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Real‐Time and High‐Resolution Bioimaging with Bright Aggregation‐Induced Emission Dots in Short‐Wave Infrared Region
Abstract
Fluorescence imaging in the spectral region beyond the conventional near‐infrared biological window (700–900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short‐wave infrared (SWIR; 900–1700 nm) imaging modality in the past decade, long‐wavelength biomedical imaging is still suboptimal owing to the unsatisfactory materials properties of SWIR fluorophores. Taking advantage of organic dots based on an aggregation‐induced emission luminogen (AIEgen), herein microscopic vasculature imaging of brain and tumor is reported in living mice in the SWIR spectral region. The long‐wavelength emission of AIE dots with certain brightness facilitates resolving brain capillaries with high spatial resolution (≈3 µm) and deep penetration (800 µm). Owning to the deep penetration depth and real‐time imaging capability, in vivo SWIR microscopic angiography exhibits superior resolution in monitoring blood–brain barrier damage in mouse brain, and visualizing enhanced permeability and retention effect in tumor sites. Furthermore, the AIE dots show good biocompatibility, and no noticeable abnormalities, inflammations or lesions are observed in the main organs of the mice. This work will inspire new insights on development of advanced SWIR techniques for biomedical imaging.
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“The electron affinity of 6,7-diphenyl-[1,2,5]thiadiazolo[3,4-g]quinoline and its analogs is slightly weaker than that of BBTD, but they possess excellent chemical stability and enhanced solubility, demonstrating significant potential for the development of NIR-II fluorophores152.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [152]
Citations
Cites
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationPhotophysics of aromatic molecules
Sharnoff, M. (1971) · Journal of Luminescence · doi:10.1016/0022-2313(71)90011-1 · Cited by 4,492
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048
Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. S. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,746
Bioprobes Based on AIE Fluorogens
Ding, D., Li, K., Liu, B., & Tang, B. Z. (2013) · Accounts of Chemical Research · doi:10.1021/ar3003464 · Cited by 1,835
Self-citationA small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Lovell, J. F., Jin, C. S., Huynh, E., Jin, H., Kim, C., Rubinstein, J. L., Chan, W. C. W., Cao, W., Wang, L. V., & Zheng, G. (2011) · Nature Materials · doi:10.1038/nmat2986 · Cited by 1,364
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287
Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice
Pu, K., Shuhendler, A. J., Jokerst, J. V., Mei, J., Gambhir, S. S., Bao, Z., & Rao, J. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2013.302 · Cited by 1,188
Maeda, H. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.01.002 · Cited by 1,179
Direct detection of early-stage cancers using circulating tumor DNA
Phallen, J. A., Sausen, M., Adleff, V., Leal, A., Hruban, C., White, J. R., Anagnostou, V., Fiksel, J., Cristiano, S., Papp, E., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan2415 · Cited by 1,149
Polymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging
Li, K., & Liu, B. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00014e · Cited by 1,000
Multifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995
Molecular afterglow imaging with bright, biodegradable polymer nanoparticles
Miao, Q., Xie, C., Xu, Z. J., Lyu, Y., Duan, H., Liu, X., Jokerst, J. V., & Pu, K. (2017) · Nature Biotechnology · doi:10.1038/nbt.3987 · Cited by 980
Near‐Infrared Photoluminescent Polymer–Carbon Nanodots with Two‐Photon Fluorescence
Lu, S., Sui, L., Liu, J., Zhu, S., Chen, A., Jin, M., & Yang, B. J. (2017) · Advanced Materials · doi:10.1002/adma.201603443 · Cited by 842
Hemmer, E., Benayas, A., Légaré, F., & Vetrone, F. (2016) · Nanoscale Horizons · doi:10.1039/c5nh00073d · Cited by 732
Next-generation in vivo optical imaging with short-wave infrared quantum dots
Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0056 · Cited by 686
Jia, Y., Bailey, S. T., Hwang, T. S., McClintic, S. M., Gao, S. S., Pennesi, M. E., Flaxel, C. J., Lauer, A. K., Wilson, D. J., Joachim Hornegger, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500185112 · Cited by 675
Ultralong Phosphorescence of Water‐Soluble Organic Nanoparticles for In Vivo Afterglow Imaging
Zhen, X., Tao, Y., An, Z., Chen, P., Xu, C., Chen, R., Huang, W., & Pu, K. (2017) · Advanced Materials · doi:10.1002/adma.201606665 · Cited by 602
AIE Luminogens for Bioimaging and Theranostics: From Organelles to Animals
Qian, J., & Tang, B. Z. (2017) · Chem · doi:10.1016/j.chempr.2017.05.010 · Cited by 578
Self-citationRao, L., Bu, L., Xu, J., Cai, B., Yu, G., Yu, X., He, Z., Huang, Q., Li, A., Guo, S., et al. (2015) · Small · doi:10.1002/smll.201502388 · Cited by 526
Self-citationLiang, C., Diao, S., Wang, C., Gong, H., Liu, T., Hong, G., Shi, X., Dai, H., & Liu, Z. (2014) · Advanced Materials · doi:10.1002/adma.201401825 · Cited by 502
Meta-analysis of cellular toxicity for cadmium-containing quantum dots
Oh, E., Liu, R., Nel, A., Gemill, K. B., Bilal, M., Cohen, Y., & Medintz, I. L. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2015.338 · Cited by 502
Gu, Z., Yan, L., Tian, G., Li, S., Chai, Z., & Zhao, Y. (2013) · Advanced Materials · doi:10.1002/adma.201301197 · Cited by 492
Statins: new American guidelines for prevention of cardiovascular disease
Ridker, P. M., & Cook, N. R. (2013) · The Lancet · doi:10.1016/s0140-6736(13)62388-0 · Cited by 477
Rational Design of Molecular Fluorophores for Biological Imaging in the NIR‐II Window
Yang, Q., Ma, Z., Wang, H., Zhou, B., Zhu, S., Zhong, Y., Wang, J., Wan, H., Antaris, A., Ma, R., et al. (2017) · Advanced Materials · doi:10.1002/adma.201605497 · Cited by 467
Wu, W., Mao, D., Hu, F., Xu, S., Chen, C., Zhang, C., Cheng, X., Yuan, Y., Ding, D., Kong, D., et al. (2017) · Advanced Materials · doi:10.1002/adma.201700548 · Cited by 463
Aqueous Based Semiconductor Nanocrystals
Jing, L., Kershaw, S. V., Li, Y., Huang, X., Li, Y., Rogach, A. L., & Gao, M. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00041 · Cited by 458
Ai, X., Ho, C. J. H., Aw, J., Attia, A. B. E., Mu, J., Wang, Y., Wang, X., Wang, Y., Liu, X., Chen, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms10432 · Cited by 432
Shao, W., Chen, G., Kuzmin, A., Kutscher, H. L., Pliss, A., Ohulchanskyy, T. Y., & Prasad, P. N. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b08973 · Cited by 386
Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer
Sun, Y., Qu, C., Chen, H., He, M., Tang, C. C., Shou, K., Hong, S., Yang, M., Jiang, Y., Ding, B., et al. (2016) · Chemical Science · doi:10.1039/c6sc01561a · Cited by 293
Cheng, L., He, W., Gong, H., Wang, C., Chen, Q., Cheng, Z., & Liu, Z. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201301045 · Cited by 280
Loud, P. A., Katz, D. S., Bruce, D., Klippenstein, D. L., & GROSSMAN, Z. D. (2001) · Radiology · doi:10.1148/radiology.219.2.r01ma26498 · Cited by 262
Lv, G., Guo, W., Zhang, W., Zhang, T., Li, S., Chen, S., Eltahan, A. S., Wang, D., Wang, Y., Zhang, J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b05419 · Cited by 256
Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy
Barretto, R. P. J., Ko, T. H., Jung, J. C., Wang, T. J., Capps, G., Waters, A. C., Ziv, Y., Attardo, A., Recht, L. D., & Schnitzer, M. J. (2011) · Nature Medicine · doi:10.1038/nm.2292 · Cited by 253
Clinical imaging in regenerative medicine
Naumova, A. V., Modo, M., Moore, A. V., Murry, C. E., & Frank, J. A. (2014) · Nature Biotechnology · doi:10.1038/nbt.2993 · Cited by 249
Qi, J., Fang, Y., Kwok, R. T. K., Zhang, X., Hu, X., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2017) · ACS Nano · doi:10.1021/acsnano.7b03062 · Cited by 247
Self-citationMultiscale Humidity Visualization by Environmentally Sensitive Fluorescent Molecular Rotors
Cheng, Y., Wang, J., Qiu, Z., Zheng, X., Leung, N. L. C., Lam, J. W. Y., & Tang, B. Z. (2017) · Advanced Materials · doi:10.1002/adma.201703900 · Cited by 247
