The combined role of serotonin and interleukin-6 as biomarker for autism
Abstract
Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors. Diagnosis of autism is currently phenotype based with no reliable laboratory test available to assist clinicians. It has been shown that dysfunction of serotonin (5-HT) and interleukin-6 (IL-6) are involved in autism. The goal of this study was to evaluate the combined role of 5-HT and IL-6 as potential biomarkers for autism. The whole blood concentration of 5-HT and plasma concentration of IL-6 of individuals with autism were significantly elevated compared with the control group, and the concentration of 5-HT and IL-6 had positive correlations with the severity of autism. The results of receiver operating characteristic (ROC) analysis indicated that the combination of 5-HT and IL-6 produced the best sensitivity and specificity for diagnosis of autism. Therefore, the present study has revealed a simple clinical method with great potential for assisting the diagnosis of autism.
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We failed to replicate the recent report of a correlation between whole blood 5-HT levels and IL-6 levels.
“We also failed to replicate the recent report of a correlation between whole blood 5-HT levels and IL-6 levels (Yang et al. 2015), with IL-6 similar to other reports (Ashwood et al. 2011; Masi et al. 2015).”
From Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder (2016) · cites this paper as Yang et al. 2015
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 114,103 · see citing works
DeLong, E. R., DeLong, D. M., & Clarke-Pearson, D. L. (1988) · Biometrics · doi:10.2307/2531595 · Cited by 22,649 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,769 · see citing works
Morbidity and Mortality Weekly Report
Hiv/aids, N. B. (2011) · Wilderness and Environmental Medicine · doi:10.1016/j.wem.2010.11.007 · Cited by 3,431 · see citing works
Global Prevalence of Autism and Other Pervasive Developmental Disorders
Elsabbagh, M., Divan, G., Koh, Y., Kim, Y. S., Kauchali, S., Marcín, C., Montiel‐Nava, C., Patel, V., Paula, C. S., Wang, C., et al. (2012) · Autism Research · doi:10.1002/aur.239 · Cited by 2,636 · see citing works
Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS)
Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. (1980) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02408436 · Cited by 2,432 · cited 1× · see citing works
“An individual with a CARS score P 30 is considered to have autism (Schopler et al., 1980).”
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · cited 4× · see citing works
“have demonstrated that IL-6 was increased in the anterior cingulated gyrus of autistic brains and also in the cerebrospinal fluid of autistic children (Vargas et al., 2005).”
InfluentialIdentification and Evaluation of Children With Autism Spectrum Disorders
Johnson, C. P., Myers, S. M., & and the Council on Children With Disabilities (2007) · Pediatrics · doi:10.1542/peds.2007-2361 · Cited by 2,011 · see citing works
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940 · see citing works
Elevated immune response in the brain of autistic patients
Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X.-M., Ji, L., Brown, T., & Malik, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.002 · Cited by 786 · see citing works
Rose‐John, S., Scheller, J., Elson, G., & Jones, S. A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1105674 · Cited by 647 · see citing works
The Rise in Autism and the Role of Age at Diagnosis
Hertz-Picciotto, I., & Delwiche, L. (2009) · Epidemiology · doi:10.1097/ede.0b013e3181902d15 · Cited by 522 · see citing works
Serotonin and brain development: role in human developmental diseases
Whitaker-Azmitia, P. M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00615-3 · Cited by 506 · see citing works
Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys
Chugani, D. C., Muzik, O., Rothermel, R., Behen, M. E., Chakraborty, P. K., Mangner, T. J., Silva, E. A. D., & Chugani, H. T. (1997) · Annals of Neurology · doi:10.1002/ana.410420420 · Cited by 399 · see citing works
Interleukin-6 expression and regulation in astrocytes
Wagoner, N. J. V., & Benveniste, E. N. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00187-3 · Cited by 363 · see citing works
Brain Serotonin and Dopamine Transporter Bindings in Adults With High-Functioning Autism
Nakamura, K., Sekine, Y., Ouchi, Y., Tsujii, M., Yoshikawa, E., Futatsubashi, M., Tsuchiya, K. J., Sugihara, G., Iwata, Y., Suzuki, K., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.137 · Cited by 352 · see citing works
Blood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis
Gabriele, S., Sacco, R., & Persico, A. M. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.02.004 · Cited by 346 · see citing works
Veenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., Cohen, J., Mannangatti, P., Jessen, T., Thompson, B. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112345109 · Cited by 333 · see citing works
Wei, H., Zou, H., Sheikh, A. M., Malik, M., Dobkin, C., Brown, W. T., & Li, X. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-52 · Cited by 333 · see citing works
Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
Goines, P. E., & Ashwood, P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.006 · Cited by 314 · see citing works
Warner-Schmidt, J. L., Vanover, K. E., Chen, E. Y., Marshall, J. J., & Greengard, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104836108 · Cited by 291 · see citing works
PEPE, M. S., Cai, T., & Longton, G. (2005) · Biometrics · doi:10.1111/j.1541-0420.2005.00420.x · Cited by 278 · see citing works
Ashwood, P., Enstrom, A., Krakowiak, P., Hertz-Picciotto, I., Hansen, R. L., Croen, L. A., Ozonoff, S., Pessah, I. N., & de Water, J. V. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.07.006 · Cited by 271 · see citing works
Hyperserotonemia and amine metabolites in autistic and retarded children
Hanley, H. G. (1977) · Archives of General Psychiatry · doi:10.1001/archpsyc.1977.01770170031002 · Cited by 230 · see citing works
Low-grade endotoxemia in patients with severe autism
Emanuele, E., Orsi, P., Boso, M., Broglia, D., Brondino, N., Barale, F., di Nemi, S. U., & Politi, P. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.033 · Cited by 225 · see citing works
Mulder, E. J., Anderson, G. M., Kema, I. P., de Bildt, A., van Lang, N. D., den Boer, J. A., & Minderaa, R. B. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200404000-00016 · Cited by 199 · see citing works
Leboyer, M., Philippe, A., Bouvard, M., Guilloud-Bataille, M., Bondoux, D., Tabuteau, F., Feingold, J., Mouren-Simeoni, M.-C., & Launay, J.-M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00532-5 · Cited by 194 · see citing works
Serotonin: Synthesis and Release from the Myenteric Plexus of the Mouse Intestine
Gershon, M. D., Drakontides, A. B., & Ross, L. L. (1965) · Science · doi:10.1126/science.149.3680.197 · Cited by 186 · see citing works
Abdallah, M. W., Larsen, N., Grove, J., Nørgaard-Pedersen, B., Thorsen, P., Mortensen, E. L., & Hougaard, D. M. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.639803 · Cited by 186 · see citing works
Serotonin and dopamine transporter binding in children with autism determined by SPECT
Makkonen, I., Riikonen, R., Kokki, H., Airaksinen, M. M., & Kuikka, J. T. (2008) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2008.03027.x · Cited by 169 · see citing works
Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder
Cook, E. H., Arora, R. C., Anderson, G. M., Berry‐Kravis, E., Yan, S., Yeoh, H. C., Sklena, P. J., Charak, D., & LEVENTHAL, B. L. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90685-v · Cited by 166 · see citing works
Altered Cytokine and BDNF Levels in Autism Spectrum Disorder
Ricci, S., Businaro, R., Ippoliti, F., Vasco, V. R. L., Massoni, F., Onofri, E., Troili, G. M., Pontecorvi, V., Morelli, M., Ricciardi, M. R., et al. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9393-4 · Cited by 165 · see citing works
Liquid-chromatographic determination of serotonin and tryptophan in whole blood and plasma.
Anderson, G. M., Young, J. G., Cohen, D. J., Schlicht, K. R., & Patel, N. (1981) · Clinical Chemistry · doi:10.1093/clinchem/27.5.775 · Cited by 148 · see citing works
Autism in Fetal Alcohol Syndrome: A Report of Six Cases
Nanson, J. L. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb01417.x · Cited by 147 · see citing works
Decreased serum levels of transforming growth factor-β1 in patients with autism
Okada, K., Hashimoto, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K. J., Sekine, Y., Suda, S., Suzuki, K., Sugihara, G.-I., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.08.020 · Cited by 132 · see citing works
Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder
Betancur, C., Corbex, M. A., Spielewoy, C., Philippe, A., Laplanche, J., Launay, J., Gillberg, C., Mouren-Siméoni, M., Hamon, M., Bruno Giros, A., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj/mp/4000923 · Cited by 125 · see citing works
Hyperserotonemia in Adults with Autistic Disorder
Hranilović, D., Bujas-Petković, Z., Vragović, R., Vuk, T., Hock, K., & Jernej, B. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0324-6 · Cited by 119 · see citing works
Azmitia, E. C., Singh, J. S., & Whitaker-Azmitia, P. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.002 · Cited by 107 · see citing works
McNamara, I. M., Borella, A., Bialowas‐McGoey, L. A., & Whitaker‐Azmitia, P. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.063 · Cited by 106 · see citing works
Autism and developmental abnormalities in children with perinatal cocaine exposure.
