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Psychological interventions for treatment of inflammatory bowel disease
Abstract
BACKGROUND: The effect of psychological interventions in inflammatory bowel diseases (IBD) is controversial. OBJECTIVES: To assess the effects of psychological interventions (psychotherapy, patient education, relaxation techniques) on health related quality of life, coping, emotional state and disease activity in IBD. SEARCH STRATEGY: We searched the specialized register of the IBD/FBD Group, CENTRAL (Issue 5, 2010) and from inception to April 2010: Medline, Embase, LILACS, Psyndex, CINAHL, PsyInfo, CCMed, SOMED and Social SciSearch. Conference abstracts and reference lists were also checked. SELECTION CRITERIA: Randomized, quasi-randomized and non randomized controlled trials of psychological interventions in children or adults with IBD with a minimum follow up time of 2 months. DATA COLLECTION AND ANALYSIS: Data were extracted and study quality was independently assessed by two raters. Pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated using a random effects model. MAIN RESULTS: Twenty-one studies were eligible for inclusion (1745 participants, 8 RCT, 4 QRCT, 8 NRCT; 19 in adults, 2 in adolescents). Most studies used multimodular approaches. The risk of bias was high for all studies.In adults, psychotherapy had no effect on quality of life at around 12 months (3 studies, 235 patients, SMD -0.07; 95% CI -0.33 to 0.19), emotional status (depression, 4 studies, 266 patients, SMD 0.03; 95% CI -0.22 to 0.27) or proportion of patients not in remission (5 studies, 287 patients, OR 0.85; 95% CI 0.48 to 1.48). Results were similar at 3 to 8 months. There was no evidence for statistical heterogeneity or subgroup effects based on type of disease or intensity of the therapy. In adolescents, there were positive short term effects of psychotherapy on most outcomes assessed including quality of life (2 studies, 71 patients, SMD 0.70; 95% CI 0.21 to 1.18) and depression (1 study, 41 patients, SMD -0.62; 95% CI -1.25 to 0.01).Educational interventions were ineffective with respect to quality of life at 12 months (5 studies, 947 patients, SMD 0.11; 95% CI -0.02 to 0.24), depression (3 studies, 378 patients, SMD -0.08; 95% CI -0.29 to 0.12) and proportion of patients not in remission (3 studies, 434 patients, OR 1.00; 95% CI 0.65 to 1.53). AUTHORS' CONCLUSIONS: There is no evidence for efficacy of psychological therapy in adult patients with IBD in general. In adolescents, psychological interventions may be beneficial, but the evidence is limited. Further evidence is needed to assess the efficacy of these therapies in subgroups identified as being in need of psychological interventions, and to identify what type of therapy maybe most useful.
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“Many studies are observed to be non-randomized, devoid of inclusion and exclusion criteria, neglect to report salient participant data (e.g., IBD type), and neglect to report sufficient intervention program detail [18,19,20,21].”
In the citing paper
“However, the findings of Gracie et al. and Knowles et al. contrast somewhat with those of earlier reviews, which observed minimal-to-no effectiveness of psychotherapeutic interventions in intervening with depression, quality of life (QoL), coping, and anxiety [20,21].”
In the citing paper
“whereas previously no efficacy was reported in a review of psychological interventions for adults with IBD 38 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [38]
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ResultManagement of Paediatric Ulcerative Colitis, Part 1
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BackgroundGracie, D. J., Irvine, A. J., Sood, R., Mikocka-Walus, A., Hamlin, P. J., & Ford, A. C. (2017) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30206-0 · Cited by 271
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“Bioinformatics analysis of genes that changed expression (by using Interactive network analysis) found that NF-κB is a key molecule for both IBS and IBD.”
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“Estimated 10-yr survival (%) (Median [range]) 98 [53-98] 98 [21-98] 98 [98-98] <0.”
