The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index; none of the 52 sources its claims cite is checked for support yet.
Gait speed and survival in older adults.
Open accessAbstract
CONTEXT: Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival. Physical performance measures, such as gait speed, might help account for variability, allowing clinicians to make more individualized estimates. OBJECTIVE: To evaluate the relationship between gait speed and survival. DESIGN, SETTING, AND PARTICIPANTS: Pooled analysis of 9 cohort studies (collected between 1986 and 2000), using individual data from 34,485 community-dwelling older adults aged 65 years or older with baseline gait speed data, followed up for 6 to 21 years. Participants were a mean (SD) age of 73.5 (5.9) years; 59.6%, women; and 79.8%, white; and had a mean (SD) gait speed of 0.92 (0.27) m/s. MAIN OUTCOME MEASURES: Survival rates and life expectancy. RESULTS: There were 17,528 deaths; the overall 5-year survival rate was 84.8% (confidence interval [CI], 79.6%-88.8%) and 10-year survival rate was 59.7% (95% CI, 46.5%-70.6%). Gait speed was associated with survival in all studies (pooled hazard ratio per 0.1 m/s, 0.88; 95% CI, 0.87-0.90; P < .001). Survival increased across the full range of gait speeds, with significant increments per 0.1 m/s. At age 75, predicted 10-year survival across the range of gait speeds ranged from 19% to 87% in men and from 35% to 91% in women. Predicted survival based on age, sex, and gait speed was as accurate as predicted based on age, sex, use of mobility aids, and self-reported function or as age, sex, chronic conditions, smoking history, blood pressure, body mass index, and hospitalization. CONCLUSION: In this pooled analysis of individual data from 9 selected cohorts, gait speed was associated with survival in older adults.
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“Stratification by sex-specific median height failed to show systematic differences in survival rates between short and tall participants, so results presented are not stratified by height.”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“In some subsets of slow walkers of Hispanic descent, survival rates were 10% to 20% higher than in other groups (eTable 2).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“At age 75, predicted 10-year survival across the range of gait speeds ranged from 19% to 87% in men and from 35% to 91% in women.”
§ Gait Speed and Survival in Older Adults > Abstract > Results
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“Stratification by race/ethnicity (non-Hispanic white, black, Hispanic) suggested generally similar survival rates by gait speed among age and sex groups.”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“Gait speed was associated with survival in all studies (pooled hazard ratio per 0.1 m/s, 0.88; 95% CI, 0.87–0.90; P<. 001).”
- Also stated in: § RESULTS · plain
“The overall HR for survival per each 0.1 m/s faster gait speed was 0.88 (95% CI, 0.87–0.90; P<.001) when pooled across all studies using a random-effects meta-analytic statistical approach”
- Also stated in: § Conclusion · plain
“In this pooled analysis of individual data from 9 selected cohorts, gait speed was associated with survival in older adults.”
§ Gait Speed and Survival in Older Adults > Abstract > Results
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“Gait speeds of 1.0 m/s or higher consistently demonstrated survival that was longer than expected by age and sex alone.”
§ Gait Speed and Survival in Older Adults > RESULTS
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“Gait speed added substantially37 to age and sex in 7 of the 9 studies and in the pooled analysis.”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“Gait speed, age, and sex yielded a C statistic (0.734) that was not significantly different from age, sex, mobility aids, and functional status (0.732; (P=.95; Table 3).”
§ Gait Speed and Survival in Older Adults > RESULTS
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“Three studies had sufficiently consistent data on functional status at baseline to allow pooling.”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“Although the sample size of very slow walkers was small, our data suggest that there may be a subpopulation who walk very slowly but survive for long periods.”
§ Gait Speed and Survival in Older Adults > COMMENT
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“Study follow-up time ranged from 6.0 to 21.0 years, with participants followed up for a mean of 12.2 and a median of 13.8 years.”