Davis, E., Fennoy, I., Laraque, D., Kanem, N., Brown, G., & Mitchell, J. (1992) · PubMed Central · Cited by 103 · see citing works
Principal pathogenetic components and biological endophenotypes in autism spectrum disorders
Sacco, R., Curatolo, P., Manzi, B., Militerni, R., Bravaccio, C., Frolli, A., Lenti, C., Saccani, M., Elia, M., Reichelt, K.-L., et al. (2010) · Autism Research · doi:10.1002/aur.151 · Cited by 102 · see citing works
Malik, M. N., Sheikh, A. M., Wen, G. Y., Spivack, W. D., Brown, W. T., & Li, X. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.03.001 · Cited by 92 · see citing works
Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder
Betancur, C., Corbex, M. A., Spielewoy, C., Philippe, A., Laplanche, J., Launay, J., Gillberg, C., Mouren-Siméoni, M., Hamon, M., Bruno Giros, A., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000923 · Cited by 90 · see citing works
Gallop, R., Crits-Christoph, P. F., Muenz, L. R., & Tu, X. M. (2003) · Understanding Statistics · doi:10.1207/s15328031us0204_01 · Cited by 86 · see citing works
Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells
Mahé, C., Loetscher, E., Dev, K. K., Bobirnac, I., Otten, U., & Schoeffter, P. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.025 · Cited by 79 · see citing works
Examining Autism Spectrum Disorders by Biomarkers: Example From the Oxytocin and Serotonin Systems
Hammock, E. A. D., Veenstra-VanderWeele, J. M., Yan, Z., Kerr, T. M., Morris, M., Anderson, G. M., Carter, C. S., Cook, E. H., & Jacob, S. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.04.010 · Cited by 79 · see citing works
Mostafa, G. A., & AL-Ayadhi, L. Y. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-71 · Cited by 60 · see citing works
Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice
Tian, Y., Graf, R., El‐Badry, A. M., Lesurtel, M., Furrer, K., Moritz, W., & Clavien, P. (2010) · Hepatology · doi:10.1002/hep.23960 · Cited by 59 · see citing works
Rose’Meyer, R. B. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-37 · Cited by 56 · see citing works
El-Ansary, A. K., Bacha, A. G. B., & AL-Ayadhi, L. Y. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-142 · Cited by 50 · see citing works
Relationship between whole blood serotonin and repetitive behaviors in autism
Kolevzon, A., Newcorn, J. H., Kryzak, L., Chaplin, W., Watner, D., Hollander, E., Smith, C. J., Cook, E. H., & Silverman, J. M. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.02.008 · Cited by 50 · see citing works
Effect of a Serotonin Receptor Antagonist on Interleukin-6-Induced Pulmonary Hypertension in Rats
Miyata, M., Ito, M., Sasajima, T., Ohira, H., & Kasukawa, R. (2001) · CHEST Journal · doi:10.1378/chest.119.2.554 · Cited by 45 · see citing works
Origin of the blood hyperserotonemia of autism
Janušonis, S. (2008) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-5-10 · Cited by 38 · see citing works
Brief Report: Platelet-Poor Plasma Serotonin in Autism
Anderson, G. M., Hertzig, M. E., & McBride, P. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1371-1 · Cited by 32 · see citing works
Serotonin, cytokines, p11, and depression
Snyder, S. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106103108 · Cited by 16 · see citing works
Li, X., Ma, Y., Wu, X., Hao, Z., Yin, J., Shen, J., Li, X., Zhang, P., & Wang, H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.141 · Cited by 14 · see citing works
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Saghazadeh, A., Ataeinia, B., Keynejad, K., Abdolalizadeh, A., Hirbod‐Mobarakeh, A., & Rezaei, N. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.019 · Cited by 239 · see citing works
Northoff, G., Hirjak, D., Wolf, R. C., Magioncalda, P., & Martino, M. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0814-5 · Cited by 204 · see citing works
Russo, F. B., de Freitas, B. C. G., Pignatari, G. C., Fernandes, I. R., Sebat, J. L., Muotri, A. R., & Beltrão-Braga, P. C. B. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.021 · Cited by 202 · see citing works
Immune Dysregulation in Autism Spectrum Disorder: What Do We Know about It?