Self-citationMa, Y., Tong, S., Bao, G., Gao, C., & Dai, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.007 · Cited by 241
Du, X., Qi, J., Zhang, Z., Ma, D., & Wang, Z. Y. (2012) · Chemistry of Materials · doi:10.1021/cm3008733 · Cited by 238
Self-citationNear-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
He, X., Gao, J., Gambhir, S. S., & Cheng, Z. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.08.006 · Cited by 229
Qin, W., Li, K., Feng, G., Li, M., Yang, Z., Liu, B., & Tang, B. Z. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201302114 · Cited by 227
Self-citationGd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor
Liu, Y., Chen, C., Qian, P., Lu, X., Sun, B., Zhang, X., Wang, L., Gao, X., Han, L., Chen, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms6988 · Cited by 205
Self-citationHan, X., Bai, Q., Yao, L., Liu, H., Gao, Y. P., Li, J., Liu, L., Liu, Y., Li, X., Lü, P., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201503344 · Cited by 204
Near-Infrared Upconversion Controls Photocaged Cell Adhesion
Li, W., Wang, J., Ren, J., & Qu, X. (2014) · Journal of the American Chemical Society · doi:10.1021/ja412364m · Cited by 201
Li, D., Qin, W., Xu, B., Qian, J., & Tang, B. Z. (2017) · Advanced Materials · doi:10.1002/adma.201703643 · Cited by 175
Self-citationLi, C., Li, F., Zhang, Y., Zhang, W., Zhang, X., & Wang, Q. (2015) · ACS Nano · doi:10.1021/acsnano.5b05503 · Cited by 174
Li, C., Zhang, Y., Chen, G., Hu, F., Zhao, K., & Wang, Q. (2017) · Advanced Materials · doi:10.1002/adma.201605754 · Cited by 134
Qian, G., Zhong, Z., Luo, M., Yu, D., Zhang, Z., Ma, D., & Wang, Z. Y. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp809568a · Cited by 126
Sage, J. I., Uitert, R. L. V., & Duffy, T. E. (1984) · Stroke · doi:10.1161/01.str.15.1.46 · Cited by 98
Cai, X., Bandla, A., Mao, D., Feng, G., Qin, W., Liao, L., Thakor, N. V., Tang, B. Z., & Liu, B. (2016) · Advanced Materials · doi:10.1002/adma.201601191 · Cited by 90
Self-citationQian, G., Qi, J., Davey, J. A., Wright, J. S., & Wang, Z. Y. (2012) · Chemistry of Materials · doi:10.1021/cm300938s · Cited by 89
Self-citationWang, Y., Han, X., Wang, X., Li, J., Roe, A. W., Lü, P., & Qian, J. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700685 · Cited by 73
Self-citationCarotid artery wall thickness: comparison between sonography and multi-detector row CT angiography
Saba, L., Sanfilippo, R., Montisci, R., & Mallarini, G. (2009) · Neuroradiology · doi:10.1007/s00234-009-0589-5 · Cited by 47
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Metadata
- Authors
- Qi, J., Sun, C., Zebibula, A., Zhang, H., Kwok, R. T. K., Zhao, X., Xi, W., Lam, J. W. Y., Qian, J., & Tang, B. Z.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- State Key Laboratory of Modern Optical Instruments (CN)
- Sir Run Run Shaw Hospital (CN)
- Nantong University (CN)
- Interdisciplinary Institute of Neuroscience and Technology (ZIINT) Zhejiang University Hangzhou 310020 China
- Corresponding author
- Qian, Jun
- Tang, Ben Zhong
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-01-17
- Volume
- 30
- Issue
- 12
- Pages
- e1706856-e1706856
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2786965675
- Cited by
- 418
- References
- 55
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 40 · 2023: 45 · 2022: 52 · 2021: 71 · 2020: 69 · 2019: 60 · 2018: 33
- FWCI
- 21.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Natural Science Foundation of China (61275190)
- Natural Science Foundation of Zhejiang Province (LR17F050001)
- University Grants Committee (AoE/P‐03/08)
- Research Grants Council, University Grants Committee (16305015, 16308016, N‐HKUST604/14)
- Innovation and Technology Commission (ITC‐CNERC14SC01, ITCPD117‐9)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Keywords
- aggregation-induced emission, blood-brain barrier disruption, tumor angiogenesis, enhanced permeability and retention effect, deep tissue penetration, biocompatibility, in vivo imaging
- MeSH terms
- Angiography, Animals, Brain, Fluorescence, Fluorescent Dyes, Radio Waves, Mice
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