The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Real‐Time and High‐Resolution Bioimaging with Bright Aggregation‐Induced Emission Dots in Short‐Wave Infrared Region
Abstract
Fluorescence imaging in the spectral region beyond the conventional near‐infrared biological window (700–900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short‐wave infrared (SWIR; 900–1700 nm) imaging modality in the past decade, long‐wavelength biomedical imaging is still suboptimal owing to the unsatisfactory materials properties of SWIR fluorophores. Taking advantage of organic dots based on an aggregation‐induced emission luminogen (AIEgen), herein microscopic vasculature imaging of brain and tumor is reported in living mice in the SWIR spectral region. The long‐wavelength emission of AIE dots with certain brightness facilitates resolving brain capillaries with high spatial resolution (≈3 µm) and deep penetration (800 µm). Owning to the deep penetration depth and real‐time imaging capability, in vivo SWIR microscopic angiography exhibits superior resolution in monitoring blood–brain barrier damage in mouse brain, and visualizing enhanced permeability and retention effect in tumor sites. Furthermore, the AIE dots show good biocompatibility, and no noticeable abnormalities, inflammations or lesions are observed in the main organs of the mice. This work will inspire new insights on development of advanced SWIR techniques for biomedical imaging.
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“The electron affinity of 6,7-diphenyl-[1,2,5]thiadiazolo[3,4-g]quinoline and its analogs is slightly weaker than that of BBTD, but they possess excellent chemical stability and enhanced solubility, demonstrating significant potential for the development of NIR-II fluorophores152.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [152]
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Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery
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Metadata
- Authors
- Qi, J., Sun, C., Zebibula, A., Zhang, H., Kwok, R. T. K., Zhao, X., Xi, W., Lam, J. W. Y., Qian, J., & Tang, B. Z.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- State Key Laboratory of Modern Optical Instruments (CN)
- Sir Run Run Shaw Hospital (CN)
- Nantong University (CN)
- Interdisciplinary Institute of Neuroscience and Technology (ZIINT) Zhejiang University Hangzhou 310020 China
- Corresponding author
- Qian, Jun
- Tang, Ben Zhong
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-01-17
- Volume
- 30
- Issue
- 12
- Pages
- e1706856-e1706856
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2786965675
- Cited by
- 418
- References
- 55
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 40 · 2023: 45 · 2022: 52 · 2021: 71 · 2020: 69 · 2019: 60 · 2018: 33
- FWCI
- 21.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Natural Science Foundation of China (61275190)
- Natural Science Foundation of Zhejiang Province (LR17F050001)
- University Grants Committee (AoE/P‐03/08)
- Research Grants Council, University Grants Committee (16305015, 16308016, N‐HKUST604/14)
- Innovation and Technology Commission (ITC‐CNERC14SC01, ITCPD117‐9)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Keywords
- aggregation-induced emission, blood-brain barrier disruption, tumor angiogenesis, enhanced permeability and retention effect, deep tissue penetration, biocompatibility, in vivo imaging
- MeSH terms
- Angiography, Animals, Brain, Fluorescence, Fluorescent Dyes, Radio Waves, Mice
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