Robinson-Agramonte, M. D. L. A., Noris García, E., Fraga Guerra, J., Vega Hurtado, Y., Antonucci, N., Semprún-Hernández, N., Schultz, S., & Siniscalco, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063033 · Cited by 176 · see citing works
Theoharides, T., Stewart, J. M., Hatziagelaki, E., & Kolaitis, G. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00225 · Cited by 145 · see citing works
Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?
Gładysz, D., Krzywdzińska, A., & Hozyasz, K. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0822-x · Cited by 130 · see citing works
Cattane, N., Richetto, J., & Cattaneo, A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.001 · Cited by 118 · see citing works
Prata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115 · see citing works
Sauer, A. K., Bockmann, J., Steinestel, K., Boeckers, T. M., & Grabrucker, A. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092134 · Cited by 98 · see citing works
Guo, M., Zhu, J., Yang, T., Lai, X., Liu, X., Liu, J., Chen, J., & Li, T. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.11.001 · Cited by 97 · see citing works
Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder
Marler, S., Ferguson, B. J., Lee, E. B., Peters, B., Williams, K. C., McDonnell, E., Macklin, E. A., Levitt, P., Gillespie, C. H., Anderson, G. M., et al. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2646-8 · Cited by 95 · see citing works
Do, P. Q. T., Huong, V. T., Phuong, N. T. T., Nguyen, H. T., Ta, H. K. T., Ju, H., Phan, T. B., Phung, V., Trinh, K. T. L., & Tran, N. H. T. (2020) · RSC Advances · doi:10.1039/d0ra05271j · Cited by 90 · see citing works
Ferguson, B. J., Marler, S., Altstein, L. L., Lee, E. B., Mazurek, M. O., McLaughlin, A., Macklin, E. A., McDonnell, E., Davis, D. J., Belenchia, A. M., et al. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.05.009 · Cited by 89 · see citing works
Nanomaterial based electrochemical sensing of the biomarker serotonin: a comprehensive review
Khoshnevisan, K., Maleki, H., Honarvarfard, E., Baharifar, H., Gholami, M., Faridbod, F., Larijani, B. A., Majidi, R. F., & Khorramizadeh, M. R. (2019) · Microchimica Acta · doi:10.1007/s00604-018-3069-y · Cited by 85 · see citing works
Serotonin and serotonin transporter levels in autistic children
Abdulamir, H. A., Abdul‐Rasheed, O. F., & Abdulghani, E. A. (2018) · Saudi Medical Journal · doi:10.15537/smj.2018.5.21751 · Cited by 80 · see citing works
Nadeem, A., Ahmad, S. F., Attia, S. M., AL-Ayadhi, L. Y., Al-Harbi, N. O., & Bakheet, S. A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109783 · Cited by 72 · see citing works
Diagnostic and Severity-Tracking Biomarkers for Autism Spectrum Disorder
Bjørklund, G., Meguid, N. A., El-Ansary, A. K., El‐Bana, M. A., Dadar, M., Aaseth, J., Hemimi, M., Osredkar, J., & Chirumbolo, S. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1192-1 · Cited by 51 · see citing works
El-Ansary, A. K., Cannell, J. J., Bjørklund, G., Bhat, R. S., Al-Dbass, A. M., Alfawaz, H., Chirumbolo, S., & AL-Ayadhi, L. Y. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0199-1 · Cited by 48 · see citing works
Research Progress in Vitamin A and Autism Spectrum Disorder
Liu, Z., Wang, J., Xu, Q., Hong, Q., Zhu, J., & Chi, X. (2021) · Behavioural Neurology · doi:10.1155/2021/5417497 · Cited by 49 · see citing works
The Contribution of Inflammation to Autism Spectrum Disorders: Recent Clinical Evidence
Prata, J., Machado, A. S., von Doellinger, O., Almeida, M. I., Barbosa, M. A., Coelho, R. C., & Santos, S. G. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9554-7_29 · Cited by 46 · see citing works
Cruz‐Machado, S. D. S., Campos, L. M. G., Fadini, C. C., Anderson, G., Markus, R. P., & Pinato, L. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12715 · Cited by 45 · see citing works
