Cognitive-behavioural therapy has no effect on disease activity but improves quality of life in subgroups of patients with inflammatory bowel disease: a pilot randomised controlled trial
Open accessAbstract
BACKGROUND: Studies have demonstrated usefulness of cognitive-behavioural therapy (CBT) in managing distress in inflammatory bowel disease (IBD); however, few have focused on IBD course. The present trial aimed to investigate whether adding CBT to standard treatment prolongs remission in IBD in comparison to standard therapy alone. METHODS: A 2-arm parallel pragmatic randomised controlled trial (+CBT - standard care plus either face-to-face (F2F) or online CBT over 10 weeks versus standard care alone (SC)) was conducted with adult patients in remission. IBD remission at 12 months since baseline was the primary outcome measure while the secondary outcome measures were mental health status and quality of life (QoL). Linear mixed-effect models were used to compare groups on outcome variables while controlling for baseline. RESULTS: Participants were 174 patients with IBD (90 +CBT, 84 SC). There was no difference in remission rates between groups, with similar numbers flaring at 12 months. Groups did not differ in anxiety, depression or coping at 6 or 12 months (p >0.05). When only participants classified as 'in need' (young, high baseline IBD activity, recently diagnosed; poor mental health) were examined in the post-hoc analysis (n = 74, 34 CBT and 40 controls), CBT significantly improved mental QoL (p = .034, d = .56) at 6 months. Online CBT group had a higher score on Precontemplation than the F2F group, which is consistent with less developed coping with IBD in the cCBT group (p = .045). CONCLUSIONS: Future studies should direct psychological interventions to patients 'in need' and attempt to recruit larger samples to compensate for significant attrition when using online CBT. TRIAL REGISTRATION: The protocol was registered on 21/10/2009 with the Australian New Zealand Clinical Trials Registry (ID: ACTRN12609000913279).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This pattern of higher retention in active control is not unusual and has been found in similar trials testing psychotherapy for IBD.
“This is not an unusual finding and has been found in similar trials testing psychotherapy for IBD.37”
From Feasibility, Acceptability, and Preliminary Efficacy of Acceptance Commitment Therapy for Adults Living With Inflammatory Bowel Disease and Distress. (2024) · cites this paper as [37]
The Results (Attrition) report higher dropout in the CBT group than in the standard-care group at both 6 and 12 months, supporting the claim that control participants were retained at a higher rate in a psychotherapy trial for IBD. The paper does not establish that this pattern is common across similar trials, and its comparator was standard care rather than a control described as active. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe present trial showed high retention, comparable to or better than other trials testing psychotherapy, specifically CBT, in an online only setting for IBD.
“The present trial showed high retention, which is comparable to or better than other trials testing psychotherapy, specifically CBT, in an online only setting for IBD.37,40”
From Feasibility, Acceptability, and Preliminary Efficacy of Acceptance Commitment Therapy for Adults Living With Inflammatory Bowel Disease and Distress. (2024) · cites this paper as [37]
The Methods (Design and Procedure) describe an IBD trial that offered both online and face-to-face CBT, so it was not an online-only trial. The Results (Attrition) provide a relevant comparison for the online CBT subgroup: 48% were lost to follow-up at six months and 60% at twelve months. The cited paper supports an online-CBT retention comparison, but not the description of the whole trial as online-only. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
(1992) · PubMed · Cited by 33,716 · see citing works
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033 · see citing works
(1970) · Cited by 24,983 · see citing works
Depression and quality of life in older persons: A review
Sivertsen, H., Bjørkløf, G. H., Engedal, K., Selbæk, G., & Helvik, A.-S. (2015) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000437299 · Cited by 14,152 · see citing works
The social readjustment rating scale
Holmes, T. H., & Rahe, R. H. (1967) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(67)90010-4 · Cited by 11,174 · see citing works
You want to measure coping but your protocol’ too long: Consider the brief cope
Carver, C. S. (1997) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0401_6 · Cited by 7,361 · see citing works
The empirical status of cognitive-behavioral therapy: A review of meta-analyses
Butler, A. C., Chapman, J. E., Forman, E. M., & Beck, A. T. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2005.07.003 · Cited by 3,215 · see citing works
Development of a Crohn's Disease Activity Index
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80163-1 · Cited by 3,152 · see citing works
Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147 · see citing works
Short form 36 (SF36) health survey questionnaire: normative data for adults of working age.