§ Gait Speed and Survival in Older Adults > RESULTS
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“Of the total, 59.6% were women.”
§ Gait Speed and Survival in Older Adults > RESULTS
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“Predicted years of remaining life for each sex and age increased as gait speed increased, with a gait speed of about 0.8 m/s at the median life expectancy at most ages for both sexes (Figure 2; a PDF of enlarged graphs is available at http://www.jama.com).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“Similarly, there was a wide range of gait speeds, from less than 0.4 m/s (n=1247) to more than 1.4 m/s (n=1491).”
§ Gait Speed and Survival in Older Adults > RESULTS
Strength:plain· not yet calibratedn = 1,491Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
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“In this older adult population, the relationship of gait speed with remaining years of life was consistent across age groups, but the absolute number of expected remaining years of life was larger at younger ages.”
§ Gait Speed and Survival in Older Adults > RESULTS
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“For 70-year-old men, life expectancy ranged from 7 to 23 years and for women, from 10 to 30 years.”
§ Gait Speed and Survival in Older Adults > RESULTS
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“There were substantial numbers of African American (n=3852) and Hispanic (n=2650) participants.”
§ Gait Speed and Survival in Older Adults > RESULTS
Strength:plain· not yet calibratedn = 3,852Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
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“Mortality rates appear to be related to length of follow-up (Table 1).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“Predicted survival based on age, sex, and gait speed was as accurate as predicted based on age, sex, use of mobility aids, and self-reported function or as age, sex, chronic conditions, smoking history, blood pressure, body mass index, and hospitalization.”
§ Gait Speed and Survival in Older Adults > Abstract > Results
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In the paper
“In women, the probability of 5-year survival remained greater than 0.5 until advanced age (eFigure 3B), but 10-year survival at age 75 years ranged from 0.34 to 0.92 and at age 80 years from 0.22 to 0.86 (eFigure 4B).”
§ Gait Speed and Survival in Older Adults > RESULTS
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“For the 3 levels of functional status (independent, difficulty with instrumental ADLs, and dependent in ADLs), the pooled HR per 0.1-m/s increase in gait speed for those who were independent was 0.92 (P= .005), for those with difficulty in instrumental activities was also 0.92 (P<.001) but was 0.94 (P=.02) among those dependent in ADLs.”
§ Gait Speed and Survival in Older Adults > RESULTS
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“The studies had a wide age range, including 1765 persons older than 85 years.”
§ Gait Speed and Survival in Older Adults > RESULTS
Strength:plain· not yet calibratedn = 1,765Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
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“There were consistent associations across studies, although given the large sample sizes, Q statistics were often statistically significant (details available in eFigure 1A–M available at http://www.jama.com).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“Age-adjusted HRs by study ranged from 0.83 to 0.94 and all were significant (P<.001; Figure 1).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“When dichotomized at a score of 100 into low and high activity, MrOS had consistent and statistically significant HRs for low (HR, 0.85; 95% CI, 0.81–0.88) and high (HR, 0.87; 95% CI, 0.84–0.90) physical”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“In the pooled sample, median survival in years for the age groups 65 through 74 years was 12.6 for men and 16.8 for women; for 75 through 84 years, 7.9 for men and 10.5 for women; and for 85 years or older, 4.6 for men and 6.4 years for women (eTable 3 available at http://www.jama.com).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“Gait speed was associated with differences in the probability of survival at all ages in both sexes, but was especially informative after age 75 years.”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“There were 17 528 deaths; the overall 5-year survival rate was 84.8% (confidence interval [CI], 79.6%–88.8%)and 10-year survival rate was 59.7% (95%CI, 46.5%–70.6%).”