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MethodO'Connor, M., Bager, P., Duncan, J., Gaarenstroom, J., Younge, L., Détré, P., Bredin, F., Dibley, L. B., Dignass, A. U., Barrero, M. G., et al. (2013) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2013.06.004 · Cited by 150
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Bennebroek Evertsz', F., Thijssens, N. A. M., Stokkers, P. C. F., Grootenhuis, M. A., Bockting, C. L. H., Nieuwkerk, P. T., & Sprangers, M. A. G. (2012) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2011.07.006 · Cited by 131
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“Pan-colitis 17% (4) 10% (2) Crohn's disease 27% (9) 36% (12) Ileal 22% (2) 33% (4)”
Psychiatric co‐morbidity is associated with increased risk of surgery in Crohn's disease
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“However, a Cochrane review found no benefit of psychological interventions on IBD [53].”
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Selinger, C. P., & Bannaga, A. (2015) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s57982 · Cited by 109
“A recent Cochrane review summarized the evidence for general adult IBD patients and found no effect of psychotherapy on quality of life, depressive symptoms, or clinical remission from IBD.(61) While there is conclusive evidence for the effectiveness of psychological therapies and the use of pharmacological agents for…”
InfluentialPsychotherapy for inflammatory bowel disease: a review and update
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Systematic review: interventions for abdominal pain management in inflammatory bowel disease
Norton, C. S., Czuber‐Dochan, W., Artom, M., Sweeney, L., & Hart, A. L. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14108 · Cited by 110
Knowles, S. R., Monshat, K., & Castle, D. J. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e318296ae5a · Cited by 102
“Several reviews of psychological interventions in IBD have been undertaken.(16,33,51,52) Reviewing 4 self-management/patient education and 10 psychotherapy studies (i.”
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“92 (chi-square) CD 13 (42%) 27 (41%) Disease Location UC (n = 57) Proctitis 6 (33%) 7 (18%) N/A‡ Left-Sided 7 (39%) 21 (54%) Pan-Colitis 5 (28%) 11 (28%) CD (n = 40) Ileal 5 (38%) 7 (26%) N/A‡ Colonic 3 (23%) 10 (37%) Ileo-colonic 5 (38%) 10 (37%) Median disease duration, years (range) 9 (1-36) 8 (1-47) 0.”
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Click, B. H., Rivers, C. R., Κoutroubakis, I. E., Babichenko, D., Anderson, A. J. M., Hashash, J. G., Dunn, M. A., Schwartz, M. B., Swoger, J. M., Baidoo, L., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000763 · Cited by 95
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McCombie, A., Mulder, R., & Gearry, R. B. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2012.05.021 · Cited by 89
Schoultz, M., Atherton, I., & Watson, A. J. M. (2015) · Trials · doi:10.1186/s13063-015-0909-5 · Cited by 92
“In summary, while high dropout rates are a recognised occurrence in psychological intervention trials [69–71], the demand for psychological interventions in IBD is pertinent, and judging from those that attended the intervention, it appears that careful patient selection remains essential [72, 73].”
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“In recent years, several reviews have been published on the efficacy of psychotherapy for QoL, emotional status and remission/flare status in IBD [7-10].”
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Wright, E. K., & Kamm, M. A. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000271 · Cited by 83
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“Our findings partially contrast the reported mixed effects in aforementioned systematic reviews on the effect of psychotherapy on IBD patients (Knowles et al., 2013; McCombie et al., 2013; Timmer et al., 2011).”
BackgroundResultKuo, B., Bhasin, M., Jacquart, J., Scult, M. A., Slipp, L. E., Riklin, E. I. K., Lepoutre, V., Comosa, N., Norton, B.-A., Dassatti, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123861 · Cited by 85
“, 3-months) [12]; however, the durability of these interventions was less clear [13].”
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Neilson, K., Ftanou, M., Monshat, K., Salzberg, M., Bell, S., Kamm, M. A., Connell, W., Knowles, S. R., Sevar, K., Mancuso, S. G., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000629 · Cited by 80
The psychology of wound healing
Broadbent, E., & Koschwanez, H. E. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32834e1424 · Cited by 81
“The number of recently published reviews that cover psychological influences on inflammation and wound healing [1– 13], postsurgical recovery [14] and psychological interventions developed to improve healing [15,16] is an indication of increasing recognition of this work and rapidly developing field.”
BackgroundMikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. M. (2017) · International Journal of Behavioral Medicine · doi:10.1007/s12529-016-9580-9 · Cited by 78
“Finally, the present trial leans towards the recommendations of the Cochrane review [13] in that psychotherapy does not appear to benefit all IBD patients, and subgroups in need of such an intervention may in fact benefit more than unselected IBD patients.”
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Influence of Environmental Factors in the Development and Outcomes of Inflammatory Bowel Disease.
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“48) [82].”
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Disease impact on the quality of life of children with inflammatory bowel disease
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“Further work identifying the psychological factors that influence adjustment outcomes is warranted in order to identify sub groups of patients most likely to benefit from targeted psychological therapy (Timmer et al, 2011).”
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“This was confirmed by a 2011 Cochrane review.(27) There is mounting evidence suggesting that appropriate treatment of the IBD process may reduce DS and improve health related quality of life scores.”
Psychosocial interventions for adults with newly diagnosed chronic disease: A systematic review
Akyirem, S., Forbes, A., Wad, J. L., & Due-Christensen, M. (2022) · Journal of Health Psychology · doi:10.1177/1359105321995916 · Cited by 60
“Although interventions exist to support IBD patients, such interventions target patients with longer disease duration (>3 years) (Timmer et al., 2008).”
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“[12] Clinical studies for psychological interventions have recently been conducted, but antidepressants have not been studied in the IBD patients widely.[21] Some studies have suggested that treating patients with antidepressants might be of utility to control disease severity, increase QOL and lengthen remission; but…”
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Flik, C. E., Bakker, L., Laan, W., van Rood, Y. R., Smout, A. J. P. M., & de Wit, N. J. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i12.2223 · Cited by 56
Chronic pain in patients with inflammatory bowel disease
Bakshi, N., Hart, A. L., Lee, M., Williams, A. C. D. C., Lackner, J. M., Norton, C. S., & Croft, P. R. (2021) · Pain · doi:10.1097/j.pain.0000000000002304 · Cited by 57
“IBD is an independent risk factor for becoming a heavy opioid user,88 and risk increases with psychiatric comorbidity such as depression or anxiety.37 Research continues into whether currently available opioids can be delivered, or new opioids developed, with radically less potential for addiction and serious side eff…”
BackgroundInfluentialHanlon, I., Hewitt, C. E., Bell, K. J., Phillips, A., & Mikocka‐Walus, A. A. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14840 · Cited by 50
“Regarding disease activity in IBD, there was no evidence that online CBT affected this outcome, which is consistent with other systematic reviews.(51,52) The studies included in our review recruited unselected patients with IBD, however, one of these trials(49) also conducted a post-hoc analysis on a subpopulation of…”
ResultBrooks, A. J., Norman, P., Peach, E. J., Ryder, A., Scott, A. J., Narula, P., Corfe, B. M., Lobo, A., & Rowse, G. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz028 · Cited by 49
Psychological factors associated with inflammatory bowel disease
Eugenicos, M. P., & Ferreira, N. B. (2021) · British Medical Bulletin · doi:10.1093/bmb/ldab010 · Cited by 53
“The role of psychotherapeutic interventions in IBD remains controversial.(14) Thus, the aim of this review was to identify recent studies that emerged in the ‘new biological era’, highlight and critique the current approach to managing IBD in 2020.”
ResultInterventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease
Sinopoulou, V., Gordon, M. A., Akobeng, A. K., Gasparetto, M., Sammaan, M., Vasiliou, J., & Dovey, T. M. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013531.pub2 · Cited by 50
The effect of psychotherapy on quality of life in IBD Patients: A systematic review
Paulides, E., Boukema, I., van der Woude, C. J., & de Boer, N. K. H. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa144 · Cited by 47
Practical Guideline for Fatigue Management in Inflammatory Bowel Disease
Kreijne, J. E., Lie, M. R. K. L., Vogelaar, L., & van der Woude, C. J. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv168 · Cited by 48
Kalafateli, M., Triantos, C. K., Theocharis, G. J., Giannakopoulou, D., Koutroumpakis, E., Chronis, A., Sapountzis, A., Margaritis, V., Thomopoulos, K., & Nikolopoulou, V. (2013) · Europe PMC (PubMed Central) · Cited by 45
Berding, A., Witte, C., Gottschald, M., Kaltz, B., Weiland, R., Gerlich, C., Reusch, A., Kruis, W., & Faller, H. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000452989 · Cited by 42
Eder, P., Łodyga, M., Gawron-Kiszka, M., Dobrowolska, A., Gonciarz, M., Hartleb, M., Kłopocka, M., Małecka-Wojciesko, E., Radwan, P., Reguła, J., et al. (2023) · Gastroenterology Review · doi:10.5114/pg.2023.125882 · Cited by 47
ACG Clinical Guideline Update: Preventive Care in Inflammatory Bowel Disease
Farraye, F. A., Melmed, G., Lichtenstein, G. R., Barnes, E. L., Limketkai, B. N., Caldera, F., & Kane, S. V. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003541 · Cited by 44
Molecular Alterations of Colorectal Cancer with Inflammatory Bowel Disease
Yashiro, M. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3646-4 · Cited by 44
“[206] reported that there was no evidence for efficacy of psychological therapy in adult patients with IBD in general.”
BackgroundBessissow, T., Chao, C., Lemieux, C., Restellini, S., Afif, W., Bitton, A., Lakatos, P. L., & Wild, G. (2019) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_566_18 · Cited by 43
“[24-26] Currently no effective psychotherapy addressing coping issues in the IBD population has been shown to result in clinically relevant or significant improvement; although this may change if intervention is provided earlier, and, to those at higher risk.[27] Further prospective studies are needed to assess if ind…”
BackgroundKnowles, S. R., & Mikocka‐Walus, A. A. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.865259 · Cited by 45
“Finally, researchers should also identify and evaluate possible differences across interventions which are transposed from clinic-originated studies versus those developed speci fi cally online [15,33,35].”
BackgroundAdjuvant therapy with antidepressants for the management of inflammatory bowel disease
Mikocka‐Walus, A. A., Fielder, A. L., Prady, S. L., Esterman, A., Knowles, S. R., & Andrews, J. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012680 · Cited by 43
Łodyga, M., Eder, P., Gawron-Kiszka, M., Dobrowolska, A., Gonciarz, M., Hartleb, M., Kłopocka, M., Małecka-Wojciesko, E., Radwan, P., Reguła, J., et al. (2021) · Gastroenterology Review · doi:10.5114/pg.2021.110914 · Cited by 41
“So far, no data are available to show that any psychological intervention (such as behavioral and cognitive therapy) has any impact on CD remission rates [307, 308].”
BackgroundInflammatory Bowel Disease Nurse—Practical Messages
Rosso, C., Aaron, A. A., Armandi, A., Caviglia, G. P., Vernero, M., Saracco, G. M., Astegiano, M., Bugianesi, E., & Ribaldone, D. G. (2021) · Nursing Reports · doi:10.3390/nursrep11020023 · Cited by 40
“While the effects have not been completely demonstrated, psychological intervention or therapy assistance could be useful for patients who are showing higher levels of concern [14].”
BackgroundFreitas, T. H. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i21.6713 · Cited by 42
IBS-like symptoms in patients with ulcerative colitis
Gracie, D. J., & Ford, A. C. (2015) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s58153 · Cited by 42
“A Cochrane review investigated the efficacy of psychotherapy, patient education, and relaxation techniques for IBD.(90) Outcomes assessed included health-related quality of life, coping, emotional status, and disease activity.”
Schmidt, S., Markwart, H., Bomba, F., Muehlan, H., Findeisen, A., Kohl, M., Menrath, I., & Thyen, U. (2018) · European Journal of Pediatrics · doi:10.1007/s00431-017-3080-z · Cited by 39
Modifiable Environmental Factors in Inflammatory Bowel Disease
Burke, K. E., Boumitri, C., & Ananthakrishnan, A. N. (2017) · Current Gastroenterology Reports · doi:10.1007/s11894-017-0562-0 · Cited by 36
The role of hypnotherapy for the treatment of inflammatory bowel diseases
Moser, G. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.917955 · Cited by 33
“Psychotherapy is not routinely recommended for IBD [18].”
