Cited by 131Nutrition and Health in AgingClinical Nutrition and GastroenterologyDialysis and Renal Disease Management

Malnutrition in Adults

Cederholm, Tommy, Bosaeus, Ingvar·2024·New England Journal of Medicine

Abstract

Malnutrition occurs in up to 10% of community-dwelling older people and contributes to morbidity and mortality. The two main pathologic pathways are nutrient deprivation and inflammation-induced tissue catabolism with anorexia.

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Crossref · 10.1056/nejmra2212159

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75 of 75 references verified0 citation errors · 0 not checkable

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  • SO might be influenced by multiple shared factors and pathophysiological pathways that affect both sarcopenia and obesity, including age, sedentary lifestyle, lack of muscle exercise, hormone levels, nutritional status, insulin resistance, systemic inflammation and others.

    “SO might be influenced by multiple shared factors and pathophysiological pathways that affect both sarcopenia and obesity, including age, sedentary lifestyle, lack of muscle exercise, hormone levels, nutritional status, insulin resistance, systemic inflammation and others [14, 23, 24, 25, 26, 27].”
  • Recent recommendations of protein requirements in healthy adults, considering age-related changes in metabolism, immunity, hormone synthesis, kidney function and progressive frailty, suggest a range of 0.8-1.2 g/kg per day.

    “Recent recommendations of protein requirements in healthy adults, considering age‐related changes in metabolism, immunity, hormone synthesis, kidney function and progressive frailty, suggest a range of 0.8–1.2 g/kg per day [25].”
  • After approximately 24-48 hours of fasting, hepatic glycogen and skeletal muscle glycogen reservoirs become depleted.

    “After ~24-48 h of fasting, these reservoirs become depleted [9].”

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Authors
Cederholm, T., & Bosaeus, I.
Affiliations
Uppsala University (SE)
Venue
New England Journal of Medicine
Published
2024-07-11
Volume
391
Issue
2
Pages
155-165
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W4400483843
Cited by
131
References
75
Citations by year
2026: 67 · 2025: 48 · 2024: 15 · 2023: 1
FWCI
7.39
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
malnutrition, older adults, community-dwelling older adults, nutrient deprivation, inflammation, tissue catabolism, anorexia, morbidity, mortality
MeSH terms
Adult, Humans, Nutrition Assessment, Malnutrition

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