum Disorder ResearchTryptophan and brain disordersNeurotransmitter Receptor Influence on Behavior

Whole blood serotonin in autistic and normal subjects

Anderson, George M., Freedman, Daniel X., Cohen, Donald J., Volkmar, Fred R., Hoder, E. Lawrence, McPhedran, Peter, Minderaa, Ruud B., Hansen, Carl R. +1 more·1987·Journal of Child Psychology and Psychiatry
DOI 10.1111/j.1469-7610.1987.tb00677.x
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Abstract

Whole blood serotonin and tryptophan were measured in 87 normal subjects and in 40 autistic subjects. Whole blood serotonin concentrations (mean +/- SE) were significantly higher in drug-free (N = 21) autistics (205 +/- 16 ng/ml) than in normals (136 +/- 5.4 ng/ml). The Gaussian distribution of serotonin levels in the unmedicated autistic group suggests the elevation was not due to a subgroup of autistic subjects. Autistics medicated with anticonvulsants or neuroleptics had significantly lower serotonin levels than did drug-free autistic subjects. Whole blood tryptophan levels and platelet counts were similar in the autistic and normal groups. The possible causes of the hyperserotonemia of autism are discussed.

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Crossref · 10.1111/j.1469-7610.1987.tb00677.x

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  • In patients with ASD, altered function and metabolism of neurotransmitters such as 5-HT and catecholamines, and dysfunction of the serotonergic system, have been reported to contribute to symptomatology.

    “In patients with ASD, altered function and metabolism of neurotransmitters, such as 5′-HT and catecholamines, and dysfunction of the serotonergic system have been reported to contribute to symptomatology [188,192,193,194,195,196].”

    From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [195]

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Authors
Anderson, G. M., Freedman, D. X., Cohen, D. J., Volkmar, F. R., Hoder, E. L., McPhedran, P., Minderaa, R. B., Hansen, C. R., & Young, J. G.
Affiliations
  • University of California, Los Angeles (US)
  • Yale University (US)
Corresponding author
Anderson, George M.
ORCID
Venue
Journal of Child Psychology and Psychiatry
Publisher
Wiley
Published
1987-11
Volume
28
Issue
6
Pages
885-900
ISSN
  • 0021-9630 (ISSN-L)
  • 1469-7610
DOI
10.1111/j.1469-7610.1987.tb00677.x
OpenAlex
W2128971418
Cited by
313
References
52
Citations by year
2026: 2 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 15 · 2012: 12
FWCI
4.65
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6976 d)
Locations
  • Journal of Child Psychology and Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH-24393, MH30929)
  • National Center for Research Resources (RR00125)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
autism spectrum disorder, whole blood serotonin, tryptophan, hyperserotonemia, antiepileptic drugs, antipsychotic drugs, platelet count
MeSH terms
Adolescent, Adult, Anticonvulsants, Autistic Disorder, Blood Platelets, Child, Child, Preschool, Chromatography, High Pressure Liquid, Female, Haloperidol, Humans, Infant, Male, Platelet Count, Serotonin, Sex Factors, Thioridazine, Tryptophan

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