BackgroundHolistic healthcare in inflammatory bowel disease: time for patient-centric approaches?
Sudhakar, P., Wellens, J., Verstockt, B., Ferrante, M., Sabino, J., & Vermeire, S. (2022) · Gut · doi:10.1136/gutjnl-2022-328221 · Cited by 35
Sturm, A., Atreya, R. N., Bettenworth, D., Bokemeyer, B., Dignass, A. U., Ehehalt, R., Germer, C.-T., Grunert, P., Helwig, U., Horisberger, K., et al. (2024) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2309-6123 · Cited by 38
Tang, W. S. W., Chiang, C. L. L., Kwang, K. W., & Zhang, M. W. B. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1001232 · Cited by 33
“Treatment itself can also add to the risk of the development of depression—especially so with the use of pharmacological interventions such as corticosteroids and antibiotics, which include depression as a potential side effect (54, 55).”
BackgroundOxelmark, L., Lindberg, A., Löfberg, R., Sternby, B., Eriksson, A., Almer, S. H., Befrits, R., Fossum, B., Karlén, P., Broström, O., et al. (2016) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000710 · Cited by 30
Mind–Body Interventions for Pediatric Inflammatory Bowel Disease
Yeh, A. M., Wren, A. A., & Golianu, B. J. (2017) · Children · doi:10.3390/children4040022 · Cited by 33
“A Cochrane review from 2011 [41] concluded that there was no evidence for psychological interventions in adults with IBD; however, the authors noted more empirical evidence for the use of psychotherapy among pediatric populations with IBD.”
BackgroundInfluentialHypnotherapy for Inflammatory Bowel Disease Across the Lifespan
Szigethy, E. (2015) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2015.1040112 · Cited by 31
“…number of studies showing that psychological interventions can be effective in improving quality of life in patients with IBD and can influence processes in both the brain and the gut (Goodhand et al., 2009; McCombie, Mulder, & Gearry, 2013; Timmer et al., 2011; Von Wietersheim & Kessler, 2006).”
BackgroundMikocka‐Walus, A. A., Gordon, A. L., Stewart, B. J., & Andrews, J. M. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-93 · Cited by 29
“While studies into psychological therapies [4] have recently been conducted, antidepressants have not been widely studied in the context of IBD.”
BackgroundPerkes, S. J., Bowman, J., & Penkala, S. (2013) · Journal of Health Psychology · doi:10.1177/1359105313496445 · Cited by 29
“1) was used across all analyses to account for statistical heterogeneity (Timmer et al., 2011).”
InfluentialAfshar, H., Tabatabaeian, M., Roohafza, H., Daghaghzadeh, H., Feizi, A., Sharbafchi, M. R., Tabatabaeian, M., Naji, F., & Adibi, P. (2015) · Journal of Research in Medical Sciences · doi:10.4103/1735-1995.165962 · Cited by 28
“[26] These treatments must be comprehensive and include several aspects of the psychological health of the patients.”
Quality of Life and Level of Anxiety in Youths With Inflammatory Bowel Disease in Ireland
Kilroy, S., Nolan, E., & Sarma, K. M. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318214c131 · Cited by 28
“With regard to the specific areas of life that are affected by IBD, Timmer et al (11) propose that it has a negative effect on all realms of QOL and others have suggested that the greatest impairment may be in emotional behaviour (Drossman et al (12)).”
BackgroundResultInfluentialLavelle, J., Storan, D., Eswara Murthy, V., De Dominicis, N., Mulcahy, H. E., & McHugh, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102757 · Cited by 23
“contrast somewhat with those of earlier reviews, which observed minimal-to-no effectiveness of psychotherapeutic interventions in intervening with depression, quality of life (QoL), coping, and anxiety [20,21].”
ResultInviting Patients with Inflammatory Bowel Disease to Active Involvement in Their Own Care
Hueppe, A., Langbrandtner, J., & Raspe, H. H. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000044 · Cited by 24
“and disease activity over a period of 1 year.(29) In a comprehensive review including 13 randomized controlled trials, only few small long-term beneficial effects on health care utilization and disease activity were found.”