Jenkinson, C., Coulter, A., & Wright, L. (1993) · BMJ · doi:10.1136/bmj.306.6890.1437 · Cited by 1,714 · see citing works
Hoffman, S. G., & Smits, J. A. J. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0415 · Cited by 1,420 · see citing works
A simple clinical colitis activity index
Walmsley, R. S., Ayres, R., Pounder, R. E., & Allan, R. N. (1998) · Gut · doi:10.1136/gut.43.1.29 · Cited by 1,320 · see citing works
Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management
Graff, L. A., Walker, J. R., & Bernstein, C. N. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20873 · Cited by 586 · see citing works
Ford, A. C., Talley, N. J., Schoenfeld, P. S., Quigley, E. M. M., & Moayyedi, P. (2009) · Gut · doi:10.1136/gut.2008.163162 · Cited by 582 · see citing works
Mittermaier, C., Dejaco, C., Waldhoer, T., Oefferlbauer-Ernst, A., Miehsler, W., Beier, M., Tillinger, W., Gangl, A., & Moser, G. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000106907.24881.f2 · Cited by 532 · see citing works
The Reduction in Colorectal Cancer Mortality After Colonoscopy Varies by Site of the Cancer
Singh, H., Nugent, Z. J., Demers, A. A., Kliewer, E. V., Mahmud, S. M., & Bernstein, C. N. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.052 · Cited by 481 · see citing works
A prospective population-based study of triggers of symptomatic flares in IBD
Bernstein, C. N., Singh, S., Graff, L. A., Walker, J. R., Miller, N., & Cheang, M. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.140 · Cited by 400 · see citing works
Waller, R., & Gilbody, S. (2009) · Psychological Medicine · doi:10.1017/s0033291708004224 · Cited by 393 · cited 1× · see citing works
“However, high attrition is a known phenomenon in the self-directed psychotherapy studies for those in the intervention group [18,45], and thus our study does not differ in respect to this from other research in the field.”
ResultKaltenthaler, E., Brazier, J., De Nigris, E., Tumur, I., Ferriter, M., Beverley, C., Parry, G., Rooney, G., & Sutcliffe, P. (2006) · Health Technology Assessment · doi:10.3310/hta10330 · Cited by 357 · see citing works
Ghia, J.-E., Blennerhassett, P., & Collins, S. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32849 · Cited by 233 · cited 1× · see citing works
“In addition, a psycho-neuroimmunological view of IBD has developed in recent years due to intriguing observations that psychological status can directly influence inflammatory lesions in the gut [1].”
BackgroundMaunder, R., & Levenstein, S. (2008) · Current Molecular Medicine · doi:10.2174/156652408784533832 · Cited by 198 · see citing works
Psychotherapy mediated by remote communication technologies: a meta-analytic review
Bee, P. E., Bower, P., Lovell, K., Gilbody, S., Richards, D., Gask, L., & Roach, P. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-60 · Cited by 189 · cited 1× · see citing works
“Based on previous studies [17,18] we assumed that CBT would perform consistently irrespective of delivery mode.”
MethodPsychological interventions for treatment of inflammatory bowel disease
Timmer, A., Preiss, J. C., Motschall, E., Rücker, G., Jantschek, G., & Moser, G. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006913.pub2 · Cited by 187 · cited 3× · see citing works
“In recent years, several reviews have been published on the efficacy of psychotherapy for QoL, emotional status and remission/flare status in IBD [7-10].”
