Statins for the prevention of dementia
Abstract
Background This is an update of a Cochrane review first published in 2001. At that stage there was insufficient evidence to recommend statins for the prevention of Alzheimer's disease (AD). The scope of this review has been expanded to include all forms of dementia. Objectives To assess the effects of statins in the prevention of dementia. Search strategy The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group, The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL and LILACS were searched on 10 October 2007 using the terms statin*, lovastatin*, pravastatin*, simvastatin*, fluvastatin*, atorvastatin* and rosuvastatin*. The CDCIG Register contains records from many healthcare databases, SIGLE, LILACS as well as many trials databases and is updated regularly. Selection criteria Double-blind randomized placebo-controlled trials of statins in people at risk of AD and dementia. Data collection and analysis Two independent reviewers extracted and assessed data independently and agreement was reached after discussion. Adverse effects were noted. Main results Two trials were identified with 26,340 participants; HPS 2002 and PROSPER 2002. Age range was 40-82 years across the two studies, PROSPER 2002 included 5804 patients aged 70-82 years and HPS included 20,536 patients with 5806 at least 70 years old at study entry. Mean total cholesterol 5.9 mmol/l, LDL cholesterol 3.4 mmol/l at study entry with mean reduction in LDL cholesterol of 1.0 mmol/l in simvasta…
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Some observational studies suggest aspirin benefits cognition, while others do not confirm this.
“Some observational studies have suggested a beneficial effect of aspirin on cognition,465,466 although this was not confirmed in others.467,468”
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Ganguli, M., & Kukull, W. A. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.311 · Cited by 28 · see citing works
Cooper, S., Ademola, T., CASLAKE, M. J., Douglas, E. A., Evans, J. J., Greenlaw, N., Haig, C. E., Hassiotis, A., Jahoda, A. J., McConnachie, A., et al. (2016) · Trials · doi:10.1186/s13063-016-1370-9 · Cited by 27 · see citing works
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Cheng, P., Sy, H., Wu, S., Wang, W., & Chen, Y. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.06.003 · Cited by 25 · see citing works
Hypercholesterolemia and the Increased Risk of Vascular Dementia: a Cholesterol Perspective
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- Authors
- McGuinness, B., Craig, D., Bullock, R., & Passmore, P.
- Affiliations
- Queen's University Belfast (GB)
- Victoria Hospital (CA)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- John Wiley & Sons, Ltd
- Published
- 2009-04-15
- Issue
- 2
- Pages
- CD003160-CD003160
- ISSN
- 1361-6137 (ISSN-L)
- OpenAlex
- W4210956788
- Cited by
- 193
- References
- 105
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 9 · 2016: 17 · 2015: 18 · 2014: 17 · 2013: 18 · 2012: 22
- Type
- reference entry
- Language
- en
- Update notices
- new_version (2016-01-04)
- Open access
- closed
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- statins, dementia prevention, Alzheimer's disease, simvastatin, pravastatin, cognitive function, LDL cholesterol lowering, adverse effects, statin safety, older adults, hypercholesterolemia, dementia incidence, cholesterol-lowering drugs
- MeSH terms
- Alzheimer Disease, Anticholesteremic Agents, Cognition, Dementia, Humans, Randomized Controlled Trials as Topic, Pravastatin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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