Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: Viewpoint based on a systemic pathogenetic role

Regression Models and Life-Tables

Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793

Nonparametric Estimation from Incomplete Observations

Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519

The PPARα–leukotriene B4 pathway to inflammation control

Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345

Intraadrenal interactions in the regulation of adrenocortical steroidogenesis.

Ehrhart-Bornstein, M., Hinson, J. P., Bornstein, S. R., Scherbaum, W. A., & Vinson, G. P. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.2.0326 · Cited by 600

Pulsating Fluid Flow Increases Nitric Oxide (NO) Synthesis by Osteocytes but Not Periosteal Fibroblasts - Correlation with Prostaglandin Upregulation

Kleinnulend, J., Semeins, C. M., Ajubi, N. E., Nijweide, P. J., & Burger, E. H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2822 · Cited by 425

Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514

The complex role of estrogens in inflammation

Straub, R. H. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0001 · Cited by 1,950

Cyclophosphamide versus placebo in scleroderma lung disease

Tashkin, D. P., Elashoff, R., Clements, P. J., Goldin, J., Roth, M. D., Furst, D. E., Arriola, E., Silver, R., Strange, C., Bolster, M., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055120 · Cited by 1,677

Lost productive time and cost due to common pain conditions in the US workforce

Stewart, W. F. (2003) · JAMA · doi:10.1001/jama.290.18.2443 · Cited by 1,570

Cost of Lost Productive Work Time Among US Workers With Depression

Stewart, W. F. (2003) · JAMA · doi:10.1001/jama.289.23.3135 · Cited by 1,421

Evidence for prescribing exercise as therapy in chronic disease

Pedersen, B. K., & Saltin, B. (2006) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2006.00520.x · Cited by 1,384

Osteoarthritis

Goldring, M. B., & Goldring, S. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21258 · Cited by 1,179

Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases

Powers, J. C., Asgian, J. L., Ekici, Ö. D., & James, K. E. (2002) · Chemical Reviews · doi:10.1021/cr010182v · Cited by 1,090

Stress Hormones, Proinflammatory and Antiinflammatory Cytokines, and Autoimmunity

ELENKOV, I. J., & CHROUSOS, G. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04229.x · Cited by 983

Interleukin-18 and IL-18 Binding Protein

Dinarello, C. A., Novick, D., Kim, S., & Kaplanski, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00289 · Cited by 938

Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

Vincenti, M. P., & Brinckerhoff, C. E. (2002) · Arthritis Research & Therapy · doi:10.1186/ar401 · Cited by 796

Regulation of the expression of inducible nitric oxide synthase

Kleinert, H., Pautz, A., Linker, K., & Schwarz, P. M. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.030 · Cited by 705

Regulation of the expression of inducible nitric oxide synthase

Pautz, A., Art, J., Hahn, S., Nowag, S., Voss, C., & Kleinert, H. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.04.007 · Cited by 549

Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology

Buttgereit, F., Da Silva, J. A. P., Boers, M., Burmester, G.-R., Cutolo, M., Jacobs, J., Kirwan, J., Köhler, L., van Riel, P., Vischer, T., et al. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.8.718 · Cited by 544

Churg-Strauss syndrome

Noth, I., Strek, M. E., & Leff, A. R. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12518-4 · Cited by 527

Eosinophilic granulomatosis with polyangiitis (Churg–Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management

Groh, M., Pagnoux, C., Baldini, C., Bel, E., Bottero, P., Cottin, V., Dalhoff, K., Dunogué, B., Gross, W., Holle, J., et al. (2015) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2015.04.022 · Cited by 476

Lost productive work time costs from health conditions in the United States: results from the American Productivity Audit

Stewart, W. F., Ricci, J. A., Chee, E., & Morganstein, D. (2003) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000099999.27348.78 · Cited by 427

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

Horan, G. S., Wood, S., Ona, V., Li, D. J., Lukashev, M. E., Weinreb, P. H., Simon, K. J., Hahm, K., Allaire, N. E., Rinaldi, N. J., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200706-805oc · Cited by 420

Stress: a risk factor for serious illness

VanItallie, T. B. (2002) · Metabolism · doi:10.1053/meta.2002.33191 · Cited by 414