BackgroundMethodSZIGETHY, E., KENNEY, E., CARPENTER, J., HARDY, D. M., FAIRCLOUGH, D., BOUSVAROS, A., KELJO, D., WEISZ, J., BEARDSLEE, W. R., NOLL, R., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180f6341f · Cited by 183 · see citing works
Bai, A., Ma, A. G., Yong, M., Weiss, C. R., Ma, Y., Guan, Q., Bernstein, C. N., & Peng, Z. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.08.009 · Cited by 181 · see citing works
Gut-directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis
Keefer, L., Taft, T. H., Kiebles, J. L., Martinovich, Z., Barrett, T. A., & Palsson, O. S. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12449 · Cited by 132 · see citing works
Evaluation of a psychological treatment for inflammatory bowel disease
Schwarz, S. P., & Blanchard, E. B. (1991) · Behaviour Research and Therapy · doi:10.1016/0005-7967(91)90045-5 · Cited by 131 · see citing works
Information needs and preferences of recently diagnosed patients with inflammatory bowel disease
Bernstein, K. I., Promislow, S., Carr, R., Rawsthorne, P. E., Walker, J. R., & Bernstein, C. N. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21363 · Cited by 130 · see citing works
Cámara, R. J. A., Ziegler, R., Begré, S., Schoepfer, A. M., & von Känel, R. (2009) · Digestion · doi:10.1159/000226087 · Cited by 106 · see citing works
Psychotherapy for inflammatory bowel disease: a review and update
McCombie, A. M., Mulder, R. T., & Gearry, R. B. (2013) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2013.02.004 · Cited by 105 · see citing works
Psychotherapy with chronic inflammatory bowel disease patients: A Review
von Wietersheim, J., & Kessler, H. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000236925.87502.e0 · Cited by 103 · see citing works
Knowles, S. R., Monshat, K., & Castle, D. J. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e318296ae5a · Cited by 102 · see citing works
M., M., U., B., N., N., R., O., & V., S. M. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310003110 · Cited by 94 · see citing works
Which patients with IBD need psychological interventions? A controlled study
Miehsler, W., Weichselberger, M., Öfferlbauer-Ernst, A., Dejaco, C., Reinisch, W., Vogelsang, H., Machold, K., Stamm, T., Gangl, A., & Moser, G. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20462 · Cited by 82 · see citing works
IBD Around the world: Comparing the epidemiology, diagnosis, and treatment
Baumgart, D. C., Bernstein, C. N., Abbas, Z., Colombel, J. F., Day, A. S., D’Haens, G., Dotan, I., Goh, K., Hibi∥, T., Kozarek, R. A., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21409 · Cited by 77 · see citing works
Effect of psychotherapy and relaxation on the psychosocial and somatic course of Crohn's disease
Keller, W., Pritsch, M., von Wietersheim, J., Scheib, P., Osborn, W., Balck, F. B., Dilg, R., Schmelz-Schumacher, E., Doppl, W., Jantschek, G., et al. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00122-3 · Cited by 67 · see citing works
Carr, J. L., Moffett, J. A. K., Sharp, D. M., & Haines, D. R. (2006) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-7-101 · Cited by 42 · see citing works
Sibaja, M. Á. D., Moreno, M. I. C., & Hesse, B. M. (2007) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082007001000006 · Cited by 42 · see citing works
Mikocka-Walus, A. A., Gordon, A. L., Stewart, B. J., & Andrews, J. M. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2011.06.006 · Cited by 34 · see citing works
Self-citationCase study: Longitudinal treatment of adolescents with depression and inflammatory bowel disease
SZIGETHY, E., CARPENTER, J., BAUM, E., KENNEY, E., BAPTISTA-NETO, L., BEARDSLEE, W. R., & DeMASO, D. R. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000198591.45949.a4 · Cited by 33 · see citing works
Crohn’s Is Not a 6-Week Disease
Lichtenstein, G. R., Hanauer, S. B., Kane, S. V., & Present, D. H. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200407002-00002 · Cited by 29 · see citing works
Demographic associations with stage of readiness to screen for colorectal cancer
Duncan, A., Wilson, C. J., Cole, S. R., Mikocka‐Walus, A. A., Turnbull, D. A., & Young, G. P. (2009) · Health Promotion Journal of Australia · doi:10.1071/he09007 · Cited by 23 · see citing works
Singh, H., Penfold, R. B., Coster, C. D., Au, W., Bernstein, C. N., & MOFFATT, M. E. K. (2010) · Canadian Journal of Gastroenterology · doi:10.1155/2010/714591 · Cited by 22 · see citing works
Bernstein, C. N. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.04.014 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gracie, D. J., Irvine, A. J., Sood, R., Mikocka-Walus, A., Hamlin, P. J., & Ford, A. C. (2017) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30206-0 · Cited by 271 · see citing works
Gracie, D. J., Williams, C. J. M., Sood, R., Mumtaz, S., Bholah, H. M., Hamlin, J. P., & Ford, A. C. (2016) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.59 · Cited by 173 · see citing works
Etiology and Treatment of Pain and Psychosocial Issues in Patients With Inflammatory Bowel Diseases
Regueiro, M., Greer, J. B., & Szigethy, E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.036 · Cited by 142 · see citing works
The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases
Peppas, S., Pansieri, C., Piovani, D., Danese, S., Peyrin‐Biroulet, L., Tsantes, A. G., Brunetta, E., Tsantes, A. Ε., & Bonovas, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030377 · Cited by 114 · see citing works
Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation?