§ Gait Speed and Survival in Older Adults > Abstract > Results
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In the paper
“Further adjustment for sex, BMI, smoking status, systolic blood pressure, diseases, prior hospitalization, and self-reported health did not change the results (overall HR, 0.90; 95% CI, 0.89–0.91; P<.001).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“In men, the probability of 5-year survival at age 85 ranged from 0.3 to 0.88 (eFigure 3A) and the probability of 10-year survival at age 75 years ranged from 0.18 to 0.86 (eFigure 4A).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“Survival increased across the full range of gait speeds, with significant increments per 0.1 m/s.”
§ Gait Speed and Survival in Older Adults > Abstract > Results
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In the paper
“The 9 participating studies contributed a total of 34 485 participants (Table 1).”
§ Gait Speed and Survival in Older Adults > RESULTS
Strength:plain· not yet calibratedn = 34,485Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
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In the paper
“There were 17 528 total deaths across all studies, with rates varying from 18.40% to 91.87% in individual studies.”
§ Gait Speed and Survival in Older Adults > RESULTS
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
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In the paper
“In the Hispanic EPESE, the HR for low physical activity was significant (0.92; 95% CI, 0.88–0.96) but the HR for higher physical activity was not (0.99; 95% CI, 0.95–1.04).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“Pooled HRs for all subgroups except functional status were consistently in the range of 0.81 to 0.92 and all were significant (P<.002).”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“C statistics for age, sex, and gait speed were greater than those for age, sex, and chronic diseases in 4 of 9 studies, approximately equivalent in 5 studies and inferior in no studies.”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“For 10-year survival, 6 studies had sufficient follow-up time to perform many of the analyses (Table 3).”
§ Gait Speed and Survival in Older Adults > RESULTS
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
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In the paper
“We assessed usual vs fast gait speed in the single study with both measures (Invecciare in Chianti18 study: usual, 0.727 [95% CI, 0.678–0.776]; fast, 0.684 [95% CI, 0.630–0.739]), suggesting that fast walks did not have an advantage in survival prediction over usual-paced walks.”
§ Gait Speed and Survival in Older Adults > RESULTS
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
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In the paper
“For these studies, gait speed, age, and sex yielded a C statistic (0.741) that was not significantly different (P=.78) from age, sex, mobility aids, and functional status (P=.75; Table 3).”
§ Gait Speed and Survival in Older Adults > RESULTS
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
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In the paper
“Gait speed added predictive ability to age and sex in 4 of 6 studies and in the pooled analysis.”
§ Gait Speed and Survival in Older Adults > RESULTS
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In the paper
“In our data, predicted life expectancy at the median for age and sex occurs at about 0.8 m/s; faster gait speeds predict life expectancy beyond the median.”
§ Gait Speed and Survival in Older Adults > COMMENT
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In the paper
“Gait speed has been recommended as a potentially useful clinical indicator of well-being among the older adults.14”
§ Gait Speed and Survival in Older Adults > Abstract > Conclusion
What the sources say
- Not matchedcites [14]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:hedged· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it.
- Not matched
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In the paper
“Because physical activity measures were not sufficiently consistent across studies, effects could not be pooled.”
§ Gait Speed and Survival in Older Adults > RESULTS
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
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In the paper
“Gait speed could be considered a simple and accessible summary indicator of vitality because it integrates known and unrecognized disturbances in multiple organ systems, many of which affect survival.”
§ Gait Speed and Survival in Older Adults > COMMENT
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“Only a few models assess overall predictive capacity using C statistics; the reported values are in the range found in the present study (published area under the curve range, 0.66–0.8261 vs this study, 0.717 and 0.737).”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [61]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Not matched
In the paper
“Because gait speed can be assessed by nonprofessional staff using a 4-m walkway and a stopwatch,21 it is relatively simple to measure compared with many medical assessments.”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [21]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Not matched
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In the paper
“Several authors have proposed that gait speeds faster than 1.0 m/s suggest healthier aging while gait speeds slower than 0.6 m/s increase the likelihood of poor health and function.7,21”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [7]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [21]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:hedged· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Not matched
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In the paper
“The participating study cohorts, while large and diverse, do not represent the universe of possible data.”