Manifestations of chronic disease during pregnancy

Kaaja, R. J. (2005) · JAMA · doi:10.1001/jama.294.21.2751 · Cited by 382

Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome

Mazodier, K. (2005) · Blood · doi:10.1182/blood-2005-05-1980 · Cited by 290

Validity of the work productivity and activity impairment questionnaire—general health version in patients with rheumatoid arthritis

Zhang, W., Bansback, N., Boonen, A., Young, A., Singh, A., & Anis, A. H. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3141 · Cited by 287

Repetitive mechanical stretching modulates IL-1β induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts

Yang, G., Im, H.-J., & Wang, J. H.-C. (2005) · Gene · doi:10.1016/j.gene.2005.08.006 · Cited by 282

Interleukin-18, more than a Th1 cytokine

Novick, D., Kim, S., Kaplanski, G., & Dinarello, C. A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.014 · Cited by 280

Central changes associated with chronic pelvic pain and endometriosis

Brawn, J., Morotti, M., Zondervan, K. T., Becker, C. M., & Vincent, K. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu025 · Cited by 274

Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being

Elenkov, I. J. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.037 · Cited by 273

Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis

Abramson, S. B., Attur, M., Amin, A. R., & Clancy, R. (2001) · Current Rheumatology Reports · doi:10.1007/s11926-001-0069-3 · Cited by 261

Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis

Shimizu, M., Yokoyama, T., Yamada, K., Kaneda, H., Wada, H., Wada, T., Toma, T., Ohta, K., Kasahara, Y., & Yachie, A. (2010) · Rheumatology · doi:10.1093/rheumatology/keq133 · Cited by 255

Metabolic stress-induced joint inflammation and osteoarthritis

Courties, A., Gualillo, O., Berenbaum, F., & Sellam, J. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.05.016 · Cited by 249

Increased Expression of Integrin αvβ3 Contributes to the Establishment of Autocrine TGF-β Signaling in Scleroderma Fibroblasts

Asano, Y., Ihn, H., Yamane, K., Jinnin, M., Mimura, Y., & Tamaki, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7708 · Cited by 231

Affective disturbance in rheumatoid arthritis: Psychological and disease-related pathways

Sturgeon, J. A., Finan, P. H., & Zautra, A. J. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.112 · Cited by 232

Regional analysis of p53 mutations in rheumatoid arthritis synovium

Yamanishi, Y., Boyle, D. L., Rosengren, S., Green, D. R., Zvaifler, N. J., & Firestein, G. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152333199 · Cited by 214

Inadequately low serum levels of steroid hormones in relation to interleukin‐6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis

Straub, R. H., Paimela, L., Peltomaa, R., Schölmerich, J., & Leirisalo‐Repo, M. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10177 · Cited by 183

Toward quantifying the usage costs of human immunity: Altered metabolic rates and hormone levels during acute immune activation in men

Muehlenbein, M. P., Hirschtick, J. L., Bonner, J. Z., & Swartz, A. M. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21045 · Cited by 178

Molecular and cellular basis of rheumatoid joint destruction

Karouzakis, E., Neidhart, M., Gay, R. E., & Gay, S. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.04.011 · Cited by 167

Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections

Drago-Serrano, M., Campos-Rodríguez, R., Carrero, J., & De la Garza, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030501 · Cited by 151

Sodium in the microenvironment regulates immune responses and tissue homeostasis

Müller, D. N., Wilck, N., Haase, S., Kleinewietfeld, M., & Linker, R. A. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0113-4 · Cited by 149

Arthritis burden and impact are greater among U.S. women than men: intervention opportunities

Theis, K. A., Helmick, C. G., & Hootman, J. M. (2007) · Journal of Women's Health · doi:10.1089/jwh.2007.371 · Cited by 143

Skin disease: a cardinal feature of systemic sclerosis

Krieg, T., & Takehara, K. (2006) · Rheumatology · doi:10.1093/rheumatology/kep108 · Cited by 135

GM-CSF Upregulated in Rheumatoid Arthritis Reverses Cognitive Impairment and Amyloidosis in Alzheimer Mice

Boyd, T. D., Bennett, S. P., Mori, T., Governatori, N., Runfeldt, M., Norden, M., Padmanabhan, J., Neame, P., Wefes, I., Sanchez-Ramos, J., et al. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091471 · Cited by 128

The NR4A subfamily of nuclear receptors: Potential new therapeutic targets for the treatment of inflammatory diseases

Rodríguez-Calvo, R., Tajes, M., & Vázquez-Carrera, M. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1279146 · Cited by 117

The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis

Reich, N., Maurer, B., Akhmetshina, A., Venalis, P., Dees, C., Zerr, P., Palumbo, K., Zwerina, J., Nevskaya, T., Gay, S., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.25056 · Cited by 112

Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis.