Moulton, C. D., Pavlidis, P., Norton, C. S., Norton, S., Pariante, C. M., Hayee, B., & Powell, N. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13276 · Cited by 102 · see citing works
The Brain-Gut Axis and Stress in Inflammatory Bowel Disease
Bernstein, C. N. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.08.006 · Cited by 99 · see citing works
Click, B. H., Rivers, C. R., Κoutroubakis, I. E., Babichenko, D., Anderson, A. J. M., Hashash, J. G., Dunn, M. A., Schwartz, M. B., Swoger, J. M., Baidoo, L., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000763 · Cited by 94 · see citing works
Depression and Anxiety Disorders in Patients With Inflammatory Bowel Disease
Hu, S., Chen, Y., Chen, Y., & Wang, C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.714057 · Cited by 91 · see citing works
Bennebroek Evertsz', F., Sprangers, M. A. G., Sitnikova, K., Stokkers, P. C. F., Ponsioen, C. Y., Bartelsman, J. F. W. M., van Bodegraven, A. A., Fischer, S., Depla, A. C. T. M., Mallant, R. C., et al. (2017) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000227 · Cited by 84 · see citing works
Riggott, C., Mikocka-Walus, A., Gracie, D. J., & Ford, A. C. (2023) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(23)00186-3 · Cited by 83 · see citing works
Self-citationMikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. M. (2017) · International Journal of Behavioral Medicine · doi:10.1007/s12529-016-9580-9 · Cited by 78 · see citing works
Zhang, M., Hong, L., Zhang, T., Lin, Y., Zheng, S., Zhou, X., Fan, R., Wang, Z., Zhang, C.-L., & Zhong, J. (2016) · Patient Preference and Adherence · doi:10.2147/ppa.s118413 · Cited by 76 · see citing works
Sturm, A., Stallmach, A., Atreya, R. N., Bettenworth, D., Bokemeyer, B., Dignass, A. U., Ehehalt, R., Germer, C. T., Grunert, P., Helwig, U., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1713-3941 · Cited by 77 · see citing works
Sleep and Inflammatory Bowel Disease: An Important Bi-Directional Relationship
Qazi, T., & Farraye, F. A. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy334 · Cited by 75 · see citing works
Lores, T. J., Goess, C., Mikocka‐Walus, A. A., Collins, K., Burke, A. L. J., Chur‐Hansen, A., Delfabbro, P., & Andrews, J. M. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz026 · Cited by 70 · see citing works
Jordan, C., Sin, J., Fear, N. T., & Chalder, T. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.06.001 · Cited by 66 · see citing works
Psychosocial interventions for adults with newly diagnosed chronic disease: A systematic review
Akyirem, S., Forbes, A., Wad, J. L., & Due-Christensen, M. (2022) · Journal of Health Psychology · doi:10.1177/1359105321995916 · Cited by 60 · see citing works
DUFF, W. R. D., Haskey, N., Potter, G., Alcorn, J., Hunter, P. V., & Fowler, S. A. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i28.3055 · Cited by 60 · see citing works
Tarricone, I., Regazzi, M. G., Bonucci, G., Rizzello, F., Carini, G., Muratori, R., Poggioli, G., & Campieri, M. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.07.001 · Cited by 53 · see citing works
Illness Perceptions and Outcomes in Patients with Inflammatory Bowel Disease: Is Coping a Mediator?