§ Gait Speed and Survival in Older Adults > COMMENT
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
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In the paper
“The strengths of this study are the very large sample of individual participant data from multiple diverse populations of community-dwelling elders who were followed up for many years and use of consistent measures of performance and outcome.”
§ Gait Speed and Survival in Older Adults > COMMENT
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Gait speed might help refine survival estimates in clinical practice or research because it is simple and informative.”
§ Gait Speed and Survival in Older Adults > COMMENT
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although the gait speed–survival relationship seems continuous across the entire range, cut points may help interpretation.”
§ Gait Speed and Survival in Older Adults > COMMENT
Strength:hedged· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
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In the paper
“Also, participants in these studies had no prior knowledge about the meaning of walking speed.”
§ Gait Speed and Survival in Older Adults > COMMENT
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✗ Based: failsProbably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“Slowing gait may reflect both damaged systems and a high-energy cost of walking.13,39–54”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [13]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [39]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [40]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [41]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [42]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [43]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [44]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [45]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [46]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [47]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Not matched
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Gait speed, age, and sex may offer the clinician tools for assessing expected survival to contribute to tailoring goals of care in older adults.”
§ Gait Speed and Survival in Older Adults > COMMENT
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We were unable to assess the association of physical activity with survival in pooled analyses because measures of activity were highly variable across studies.”
§ Gait Speed and Survival in Older Adults > COMMENT
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“However, median years of survival in this study resemble estimates for US adults across the sex and age range assessed.62”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [62]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Only 1 of the 9 studies was based in clinical practice,21 and advanced dementia is rare in populations who are competent to consent for research.”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [21]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Not matched
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“Prior analyses used single cohorts and presented results as relative rather than absolute risk, as done herein.”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [6]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [7]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [9]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [10]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [11]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [12]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [55]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [56]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
- Not matched
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“Some models use self-reported information but others also include physiological or performance data, for a total of 4 to more than 10 predictive factors.”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [3]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [4]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [5]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [57]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [58]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [59]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [60]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This study has the limitations of observational research; it cannot establish causal relationships and is vulnerable to various forms of healthy volunteer bias.”
§ Gait Speed and Survival in Older Adults > COMMENT
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The research studies analyzed herein used trained staff to measure gait speed. Staffin clinical settings would need initial training and may produce more variable results.”
§ Gait Speed and Survival in Older Adults > COMMENT
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Others propose one cutoff around 0.8 m/s.13”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [13]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:plain· not yet calibratedTests✗ Asserted: fails✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The authors may not put it forward as true. The paper’s conclusions may not depend on it.
- Not matched
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“Long-distance walks have become accepted in some medical fields and may contribute information beyond short walks.66–68”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [66]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [67]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [68]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Not matched
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The results found herein suggest that gait speed appears to be especially informative in older persons who report either no function all imitations or only difficulty with instrumental ADLs and may be less helpful for older adults who already report dependence in basic ADLs.”
§ Gait Speed and Survival in Older Adults > COMMENT
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“Similarly, mortality prediction models have been developed.3–5,57–60”
§ Gait Speed and Survival in Older Adults > COMMENT
What the sources say
- Not matchedcites [3]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [4]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [5]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [57]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [58]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [59]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [60]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, the longer distance and time to perform the test may limit feasibility in many clinical settings.”
§ Gait Speed and Survival in Older Adults > COMMENT
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
There are currently no well-established approaches to predicting life expectancy that incorporate health and function.
“There are currently no well-established approaches to predicting life expectancy that incorporate health and function, although several models have been developed from individual data sources.3–5”
The paper relies on this without support.
Survival estimates help individualize goals of care for geriatric patients.
“Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival.”
The paper relies on this without support.
Advanced dementia is rare in populations who are competent to consent for research.