Herrak, P., Görtz, B., Hayer, S., Redlich, K., Reiter, E., Gasser, J., Bergmeister, H., Kollias, G., Smolen, J. S., & Schett, G. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20384 · Cited by 110

A systematic review of the effects of dynamic exercise in rheumatoid arthritis

Cairns, A. P., & McVeigh, J. G. (2009) · Rheumatology International · doi:10.1007/s00296-009-1090-5 · Cited by 96

The genetics of macrophage activation syndrome

Schulert, G. S., & Cron, R. Q. (2020) · Genes & Immunity · doi:10.1038/s41435-020-0098-4 · Cited by 91

Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis

Stifano, G., Affandi, A. J., Mathes, A. L., Rice, L. M., Nakerakanti, S., Nazari, B., Lee, J., Christmann, R. B., & Lafyatis, R. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4598 · Cited by 86

Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics

Gill, K. L., Machavaram, K. K., Rose, R. H., & Chetty, M. (2016) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0361-4 · Cited by 82

Hormone replacement therapy in morphine-induced hypogonadic male chronic pain patients

Aloisi, A., Ceccarelli, I., Carlucci, M., Suman, A., Sindaco, G., Mameli, S., Paci, V., Ravaioli, L., Passavanti, G., Bachiocco, V., et al. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-26 · Cited by 77

Treatment with abatacept prevents experimental dermal fibrosis and induces regression of established inflammation-driven fibrosis

Ponsoye, M., Frantz, C., Ruzehaji, N., Nicco, C., Elhai, M., Ruiz, B., Cauvet, A., Pezet, S., Brandely, M. L., Batteux, F., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-208213 · Cited by 70

Cost assessment of health interventions and diseases

Fautrel, B., Boonen, A., de Wit, M., Grimm, S., Joore, M., & Guillemin, F. (2020) · RMD Open · doi:10.1136/rmdopen-2020-001287 · Cited by 63

Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies

Dunn, S. L., Wilkinson, J. M., Crawford, A., Bunning, R. A. D., & Le Maitre, C. L. (2016) · Cannabis and Cannabinoid Research · doi:10.1089/can.2015.0001 · Cited by 62

Churg-Strauss syndrome: update on recent developments

Gross, W. L. (2002) · Current Opinion in Rheumatology · doi:10.1097/00002281-200201000-00003 · Cited by 60

Intra-articular glucocorticoid injections and their effect on hypothalamic-pituitary-adrenal (hpa)-axis function

Johnston, P. C., Lansang, M. C., Chatterjee, S., & Kennedy, L. (2015) · Endocrine · doi:10.1007/s12020-014-0409-5 · Cited by 58

Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune‐mediated arthritis

Imhof, A., Glück, L., Gajda, M., Lupp, A., Bräuer, R., Schaible, H., & Schulz, S. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30410 · Cited by 52

Insulin Signaling in Arthritis

Tripolino, C., Ciaffi, J., Pucino, V., Ruscitti, P., van Leeuwen, N., Borghi, C., Giacomelli, R., Meliconi, R., & Ursini, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.672519 · Cited by 46

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes

Dunn, S. L., Wilkinson, J. M., Crawford, A., Le Maitre, C. L., & Bunning, R. A. D. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.10.016 · Cited by 46

Diurnal production of cortisol and prediction of treatment response in rheumatoid arthritis: a 6-month, real-life prospective cohort study

Yavropoulou, M. P., Filippa, M. G., Vlachogiannis, N. I., Fragoulis, G. E., Laskari, K., Mantzou, A., Panopoulos, S., Fanouriakis, A., Bournia, V.-K., Evangelatos, G., et al. (2024) · RMD Open · doi:10.1136/rmdopen-2023-003575 · Cited by 13