Abruzzo, P. M., Ghezzo, A., Bolotta, A., Ferreri, C., Minguzzi, R., Vignini, A., Visconti, P., & Marini, M. (2015) · Disease Markers · doi:10.1155/2015/329607 · Cited by 42 · see citing works
Nour‐Eldine, W., Ltaief, S. M., Manaph, N. P. A., & Al‐Shammari, A. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.950275 · Cited by 39 · see citing works
Murakami, Y., Imamura, Y., Kasahara, Y., Yoshida, C., Momono, Y., Fang, K., Sakai, D., Konishi, Y., & Nishiyama, T. (2023) · Cells · doi:10.3390/cells12071087 · Cited by 36 · see citing works
Yang, C.-J., Tan, H.-P., Yang, F.-Y., Wang, H.-P., Liu, C., He, H., Sang, B., Zhu, X.-M., & Du, Y. (2015) · Research in Autism · doi:10.1016/j.rasd.2015.07.002 · Cited by 37 · see citing works
Self-citationLv, S., He, E., Luo, J., Liu, Y., Liang, W. J., Xu, S., Zhang, K., Yang, Y. F., Wang, M., Song, Y., et al. (2023) · Advanced Science · doi:10.1002/advs.202301828 · Cited by 29 · see citing works
Afridi, R., Seol, S., Kang, H. J., & Suk, K. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114532 · Cited by 29 · see citing works
Children as Biomarker Orphans: Progress in the Field of Pediatric Biomarkers
Shores, D. R., & Everett, A. D. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.08.077 · Cited by 30 · see citing works
Steinman, G. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109797 · Cited by 26 · see citing works
Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder
Casey, S., Carter, M., Looney, A.-M., Livingstone, V., Moloney, G. M., O’Keeffe, G. W., Taylor, R. S., Kenny, L. C., McCarthy, F. P., McCowan, L. M. E., et al. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05271-7 · Cited by 26 · see citing works
California Autism Prevalence by County and Race/Ethnicity: Declining Trends Among Wealthy Whites
Nevison, C. D., & Parker, W. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04460-0 · Cited by 25 · see citing works
Increased serum levels of macrophage migration inhibitory factor in autism spectrum disorders
Ning, J., Li, X., Shen, C., Zhang, Y., & Zhao, Q. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.11.015 · Cited by 24 · see citing works
Esposito, D., Cruciani, G., Zaccaro, L., Carlo, E. D., Spitoni, G. F., Manti, F., Carducci, C., Fiori, E., Leuzzi, V., & Pascucci, T. (2024) · Brain Sciences · doi:10.3390/brainsci14050481 · Cited by 23 · see citing works
Raghavan, R., Anand, N. S., Wang, G., Hong, X., Pearson, C., ZUCKERMAN, B. S., Xie, H., & Wang, X. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01992-0 · Cited by 22 · see citing works
Kumari, E., Velloso, F. J., Nasuhidehnavi, A., Somasundaram, A., Savanur, V. H., Buono, K. D., & Levison, S. W. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.03.019 · Cited by 22 · see citing works
El-Ansary, A. K., Alhakbany, M. A., Al-Dbass, A. M., Qasem, H., Al-Mazidi, S. H., Bhat, R. S., & AL-Ayadhi, L. Y. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01578-7 · Cited by 22 · see citing works
Velloso, F. J., Wadhwa, A., Kumari, E., Carcea, I., Bozdagi-Gunal, O., & Levison, S. W. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.12.015 · Cited by 24 · see citing works
Yıldırım, V., Şimşek, Ş., Çetin, İ., & Dokuyucu, R. (2023) · Medicina · doi:10.3390/medicina59111906 · Cited by 20 · see citing works
Liang, Z.-K., Xiong, W. G., Wang, C., Chen, L., Zou, X. G., Mai, J.-W., Dong, B., Guo, C., Xin, W., Luo, D., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.040 · Cited by 20 · see citing works
Clinical Phenotype of Depression Affects Interleukin-6 Synthesis
Zadka, Ł., Dzięgiel, P., Kulus, M., & Olajossy, M. (2017) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2016.0074 · Cited by 20 · see citing works
Chauhan, V. P. S., & Chauhan, A. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.04.010 · Cited by 16 · see citing works
Biomarkers for Autism Spectrum Disorders (ASD): A Meta-analysis