van Erp, S. J. H., Brakenhoff, L. K. P. M., Vollmann, M., van der Heijde, D. M. F. M., Veenendaal, R. A., Fidder, H. H., Hommes, D. W., Kaptein, A. A., Jong, A. E. V. D. M., & Scharloo, M. (2016) · International Journal of Behavioral Medicine · doi:10.1007/s12529-016-9599-y · Cited by 52 · see citing works
Chan, W. P. W., Shim, H. H., Lim, M. S., Sawadjaan, F. L. B., Isaac, S. P., Chuah, S. W., Leong, R. W. L., & Kong, C. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.08.020 · Cited by 51 · see citing works
Hanlon, I., Hewitt, C. E., Bell, K. J., Phillips, A., & Mikocka‐Walus, A. A. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14840 · Cited by 50 · see citing works
Hunt, M. G., Loftus, P., Accardo, M., Keenan, M., Cohen, L., & Osterman, M. T. (2019) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-019-09621-7 · Cited by 50 · see citing works
The effect of psychotherapy on quality of life in IBD Patients: A systematic review
Paulides, E., Boukema, I., van der Woude, C. J., & de Boer, N. K. H. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa144 · Cited by 47 · see citing works
Seaton, N., Hudson, J. L., Harding, S., Norton, S., Mondelli, V., Jones, A. S. K., & Moss-Morris, R. E. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2023.104910 · Cited by 45 · see citing works
ACG Clinical Guideline Update: Preventive Care in Inflammatory Bowel Disease
Farraye, F. A., MELMED, G. Y., Lichtenstein, G. R., Barnes, E. L., Limketkai, B. N., Caldera, F., & Kane, S. V. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003541 · Cited by 44 · see citing works
Development and Current State of Digital Therapeutics for Irritable Bowel Syndrome
Brenner, D. M., Kassebaum-Ladewski, A., & Kinsinger, S. W. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.09.013 · Cited by 45 · see citing works
Adjuvant therapy with antidepressants for the management of inflammatory bowel disease
Mikocka‐Walus, A. A., Fielder, A. L., Prady, S. L., Esterman, A., Knowles, S. R., & Andrews, J. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012680 · Cited by 43 · see citing works
Inflammatory Bowel Disease Patient Experiences with Psychotherapy in the Community
Craven, M. R. A., Quinton, S., & Taft, T. (2018) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-018-9576-5 · Cited by 35 · see citing works
Davis, S. P., Bolin, L. P., Crane, P. B., & Crandell, J. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.538741 · Cited by 32 · see citing works
Nemirovsky, A., Ilan, K., Lerner, L., Cohen-Lavi, L., Schwartz, D., Goren, G., Sergienko, R., Greenberg, D., Slonim‐Nevo, V., Sarid, O., et al. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100407 · Cited by 34 · see citing works
Sturm, A., Atreya, R. N., Bettenworth, D., Bokemeyer, B., Dignass, A. U., Ehehalt, R., Germer, C.-T., Grunert, P., Helwig, U., Horisberger, K., et al. (2024) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2309-6123 · Cited by 33 · see citing works
Li, C., Hou, Z., Liu, Y., Ji, Y.-N., & Xie, L. (2018) · International Journal of Nursing Practice · doi:10.1111/ijn.12699 · Cited by 31 · see citing works
Mikocka‐Walus, A. A., Druitt, M. L., O’Shea, M., Skvarc, D., Watts, J. J., Esterman, A., Tsaltas, J., Knowles, S. R., Harris, J., Dowding, C., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-046603 · Cited by 30 · see citing works
Chen, Y., Chen, X., Lin, S., Huang, S., Li, L., Hong, M., Li, ., Ma, L., & Ma, J. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003389 · Cited by 28 · see citing works
Luo, H., Sun, Y., Li, Y., Lv, H., Sheng, L., Wang, L., & Qian, J. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.07.013 · Cited by 25 · see citing works
Dober, M., Mikocka-Walus, A., Evans, S., Beswick, L., Emerson, C., & Olive, L. (2021) · Psychotherapy Research · doi:10.1080/10503307.2020.1813915 · Cited by 25 · see citing works
“…of patients at “in need” due to factors of poor mental health, difficulty controlling IBD symptoms, ongoing functional gastrointestinal symptoms, recently diagnosed, or recent transition to adult care; may receive optimal benefit from psychological intervention (Mikocka-Walus et al., 2015).”
