Cited by 193Lipoproteins and Cardiovascular HealthDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Statins for the prevention of dementia

McGuinness, Bernadette, Craig, David, Bullock, Roger, Passmore, Peter·2009·Cochrane Database of Systematic Reviews

Abstract

Background This is an update of a Cochrane review first published in 2001. At that stage there was insufficient evidence to recommend statins for the prevention of Alzheimer's disease (AD). The scope of this review has been expanded to include all forms of dementia. Objectives To assess the effects of statins in the prevention of dementia. Search strategy The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group, The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL and LILACS were searched on 10 October 2007 using the terms statin*, lovastatin*, pravastatin*, simvastatin*, fluvastatin*, atorvastatin* and rosuvastatin*. The CDCIG Register contains records from many healthcare databases, SIGLE, LILACS as well as many trials databases and is updated regularly. Selection criteria Double-blind randomized placebo-controlled trials of statins in people at risk of AD and dementia. Data collection and analysis Two independent reviewers extracted and assessed data independently and agreement was reached after discussion. Adverse effects were noted. Main results Two trials were identified with 26,340 participants; HPS 2002 and PROSPER 2002. Age range was 40-82 years across the two studies, PROSPER 2002 included 5804 patients aged 70-82 years and HPS included 20,536 patients with 5806 at least 70 years old at study entry. Mean total cholesterol 5.9 mmol/l, LDL cholesterol 3.4 mmol/l at study entry with mean reduction in LDL cholesterol of 1.0 mmol/l in simvasta…

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Crossref · 10.1002/14651858.cd003160.pub2

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Authors
McGuinness, B., Craig, D., Bullock, R., & Passmore, P.
Affiliations
  • Queen's University Belfast (GB)
  • Victoria Hospital (CA)
Venue
Cochrane Database of Systematic Reviews
Published
2009-04-15
Issue
2
Pages
CD003160-CD003160
ISSN
1361-6137 (ISSN-L)
OpenAlex
W4210956788
Cited by
193
References
105
Citations by year
2025: 3 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 9 · 2016: 17 · 2015: 18 · 2014: 17 · 2013: 18 · 2012: 22
Type
reference entry
Language
en
Open access
closed
Locations
  • Cochrane Database of Systematic Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (Queen's University Belfast) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
statins, dementia prevention, Alzheimer's disease, simvastatin, pravastatin, cognitive function, LDL cholesterol lowering, adverse effects, statin safety, older adults, hypercholesterolemia, dementia incidence, cholesterol-lowering drugs
MeSH terms
Alzheimer Disease, Anticholesteremic Agents, Cognition, Dementia, Humans, Randomized Controlled Trials as Topic, Pravastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin

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