BackgroundDam, A. N., Berg, A. M., & Farraye, F. A. (2013) · Europe PMC (PubMed Central) · Cited by 24
Mählmann, L., Gerber, M., Furlano, R. I., Légeret, C., Kalak, N., Holsboer‐Trachsler, E., & Brand, S. (2017) · Mental health and physical activity · doi:10.1016/j.mhpa.2017.09.002 · Cited by 25
Adjuvant therapy with antidepressants for the management of inflammatory bowel disease
Mikocka-Walus, A., Prady, S. L., Pollok, J., Esterman, A. J., Gordon, A. L., Knowles, S., & Andrews, J. M. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012680.pub2 · Cited by 59
Evertsz’, F. B., Bockting, C. L., Stokkers, P. C., Hinnen, C., Sanderman, R., & Sprangers, M. A. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-227 · Cited by 30
“Results from a recent meta-analysis of psychological interventions for treatment of IBD showed that current psychological treatment is not effective among IBD patients [15].”
BackgroundInfluentialChen, J., Chen, X., Sun, Y., Xie, Y., Wang, X., Li, R., & Hesketh, T. M. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-02003-0 · Cited by 23
Tran, L., & Mulligan, K. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy299 · Cited by 22
Artom, M., Czuber‐Dochan, W., Sturt, J. A., & Norton, C. S. (2017) · Trials · doi:10.1186/s13063-017-1926-3 · Cited by 24
Interventions for the management of abdominal pain in ulcerative colitis
Sinopoulou, V., Gordon, M. A., Dovey, T. M., & Akobeng, A. K. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013589.pub2 · Cited by 21
Reusch, A., Weiland, R., Gerlich, C., Dreger, K., Derra, C., Mainos, D., Tuschhoff, T., Berding, A., Witte, C. E., Kaltz, B., et al. (2016) · Health Education Research · doi:10.1093/her/cyw042 · Cited by 21
Assche, G. V., Dignass, A. U., Bokemeyer, B., Danese, S., Gionchetti, P., Moser, G., Beaugerie, L., Gomollón, F., Häuser, W., Herrlinger, K. R., et al. (2012) · Cited by 20
Mental Illnesses in Inflammatory Bowel Diseases: mens sana in corpore sano
Bartocci, B., Buono, A. D., Gabbiadini, R., Busacca, A., Quadarella, A., Repici, A., Mencaglia, E., Gasparini, L., & Armuzzi, A. (2023) · Medicina · doi:10.3390/medicina59040682 · Cited by 21
“However, the available meta-analyses did not endorse this evidence: a first systematic review with meta-analysis, in 2011, found that psychotherapy had no effect on the QoL, emotional status, or disease activation in adult patients with IBD, while in adolescents, psychological interventions appeared to be beneficial,…”
Result
Metadata
- Authors
- Timmer, A., Preiss, J. C., Motschall, E., Rücker, G., Jantschek, G., & Moser, G.
- Affiliations
- Leibniz Institute for Prevention Research and Epidemiology - BIPS (DE)
- Charité – Universitätsmedizin Berlin (DE)
- University Medical Center Freiburg (DE)
- University Hospital Schleswig-Holstein (DE)
- Medical University of Vienna (AT)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2011-02-15
- Issue
- 2
- Pages
- CD006913-CD006913
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W1830145075
- Cited by
- 187
- References
- 133
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 11 · 2021: 18 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 18 · 2016: 14 · 2015: 22 · 2014: 17 · 2013: 14 · 2012: 13
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Update notices
- new_version (2025-04-17)
- Open access
- closed
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- inflammatory bowel disease, psychological intervention, psychotherapy, patient education, relaxation techniques, health-related quality of life, coping, depression, disease activity, remission, adolescents, children, risk of bias, attrition bias, publication bias
- MeSH terms
- Adolescent, Adult, Colitis, Ulcerative, Crohn Disease, Depression, Humans, Patient Education as Topic, Psychotherapy, Quality of Life, Inflammatory Bowel Diseases, Randomized Controlled Trials as Topic
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