Cited by 80Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

The combined role of serotonin and interleukin-6 as biomarker for autism

Yang, C.-J., Liu, C.-L., Sang, B., Zhu, X.-M., Du, Y.-J.·2015·Neuroscience

Abstract

Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors. Diagnosis of autism is currently phenotype based with no reliable laboratory test available to assist clinicians. It has been shown that dysfunction of serotonin (5-HT) and interleukin-6 (IL-6) are involved in autism. The goal of this study was to evaluate the combined role of 5-HT and IL-6 as potential biomarkers for autism. The whole blood concentration of 5-HT and plasma concentration of IL-6 of individuals with autism were significantly elevated compared with the control group, and the concentration of 5-HT and IL-6 had positive correlations with the severity of autism. The results of receiver operating characteristic (ROC) analysis indicated that the combination of 5-HT and IL-6 produced the best sensitivity and specificity for diagnosis of autism. Therefore, the present study has revealed a simple clinical method with great potential for assisting the diagnosis of autism.

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Crossref · 10.1016/j.neuroscience.2014.10.011

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Authors
Yang, C.-J., Liu, C.-L., Sang, B., Zhu, X.-M., & Du, Y.-J.
Affiliations
  • East China Normal University (CN)
  • Fudan University (CN)
Corresponding author
  • Yang, C.-J.
  • Du, Y.-J.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2015-01
Volume
284
Pages
290-296
ISSN
0306-4522 (ISSN-L)
OpenAlex
W2109544488
Cited by
80
References
58
Citations by year
2026: 6 · 2025: 3 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 12 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 5
FWCI
3.16
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • East China Normal University (7119297K)
  • National Natural Science Foundation of China (81401130, 31371043)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
autism spectrum disorder, serotonin, interleukin-6, biomarkers, autism diagnosis, neurodevelopmental disorders, blood serotonin, autism severity, sensitivity and specificity
MeSH terms
Adolescent, Autistic Disorder, Blood Chemical Analysis, Child, Female, Humans, Male, Psychiatric Status Rating Scales, ROC Curve, Sensitivity and Specificity, Serotonin, Biomarkers, Interleukin-6, Area Under Curve

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