Backgroundvan den Brink, G., Stapersma, L., Bom, A. S., Rizopolous, D., van der Woude, C. J., Stuyt, R. J. L., Hendriks, D. M., van der Burg, J. A. T., Beukers, R., Korpershoek, T. A., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz073 · Cited by 23 · see citing works
Chen, J., Chen, X., Sun, Y., Xie, Y., Wang, X., Li, R., & Hesketh, T. M. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-02003-0 · Cited by 23 · see citing works
A Systematic Review of Self-Management Interventions for Patients with Inflammatory Bowel Disease
Iizawa, M., Hirose, L., Nunotani, M., Nakashoji, M., Tairaka, A., & Fernandez, J. L. (2023) · Inflammatory Intestinal Diseases · doi:10.1159/000530021 · Cited by 23 · see citing works
Hughes, P. A., Costello, S. P., Bryant, R. V., & Andrews, J. M. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00442.2015 · Cited by 22 · see citing works
Romano, D., Chesterman, S., Fuller-Tyszkiewicz, M., Evans, S., Dober, M., Gearry, R., Gibson, P. R., Knowles, S., McCombie, A., O, E., et al. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad122 · Cited by 19 · see citing works
“37,40 This suggests that hybrid designs that include a mixture of self-directed and therapist-led content are important for future work to incorporate in trials going forward.”
BackgroundBernabeu, P., Román, C. J. V.-D. H., Marín, J. R., Gutiérrez, A., Alonso, M. R., Zapater, P., Jover, R., & Sempere, L. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18105439 · Cited by 18 · see citing works
Zhao, S.-R., Ni, X.-M., Zhang, X., & Tian, H. W. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i21.3446 · Cited by 17 · see citing works
Rohde, J. A., Barker, J., & Noar, S. M. (2019) · Translational Behavioral Medicine · doi:10.1093/tbm/ibz166 · Cited by 17 · see citing works
Ilan, K., Motro, Y., Nemirovsky, A., Schwartz, D., Goren, G., Sergienko, R., Greenberg, D., Slonim‐Nevo, V., Sarid, O., Friger, M. D., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2337269 · Cited by 16 · see citing works
Jordan, C., Hayee, B., & Chalder, T. (2019) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2326 · Cited by 14 · see citing works
Wang, C., Sheng, Y., Yu, L., Tian, F., Xue, Y., & Zhai, Q. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114653 · Cited by 14 · see citing works
The New Proactive Approach and Precision Medicine in Crohn’s Disease
Zittan, E., Gralnek, I. M., & Berns, M. S. (2020) · Biomedicines · doi:10.3390/biomedicines8070193 · Cited by 14 · see citing works
Zhao, E., Yu, Q., Abdoulaye, I. A., Mu, Y., Shi, Y., & Zhu, L. (2020) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2020.06.002 · Cited by 13 · see citing works
Benedetti, F., Palladini, M., D'Orsi, G., Furlan, R., Ciceri, F., Rovere, P. Q., & Mazza, M. G. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.04.077 · Cited by 13 · see citing works
Oddsson, S. J., Gunnarsdottir, T., Jóhannsdóttir, L. G., Ámundadóttir, M. L., Frimannsdottir, A., Molander, P., Ylanne, A. K., Íslind, A. S., Óskarsdóttir, M., & Þorgeirsson, T. (2023) · JMIR Formative Research · doi:10.2196/39331 · Cited by 13 · see citing works
Kalogeropoulou, M., Karaivazoglou, K., Κωνσταντοπούλου, Γ., Vinni, E., Sotiropoulos, C., Tourkochristou, E., Aggeletopoulou, I., Lourida, T., Labropoulou, E.-P., Διαμαντοπούλου, Γ., et al. (2024) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjae144 · Cited by 12 · see citing works
