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Cited by 18Child and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual OffendingNeurotransmitter Receptor Influence on Behavior

The interaction between monoamine oxidase A and punitive discipline in the development of antisocial behavior: Mediation by maladaptive social information processing

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Galán, Chardée A., Choe, Daniel Ewon, Forbes, Erika E., Shaw, Daniel S.·2017·Development and Psychopathology
DOI 10.1017/s0954579416001279PMC PMC11341723
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Abstract

Previous studies demonstrate that boys' monoamine oxidase A (MAOA) genotype interacts with adverse rearing environments in early childhood, including punitive discipline, to predict later antisocial behavior. Yet the mechanisms by which MAOA and punitive parenting interact during childhood to amplify risk for antisocial behavior are not well understood. In the present study, hostile attributional bias and aggressive response generation during middle childhood, salient aspects of maladaptive social information processing, were tested as possible mediators of this relation in a sample of 187 low-income men followed prospectively from infancy into early adulthood. Given racial–ethnic variation in MAOA allele frequencies, analyses were conducted separately by race. In both African American and Caucasian men, those with the low-activity MAOA allele who experienced more punitive discipline at age 1.5 generated more aggressive responses to perceived threat at age 10 relative to men with the high-activity variant. In the African American subsample only, formal mediation analyses indicated a marginally significant indirect effect of maternal punitiveness on adult arrest records via aggressive response generation in middle childhood. The findings suggest that maladaptive social information processing may be an important mechanism underlying the association between MAOA× Parenting interactions and antisocial behavior in early adulthood. The present study extends previous work in the field by demonstrating that MAOA and harsh parenting assessed in early childhood interact to not only predict antisocial behavior in early adulthood, but also predict social information processing, a well-established social–cognitive correlate of antisocial behavior.

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  • There was a gene-environment interaction: in African American and Caucasian, 2,3,5 R + increased maternal punitive discipline at age 1.5 led to increased aggression at age 10 (p < 0.001).

    “GxE: African American and Caucasian: 2,3,5 R + increased maternal punitive discipline at age 1.5 -> inrceased aggression at age 10 (p < 0.001)”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as Galán [55]

    The Results section (“Main effects and statistical interactions with ARG”; page unavailable) reports that, in both African American and Caucasian men, maternal punitiveness in toddlerhood predicted more aggressive response generation in middle childhood only among those with low-activity MAOA. But the measured outcome was responses to perceived threat, not aggression itself. The Methods (“DNA extraction and genotyping”; page unavailable) say the primary analyses compared three-repeat with four-repeat alleles and excluded two- and five-repeat carriers; the retrieved Results do not establish p < .001 for the interaction in both racial groups. (LLM, conf=0.89)

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Research works printed but not linked: 2

  1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: Author.
  2. Coie JD, & Dodge KA (1998). Aggression and antisocial behavior. In Damon W. & Eisenberg N. (Eds.), Handbook of child psychology: Social, emotional, and personality development (Vol. 3, pp. 779– 862). Toronto: Wiley.

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Authors
Galán, C. A., Choe, D. E., Forbes, E. E., & Shaw, D. S.
Affiliations
  • University of Pittsburgh (US)
  • University of California, Davis (US)
Corresponding author
Galán, Chardée A.
ORCID
Venue
Development and Psychopathology
Publisher
Cambridge University Press (CUP)
Published
2016-12-29
Volume
29
Issue
4
Pages
1235-1252
ISSN
  • 0954-5794 (ISSN-L)
  • 1469-2198
DOI
10.1017/s0954579416001279
PMC
PMC11341723
OpenAlex
W2565872145
Cited by
18
References
110
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 1
FWCI
3.57
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Development and Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute of Mental Health (R01MH050907)
  • National Institute on Drug Abuse (K05DA025630, R01DA026222)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
monoamine oxidase A, punitive discipline, harsh parenting, antisocial behavior, hostile attribution bias, gene-environment interaction, middle childhood, early adulthood, arrest records, African American men, racial and ethnic differences, low-income men
MeSH terms
Adolescent, Aggression, Alleles, Antisocial Personality Disorder, Child, Child, Preschool, Gene Frequency, Genotype, Humans, Infant, Male, Monoamine Oxidase, Parent-Child Relations, Punishment, Parenting, Young Adult, Gene-Environment Interaction

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