Ansel, A., Posen, Y., Ellis, R. W., Deutsch, L., Zisman, P. D., & Gesundheit, B. (2019) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10375 · Cited by 15 · see citing works
Erdoğan, M. A., Bozkurt, M. F., & Erbaş, O. (2022) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10248 · Cited by 15 · see citing works
Role of Biomarkers in Medicine
Wang, M., & Witzmann, F. A. (2016) · InTech eBooks · doi:10.5772/61449 · Cited by 15 · see citing works
Luhach, K., Kulkarni, G. T., Singh, V. P., & Sharma, B. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13459 · Cited by 14 · see citing works
A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis
Walker, S. J., Beavers, D. P., Fortunato, J. E., & Krigsman, A. (2016) · Scientific Reports · doi:10.1038/srep35820 · Cited by 12 · see citing works
Biomarkers-Directed Strategies to Treat Autism
El-Ansary, A. K., & Dera, H. S. A. (2016) · InTech eBooks · doi:10.5772/62566 · Cited by 11 · see citing works
Khoshnevisan, K., Chehrehgosha, M., Conant, M., Meftah, A. M., Baharifar, H., Ejtahed, H., Angoorani, P., Gholami, M., Sharifi, F., Maleki, H., et al. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15533 · Cited by 12 · see citing works
Overview of prospects for inflammation pathways in autism spectrum disorders
Turbé, H., Waeckel, L., & Déchelotte, B. (2019) · L Encéphale · doi:10.1016/j.encep.2019.09.006 · Cited by 11 · see citing works
Luhach, K., Kulkarni, G. T., Singh, V. P., & Sharma, B. (2022) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2022-004 · Cited by 10 · see citing works
Alterations in Plasma Cytokine Levels in Korean Children with Autism Spectrum Disorder
Shim, S., Ha, S., Choi, J. H., Kwon, H., & Cheon, K.-A. A. (2024) · Yonsei Medical Journal · doi:10.3349/ymj.2023.0362 · Cited by 10 · see citing works
Chen, Y., Xue, Y., Jia, L., Yang, M., Huang, G., & Xie, J. (2024) · Medicine · doi:10.1097/md.0000000000037284 · Cited by 11 · see citing works
Quan, L., Zhao, Y., Yi, J., Shi, X., Zhong, Y.-J., & Liu, L. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-020-00668-2 · Cited by 10 · see citing works
Fuentes-Albero, M., Mafla-España, M. A., Martı́nez-Raga, J., & Cauli, O. (2024) · Pathophysiology · doi:10.3390/pathophysiology31030028 · Cited by 10 · see citing works
Uyanık, K. Ç. P., Yiğin, A. K., Doğangün, B., & Seven, M. (2021) · Immunological Investigations · doi:10.1080/08820139.2020.1870489 · Cited by 8 · see citing works
Molani‐Gol, R., Alizadeh, M., Kheirouri, S., & Hamedi, F. (2023) · BMC Pediatrics · doi:10.1186/s12887-023-04445-9 · Cited by 10 · see citing works
Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism
Zuniga-Kennedy, M., Davoren, M., Shuffrey, L. C., Luna, R. A., Savidge, T., Prasad, V., Anderson, G. M., Veenstra-VanderWeele, J. M., & Williams, K. C. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05597-w · Cited by 7 · see citing works
Mou, Q.-H., Zhang, Q., Chen, L., Dai, Y., Wei, H., Jia, F., Hao, Y., Li, L., Zhang, J., Wu, L., et al. (2025) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-025-00892-7 · Cited by 9 · see citing works
Zeng, X., Fan, L., Qin, Q., Zheng, D., Wang, H., Li, M., Jiang, Y., Wang, H., Liu, H., Liang, S., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.042 · Cited by 5 · see citing works
Cory‐Slechta, D. A., Marvin, E., Welle, K. A., Goeke, C. M., Chalupa, D., Oberdörster, G., & Sobolewski, M. (2024) · NeuroToxicology · doi:10.1016/j.neuro.2024.07.004 · Cited by 5 · see citing works
Chen, Q., Sun, Y., Pan, N., Long, Y., Cao, Y., Luo, Y., Xin, K., Chen, P., Wang, Y., Shu, M., et al. (2026) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-026-03068-6 · Cited by 4 · see citing works
Volk, T., Lukito, S., Raduà, J., Luksch, H., Roessner, V., & Beyer, N. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03659-4 · Cited by 5 · see citing works
El-Ansary, A. K., AL-Ayadhi, L. Y., Alhakbany, M. A., Polyakova, V., & Suchkov, S. (2024) · International journal for autism challenges & solution. · doi:10.54878/c0yn1911 · Cited by 3 · see citing works
