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Cited by 187Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

Delayed-response deficit induced by local injection of the α2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys

Li, Bao-Ming, Mei, Zhen-Tong·1994·Behavioral and Neural Biology
DOI 10.1016/s0163-1047(05)80034-2
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Abstract

Two young adult monkeys (Macaca mullata) were trained to perform a delayed-response task that required the monkeys to remember a cued spatial position (left or right) over a delay interval and then to make a response to the cued position. Local injection of the alpha 2-adrenergic antagonist yohimbine (10 micrograms in 2 microliters saline) into the dorsolateral prefrontal cortex (Walker's area 46 and area 9) impaired the performance of the delayed-response task, and it was without effect on the performance of the task if there was no delay between the cue and choice signals. The main performing error after injection of yohimbine was that the monkeys responded to uncued position with higher rate. Local injection of the alpha 1-adrenergic antagonist prazosin (10 microgram in 2 microliters saline) or the beta-adrenergic antagonist propranolol (10 micrograms in 2 microliters saline) into the same cortical areas induced no significant effect on the performance of the task. The present study suggests that prefrontal alpha 2-adrenoceptors play an important role in the spatial working memory in young adult monkeys.

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Crossref · 10.1016/s0163-1047(05)80034-2

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13 of 13 references verified0 citation errors · 0 not checkable

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  • Studies in animals indicate that norepinephrine engages predominantly α2-receptors in the PFC when the subject is alert and interested, while actions at α1-receptors and possibly β-receptors are predominant under stressful conditions.

    “Studies in animals indicate that NE engages predominantly α2-receptors in the PFC when the subject is alert and interested (Li and Mei, 1994), while actions at α1-receptors and possibly β-receptors are predominant under stressful conditions (Birnbaum et al., 2004; Ramos et al., 2005).”

    From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Li and Mei, 1994

  • Blockade of α2A-receptors in the monkey PFC with local yohimbine infusions markedly impairs PFC regulation of attention and behavior, inducing poor impulse control and locomotor hyperactivity.

    “Blockade of α2A-receptors in the monkey PFC with local yohimbine infusions markedly impairs PFC regulation of attention and behavior, inducing poor impulse control and locomotor hyperactivity (Li and Mei, 1994; Ma et al., 2005; Ma et al., 2003).”

    From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Li and Mei, 1994

  • Yohimbine blockade of α2-receptors in the PFC recreates the symptoms of ADHD: inducing locomotor hyperactivity, poor impulse control, and weaker working memory.

    “Conversely, yohimbine blockade of α2-receptors in the PFC recreates the symptoms of ADHD: inducing locomotor hyperactivity (Ma et al., 2005), poor impulse control (Ma et al., 2003), and weaker working memory (Li and Mei, 1994).”

    From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Li and Mei, 1994

  • Depletion of noradrenaline or blockade of α2A-receptors in the prefrontal cortex impairs working memory, whereas stimulation of postsynaptic α2A-receptors in the prefrontal cortex improves working memory performance.

    “Thus, either depletion of noradrenaline52 or blockade of α2A-receptors in the PFC53 impairs working memory, whereas stimulation of postsynaptic α2A-receptors in the PFC improves working memory performance52,56–58.”

    From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [53]

  • Levels of noradrenaline released during alert, non-stressed waking optimize working memory by engaging α2A-receptors, whereas high levels released during stress impair prefrontal cortex function by stimulating lower-affinity α1-receptors and β1-receptors.

    “As shown in FIG. 2, the levels of noradrenaline that are released during alert, non-stressed waking optimize working memory by engaging α2A-receptors52,53, whereas the high levels of noradrenaline that are released during stress impair PFC function by stimulating lower-affinity α1-receptors54 and β1-receptors55.”

    From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [53]

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Authors
Li, B.-M., & Mei, Z.-T.
Affiliations
Chinese Academy of Sciences (CN)
ORCID
Li, Bao-Ming
Venue
Behavioral and Neural Biology
Publisher
Elsevier BV
Published
1994-09
Volume
62
Issue
2
Pages
134-139
ISSN
0163-1047 (ISSN-L)
DOI
10.1016/s0163-1047(05)80034-2
OpenAlex
W2075473160
Cited by
186
References
15
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 9 · 2015: 13 · 2014: 7 · 2013: 13 · 2012: 8
FWCI
1.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioral and Neural Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
yohimbine, alpha2-adrenoceptors, dorsolateral prefrontal cortex, delayed response task, spatial working memory, prazosin, propranolol, alpha-blockers, beta-blockers
MeSH terms
Animals, Brain Mapping, Female, Macaca mulatta, Orientation, Prazosin, Propranolol, Psychomotor Performance, Reaction Time, Mental Recall, Yohimbine, Prefrontal Cortex, Receptors, Adrenergic, alpha-1, Receptors, Adrenergic, alpha-2

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