Cognitive Behavioral Therapy for IBD
Mikocka‐Walus, A. A., Andrews, J. M., & Bampton, P. A. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000672 · Cited by 11 · see citing works
Psychological interventions for treatment of inflammatory bowel disease
Tiles-Sar, N., Neuser, J., de Sordi, D., Baltes, A., Preiß, J., Moser, G., & Timmer, A. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006913.pub3 · Cited by 12 · see citing works
Treating anxiety and depression in inflammatory bowel disease: a systematic review
Prendergast, K. L., Gowey, M. A., Barnes, M. J., Keller, C. V., Horne, C., & Young, J. N. (2021) · Psychology and Health · doi:10.1080/08870446.2020.1867135 · Cited by 10 · see citing works
Naude, C., Skvarc, D., Biurra, Y. C., Blake, L., Evans, S., Knowles, S. R., Eric, O., Prasertsung, C., Russell, L., Bassili, A., et al. (2024) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2024.111984 · Cited by 8 · see citing works
Gregory, V. L. (2019) · Journal of Evidence-Based Social Work · doi:10.1080/26408066.2019.1610682 · Cited by 7 · see citing works
Psychische Störungen bei somatischen Krankheiten
Kapfhammer, H. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_88 · Cited by 6 · see citing works
Emerson, C., Skvarc, D., Mikocka‐Walus, A. A., OLIVE, L. S., Gibson, P. R., & Fuller‐Tyszkiewicz, M. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08468-9 · Cited by 6 · see citing works
Lores, T. J., Krishnaprasad, K., Connor, S. J., Cabaero, A., & Andrews, J. M. (2023) · Internal Medicine Journal · doi:10.1111/imj.15989 · Cited by 5 · see citing works
Hanlon, I., Hewitt, C., Evans, S., Taylor, J., Selinger, C., & Mikocka-Walus, A. (2022) · Journal of Health Psychology · doi:10.1177/1359105320945001 · Cited by 4 · see citing works
Holistic care in inflammatory bowel disease: is it in REACH?
Said, H., Moulton, C. D., Hart, A. L., & Keefer, L. (2025) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaf227 · Cited by 3 · see citing works
Orr, R., Skvarc, D., Emerson, C., Beswick, L., OLIVE, L. S., David, S., & Mikocka‐Walus, A. A. (2022) · Psychology Health & Medicine · doi:10.1080/13548506.2022.2132408 · Cited by 3 · see citing works
Emerson, C., Skvarc, D., Fuller‐Tyszkiewicz, M., OLIVE, L. S., Gibson, P. R., & Mikocka‐Walus, A. A. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07476-x · Cited by 3 · see citing works
Wang, H., Ding, J., Liu, G., Sun, G., Zhang, X., Xiao, W., Cai, Y., & Lin, A. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1630034 · Cited by 2 · see citing works
Jäghult, S., Adamina, M., Farrell, D., Bager, P., Czuber‐Dochan, W., Kemp, K., Boontje, N., D’Amico, F., Dewitte, G., Haj, O., et al. (2026) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjag054 · Cited by 2 · see citing works
Psychische Störungen bei somatischen Krankheiten
Kapfhammer, H. (2015) · Springer eBooks · doi:10.1007/978-3-642-45028-0_88-1 · Cited by 2 · see citing works
Patricia, F., Lesley A, G., Gia Ly, J., Maia, K., Shelby, A., Dale, D., Teaghan, P., & Charles N, B. (2022) · Journal of Depression and Anxiety Disorders · doi:10.36959/362/481 · Cited by 1 · see citing works
Internet-Delivered Cognitive Behavioural Therapy for the Management of Chronic Non-Cancer Pain
CADTH (2022) · Canadian Journal of Health Technologies · doi:10.51731/cjht.2022.462 · Cited by 1 · see citing works