Alba, C., Herranz, C., Monroy, M. A., Aragón, A., Jurado, R., Díaz‐Regañón, D., Sánchez, C., Tolín, M., Miranda, C., Gómez-Taylor, B., et al. (2024) · Microorganisms · doi:10.3390/microorganisms12102006 · Cited by 2 · see citing works
Kumari, E., Velloso, F. J., & Levison, S. W. (2019) · OBM Neurobiology · doi:10.21926/obm.neurobiol.1902027 · Cited by 2 · see citing works
The development of animal models for autism: A gene-environment approach
Ranger, P. (2016) · doi:10.26686/wgtn.17019029.v1 · Cited by 2 · see citing works
Şenkal, E., Eryiğit, U., Bozkurt, M. F., Solmaz, V., & Erbaş, O. (2021) · Research Square · doi:10.21203/rs.3.rs-182999/v1 · Cited by 2 · see citing works
Descripción clínica y tratamiento del trastorno del espectro autista: una revisión teórica
Medina, C. M. A., & Peña, J. J. G. (2024) · Psicología y Salud · doi:10.25009/pys.v35i1.2950 · Cited by 1 · see citing works
THE CAUSAL LINK BETWEEN VACCINATION ADJUVANTS AND AUTISM
Prevenslik, T. (2019) · International Journal of Research -GRANTHAALAYAH · doi:10.29121/granthaalayah.v7.i6.2019.805 · Cited by 1 · see citing works
Perturbações do Espetro do Autismo: Fatores de Risco e Protetores
Santos, M. A. S. (2015) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/1875-9d80
Immune and inflammatory hypothesis in autism spectrum disorders
Turbé, H., Déchelotte, B., & Waeckel, L. (2018) · French Journal of Psychiatry · doi:10.1016/s2590-2415(19)30371-x
Velloso, F. J., Wadhwa, A., Kumari, E., Carcea, I., Bozdagi-Gunal, O., & Levison, S. W. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.18.456694
Pinto, M. M. V., Arisawa, E. Â. L. S., Lopes‐Martins, R. Á. B., & Raniero, L. J. (2021) · Research Society and Development · doi:10.33448/rsd-v10i10.18924
Blom, J. M. C., Ruggerini, C., Caroli, F., Ferreri, C., Masi, A., Rivi, V., Sarti, P., Rebecchi, M., & Arletti, C. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1608033
Ateş, B., Ayaroğlu, P., & Congoloğlu, M. (2025) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.70058 · Cited by 1 · see citing works
Scenna, M. S., Bej, E., Cesare, P., Persichitti, I., Cimini, A., d’Angelo, M., & Castelli, V. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1783888
Jun, T., Juan, C., Xin, L., Yingli, W., Guo, Y., Rui, H., & Wei, Z. H. (2026) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.70144
Yamashita, M., Shou, Q., Hamatani, S., Matsuzaki, H., Fujieda, M., Hirano, Y., Kagitani-Shimono, K., Okazawa, H., & Mizuno, Y. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03206-z
Ergün, M. T., Aydın, M., Tekdemir, R., Bayırlı, Ö., Gürses, K. M., Yalçın, M. U., Özalp, H., Artaç, H., Ceylan, A., Abuşoğlu, S., et al. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101370
- Authors
- Yang, C.-J., Liu, C.-L., Sang, B., Zhu, X.-M., & Du, Y.-J.
- Affiliations
- East China Normal University (CN)
- Fudan University (CN)
- Corresponding author
- Yang, C.-J.
- Du, Y.-J.
- ORCID
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 284
- Pages
- 290-296
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2109544488
- Cited by
- 80
- References
- 58
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 12 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 5
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- East China Normal University (7119297K)
- National Natural Science Foundation of China (81401130, 31371043)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, serotonin, interleukin-6, biomarkers, autism diagnosis, neurodevelopmental disorders, blood serotonin, autism severity, sensitivity and specificity
- MeSH terms
- Adolescent, Autistic Disorder, Blood Chemical Analysis, Child, Female, Humans, Male, Psychiatric Status Rating Scales, ROC Curve, Sensitivity and Specificity, Serotonin, Biomarkers, Interleukin-6, Area Under Curve
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