Cited by 70Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesCognitive Functions and Memory

Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: Altered working memory and BOLD response

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McAllister, Thomas W., McDonald, Brenna C., Flashman, Laura A., Ferrell, Richard B., Tosteson, Tor D., Yanofsky, Norman N., Grove, Margaret R., Saykin, Andrew J.·2011·International Journal of Psychophysiology

Abstract

Alterations in working memory (WM) are common after traumatic brain injury (TBI). Frontal catecholaminergic systems, including the alpha-2 adrenergic system, modulate WM function and may be affected in TBI. We hypothesized that administration of an alpha-2 adrenergic agonist might improve WM after mild TBI (MTBI). Thirteen individuals with MTBI 1month after injury and 14 healthy controls (HC) were challenged with guanfacine and placebo prior to administration of a verbal WM functional MRI task. Guanfacine was associated with improved WM performance in the MTBI but not the HC group. On guanfacine the MTBI group showed increased activation within a WM task-specific region of interest. Findings are consistent with the hypothesis that alterations in WM after MTBI may be improved with the alpha-2 agonist guanfacine.

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Crossref · 10.1016/j.ijpsycho.2011.06.022

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Research works printed but not linked: 3

  1. Delis DC Kramer JH Kaplan E Ober BA California Verbal Learning Test-Second Edition: Adult Version Manual 2000 The Psychological Corporation San Antonio, TX
  2. Kobori N Hu B Dash PK Altered adrenergic receptor signaling following brain injury contribures to dysfunction of the prefrontal cortex 2010 Neuroscience electronically published http://dx.doi.org/10.1016/j.neurosceince.2010.10.048 PMC3010433 20974230 · DOI
  3. The Psychological Corporation WAIS-III Wechsler Adult Intelligence Scale-Third Edition WMS-III Wechsler Memory Scale-Third Edition Technical Manual 1997 The Psychological Corporation San Antonio, TX

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Authors
McAllister, T. W., McDonald, B. C., Flashman, L. A., Ferrell, R. B., Tosteson, T. D., Yanofsky, N. N., Grove, M. R., & Saykin, A. J.
Affiliations
  • Dartmouth College (US)
  • Indiana University Indianapolis (US)
  • Dartmouth–Hitchcock Medical Center (US)
Corresponding author
McAllister, Thomas W.
Venue
International Journal of Psychophysiology
Publisher
Elsevier BV
Published
2011-10
Volume
82
Issue
1
Pages
107-114
ISSN
0167-8760 (ISSN-L)
OpenAlex
W2050629291
Cited by
70
References
56
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 5
FWCI
4.34
Type
journal article
Language
en
Open access
Locations
  • International Journal of Psychophysiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion)
Funders
  • Dartmouth College
  • National Institutes of Health
  • National Institute on Disability and Rehabilitation Research
  • National Cancer Institute (P30CA023108)
  • National Institute of Neurological Disorders and Stroke (R01-NS-40472-01, R01NS040472)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
mild traumatic brain injury, working memory, alpha-2 adrenergic agonists, guanfacine, BOLD signal, catecholaminergic system, frontal cortex, functional MRI, pharmacological challenge
MeSH terms
Adult, Brain, Brain Injuries, Brain Mapping, Cognition Disorders, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory Disorders, Memory, Short-Term, Neuropsychological Tests, Oxygen, Prospective Studies, Trauma Severity Indices, Guanfacine, Young Adult, Adrenergic alpha-2 Receptor Agonists

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