Emerson, C., Klas, A., Gibson, P. R., OLIVE, L. S., Fuller‐Tyszkiewicz, M., & Mikocka‐Walus, A. A. (2026) · JGH Open · doi:10.1002/jgh3.70363 · Cited by 1 · see citing works
Effectiveness of Cardiovascular Specific Psychotherapy on Heart Disease Patients’ Quality of Life
Shal, R. S., Sharbaf, H. A., abdkhodaie, M. S., & Tayyebi, M. (2016) · ranian Journal of Health Education and Health Promotion · doi:10.18869/acadpub.ihepsaj.4.3.244 · Cited by 1 · see citing works
Häuser, W. (2020) · Springer eBooks · doi:10.1007/978-3-662-59104-8_36 · Cited by 1 · see citing works
Hunt, M. G., Tse, C. S., Suh, L. H. K., Yang, E., Bui, C., Davis, A., Siddiqi, R., & Tian, V. (2025) · Behaviour Research and Therapy · doi:10.1016/j.brat.2025.104702 · Cited by 1 · see citing works
Continuous care education for patients with inflammatory bowel disease
Zhao, Y.-E., & Xiu-qin, Z. (2019) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v27.i3.197 · Cited by 1 · see citing works
Gastroenterologie zwischen Immunmodulation und Achtsamkeit
Langhorst, J., & Koch, A. K. (2022) · Ärztliche Psychotherapie · doi:10.21706/aep-17-4-260 · Cited by 1 · see citing works
Chronisch-entzündliche Darmerkrankungen
Langhorst, J., & Koch, A. K. (2024) · Springer eBooks · doi:10.1007/978-3-662-68436-8_11 · Cited by 1 · see citing works
Gracie, D. J. (2018) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Lyall, K. (2021) · Social Science Protocols · doi:10.7565/ssp.v4.6485
Zhao, S.-R., Ni, X.-M., Zhang, X., & Tian, H. W. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i21.3638
边, 姗. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.132355
Su, J., Zou, L., Wang, J., Wang, W., Lu, Y., Li, J., Kang, J., Tang, Z., Yin, A., Ren, H., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5137569
(2025) · Elsevier eBooks · doi:10.1016/b978-3-437-21835-4.00116-5
Salud mental y enfermedad inflamatoria intestinal
Muñoz, T. M. (2025) · Diversitas · doi:10.15332/22563067.11084
Qi-wen, F., Jiang, Y.-L., Ge, X.-Y., & Yang, J.-H. (2026) · World Journal of Psychiatry · doi:10.5498/wjp.119197
Leung, R. S., Lefever, K., McLaughlin, L., Mackay, L., Yiu, E. M., & Blum, S. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107414
- Authors
- Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. M.
- Affiliations
- Flinders University (AU)
- Royal Adelaide Hospital (AU)
- The University of Adelaide (AU)
- University of South Australia (AU)
- Venue
- BMC Gastroenterology
- Published
- 2015-05-02
- Volume
- 15
- Issue
- 1
- Pages
- 54-54
- ISSN
- 1471-230X (ISSN-L)
- PMC
- PMC4427935
- OpenAlex
- W2000130446
- Cited by
- 86
- References
- 45
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 1
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Gastroenterology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- UniSA Research Outputs Repository (University of South Australia) (submittedVersion, other-oa)
- Funders
- University of Warwick
- MSD Australia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- cognitive behavioral therapy, inflammatory bowel disease, remission, disease activity, quality of life, mental health, coping, precontemplation, anxiety, depression, psychological intervention
- MeSH terms
- Adult, Combined Modality Therapy, Female, Health Status, Humans, Male, Mental Health, Middle Aged, Pilot Projects, Quality of Life, Remission Induction, Inflammatory Bowel Diseases, Cognitive Behavioral Therapy, Linear Models, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