“Only 1 of the 9 studies was based in clinical practice,21 and advanced dementia is rare in populations who are competent to consent for research.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The Edmonton Frail Scale is a multi-dimensional assessment instrument that includes the TUGT, and a test for cognitive impairment (108). It is quick to administer (less than 5 minutes) and is valid, reliable and feasible for routine use by non-geriatricians”
From Frailty in elderly people (2013) · cites this paper as [108]
In the citing paper
“Moreover, gait speed was associated with survival in pooled analysis of individual data from 9 cohort studies (pooled HR per 0.1 m/s: 0.88, 95% CI: 0.87–0.90, P < 0.001) (78).”
From Health Consequences of Sarcopenic Obesity: A Narrative Review (2020) · cites this paper as [78]
In the citing paper
“including a significant association with survival at increments of 0.1 m/s.84”
In the citing paper
“accumulating evidence from both preclinical studies and recent human clinical trials strongly suggests that Mt have a key role in the pathogenesis of age-related functional decline, marked by slower walking speed.(Hiona and Leeuwenburgh 2008;Studenski, Perera, Patel, Rosano, Faulkner, Inzitari, Brach, Chandler, Cawthon, Connor, Nevitt, Visser, Kritchevsky, Badinelli, Harris, Newman, Cauley, Ferru”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Studenski et al. 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
SPPB estimate falls outside its confidence interval
MinorThe reported SPPB C statistic is 0.738, above the upper limit of its reported 95% confidence interval, 0.735.
“SPPB, 0.738”
“95% CI, 0.690–0.735”
Conflicting 10-year survival ranges at age 75
MinorThe abstract gives age-75 survival ranges of 19%-87% for men and 35%-91% for women. The results give 18%-86% and 34%-92%, respectively, for the same predicted outcome.
“At age 75, predicted 10-year survival across the range of gait speeds ranged from 19% to 87% in men and from 35% to 91% in women.”
“In men, the probability of 5-year survival at age 85 ranged from 0.3 to 0.88 (eFigure 3A) and the probability of 10-year survival at age 75 years ranged from 0.18 to 0.86 (eFigure 4A). In women, the probability of 5-year survival remained greater than 0.5 until advanced age (eFigure 3B), but 10-year survival at age 75 years ranged from 0.34 to 0.92”
Citations
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InfluentialQuantifying heterogeneity in a meta‐analysis
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The physical activity scale for the elderly (PASE): Development and evaluation
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Items 301–400 of 4,516
Lum, H. D., Studenski, S. A., Degenholtz, H. B., & Hardy, S. E. (2012) · Journal of General Internal Medicine · doi:10.1007/s11606-012-2116-3 · Cited by 128
Self-citationSorond, F. A., Cruz‐Almeida, Y., Clark, D. J., Viswanathan, A., Scherzer, C. R., Jager, P. L. D., Csiszár, A., Laurienti, P. J., Hausdorff, J. M., Chen, W., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv130 · Cited by 125
Self-citationThe neural correlates of discrete gait characteristics in ageing: A structured review
Wilson, J., Allcock, L. M., Ardle, R. M., Taylor, J., & Rochester, L. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.017 · Cited by 128
Beaudart, C., Alcázar, J., Aprahamian, I., Batsis, J. A., Yamada, Y., Prado, C. M. M., Reginster, J., Sánchez‐Rodríguez, D., Lim, W. S., Sim, M., et al. (2025) · Aging Clinical and Experimental Research · doi:10.1007/s40520-025-02995-9 · Cited by 160
Health and Aging: Development of The Irish Longitudinal Study on Ageing Health Assessment
Cronin, H., O’Regan, C. M., Finucane, C., Kearney, P. M., & Kenny, R. A. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12197 · Cited by 119
Prostate Cancer in Elderly Men
Roussel, B. N., Ouellet, G. M., Mohile, S. G., & Dale, W. (2015) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2015.07.004 · Cited by 122
Kaye, J. A., Mattek, N., Dodge, H. H., Buracchio, T., Austin, D., Hagler, S., Pavel, M., & Hayes, T. L. (2011) · Gait & Posture · doi:10.1016/j.gaitpost.2011.09.006 · Cited by 120
Ancum, J. M. V., van Schooten, K. S., Jonkman, N. H., Huijben, B., van Lummel, R. C., Meskers, C. G. M., Maier, A. B., & Pijnappels, M. A. G. M. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.12.008 · Cited by 128
“Gait speed is regarded an important clinical measure because of its predictive ability of impending disability, morbidity and mortality [1,2] and is often referred to as the sixth vital sign [3].”
BackgroundAli, N., Tian, H., Thabane, L., Ma, J., Wu, H., Zhong, Q., Gao, Y., Sun, C., Zhu, Y., & Wang, T. (2022) · The journal of prevention of Alzheimer's disease · doi:10.14283/jpad.2022.16 · Cited by 121
“It is believed that slow gait speed is the early sign of cognitive decline and an indicator of shorter life expectancy (14).”
BackgroundMirelman, A., Shema, S., Maidan, I., & Hausdorff, J. M. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63916-5.00007-0 · Cited by 147
Extracting Gait Velocity and Stride Length from Surrounding Radio Signals
Hsu, C.-Y., Liu, Y., Kabelac, Z., et al. (2017) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3025453.3025937 · Cited by 120
Metabolomic Analysis of Skeletal Muscle in Aged Mice
Uchitomi, R., Hatazawa, Y., Senoo, N., Yoshioka, K., Fujita, M., Shimizu, T., Miura, S., Ono, Y., & Kamei, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-46929-8 · Cited by 119
Technical validation of real-world monitoring of gait: a multicentric observational study
Mazzà, C., Alcock, L., Aminian, K., Becker, C., Bertuletti, S., Bonci, T., Brown, P. M., Brozgol, M., Buckley, E. E., Carsin, A., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-050785 · Cited by 119
Demakakos, P., Cooper, R., Hamer, M., de Oliveira, C. M., Hardy, R., & Breeze, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068632 · Cited by 122
Reference values for standardized tests of walking speed and distance: A systematic review
Salbach, N. M., O’Brien, K. K., Brooks, D., Irvin, E., Martino, R., Takhar, P., Chan, S., & Howe, J.-A. (2014) · Gait & Posture · doi:10.1016/j.gaitpost.2014.10.002 · Cited by 117
The 4-metre gait speed in COPD: responsiveness and minimal clinically important difference
Kon, S. S. C., Canavan, J. L., Nolan, C. M., Clark, A. L., Jones, S. E., Cullinan, P., Polkey, M. I., & Man, W. D. (2013) · European Respiratory Journal · doi:10.1183/09031936.00088113 · Cited by 118
Skloot, G. S., Busse, P. J., Braman, S. S., Kovacs, E. J., Dixon, A. E., Fragoso, C. A. V., Scichilone, N., Prakash, Y. S., Pabelick, C. M., Mathur, S. K., et al. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201608-658st · Cited by 118
Monfort, S. M., Pan, X. J., Patrick, R., Ramaswamy, B., Wesolowski, R., Naughton, M. J., Loprinzi, C. L., Chaudhari, A. M. W., & Lustberg, M. B. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4230-8 · Cited by 120
“The decrease in walking speed associated with taxane therapy in this study appears to be clinically meaningful when considering the significance of similar decreases with respect to survival rate and falls in previous studies on the elderly [23, 34].”
ResultAccelerometry Data in Health Research: Challenges and Opportunities
Karas, M., Bai, J., Strączkiewicz, M., Harezlak, J., Glynn, N. W., Harris, T. B., Zipunnikov, V., Crainiceanu, C. M., & Urbanek, J. K. (2019) · Statistics in Biosciences · doi:10.1007/s12561-018-9227-2 · Cited by 120
Shahar, D. R., Houston, D. K., Hue, T. F., Lee, J., Sahyoun, N. R., Tylavsky, F. A., Geva, D., Vardi, H., & Harris, T. B. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04167.x · Cited by 121
Hurria, A., Browner, I. S., Cohen, H. J., Denlinger, C. S., deShazo, M., Extermann, M., Ganti, A. K., Holland, J. C., Holmes, H. M., Karlekar, M. B., et al. (2012) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2012.0019 · Cited by 115
An overview of frailty in kidney transplantation: measurement, management and future considerations
Harhay, M. N., Rao, M. K., Woodside, K. J., Johansen, K. L., Lentine, K. L., Tullius, S. G., Parsons, R. F., Alhamad, T., Berger, J., Cheng, X. S., et al. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa016 · Cited by 119
“Gait speed [49] Timed walking over a short distance Does not include”
BackgroundBoyer, K. A., Hayes, K. L., Umberger, B. R., Adamczyk, P. G., Bean, J. F., Brach, J. S., Clark, B. C., Clark, D. J., Ferrucci, L., Finley, J. M., et al. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112102 · Cited by 116
“In old age, reduced or limited mobility, defined here as the ability to move freely in the environment, is associated with a loss of independence and an increased risk of morbidity and mortality [1-4].”
BackgroundLight-Intensity Activity Attenuates Functional Decline in Older Cancer Survivors
Blair, C. K., Morey, M. C., Desmond, R. A., Cohen, H. J., Sloane, R. J., Snyder, D. C., & Demark‐Wahnefried, W. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000241 · Cited by 125
Bridenbaugh, S. A., & Kressig, R. W. (2015) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-014-0845-0 · Cited by 116
Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia
Reginster, J.-Y., Cooper, C., Rizzoli, R., Kanis, J. A., Appelboom, G., Bautmans, I., Bischoff-Ferrari, H. A., Boers, M., Brandi, M. L., Bruyère, O., et al. (2016) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0517-y · Cited by 112
Batsis, J. A., Sahakyan, K., Rodríguez-Escudero, J. P., Bartels, S. J., Somers, V. K., & López-Jiménez, F. A. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.07.014 · Cited by 116
An overview of vestibular rehabilitation
Whitney, S. L., Alghwiri, A. A., & Alghadir, A. H. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63437-5.00013-3 · Cited by 118
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“adults [51, 52], micro gait characteristics offer a more focused examination to differentiate pathology”
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BackgroundEffect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility
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“Slow gait speed in older adults is associated with an increased risk for disability,(1,2) institutionalization(1) and mortality.(1,3) Poor muscle function (strength/power) is an important risk factor for slowed gait and is also associated with increased risk of disability and death.”
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Metadata
- Authors
- Studenski, S.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Studenski, Stephanie
- ORCID
- Studenski, Stephanie
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2011-01-05
- Volume
- 305
- Issue
- 1
- Pages
- 50
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC3080184
- OpenAlex
- W2159296038
- Semantic Scholar
- 25de2f67035336224c9f1e37f58c5b531d34b9ed
- Cited by
- 4,558
- References
- 73
- Citations by year
- 2026: 377 · 2025: 333 · 2024: 267 · 2023: 311 · 2022: 355 · 2021: 399 · 2020: 389 · 2019: 358 · 2018: 272 · 2017: 301 · 2016: 255 · 2015: 273 · 2014: 243 · 2013: 184 · 2012: 166
- FWCI
- 100.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- National Institute on Aging (AG023641, AG 024827, K07AG023641, P30AG024827, P30AG021332)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- walking speed, survival, older adults, life expectancy, physical performance, mortality prediction, goals of care, community-dwelling older adults
- MeSH terms
- Aged, Female, Gait, Humans, Life Expectancy, Male, United States, Cohort Studies, Geriatric Assessment, Survival Analysis
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