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Real‐Time and High‐Resolution Bioimaging with Bright Aggregation‐Induced Emission Dots in Short‐Wave Infrared Region
Abstract
Fluorescence imaging in the spectral region beyond the conventional near‐infrared biological window (700–900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short‐wave infrared (SWIR; 900–1700 nm) imaging modality in the past decade, long‐wavelength biomedical imaging is still suboptimal owing to the unsatisfactory materials properties of SWIR fluorophores. Taking advantage of organic dots based on an aggregation‐induced emission luminogen (AIEgen), herein microscopic vasculature imaging of brain and tumor is reported in living mice in the SWIR spectral region. The long‐wavelength emission of AIE dots with certain brightness facilitates resolving brain capillaries with high spatial resolution (≈3 µm) and deep penetration (800 µm). Owning to the deep penetration depth and real‐time imaging capability, in vivo SWIR microscopic angiography exhibits superior resolution in monitoring blood–brain barrier damage in mouse brain, and visualizing enhanced permeability and retention effect in tumor sites. Furthermore, the AIE dots show good biocompatibility, and no noticeable abnormalities, inflammations or lesions are observed in the main organs of the mice. This work will inspire new insights on development of advanced SWIR techniques for biomedical imaging.
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“The electron affinity of 6,7-diphenyl-[1,2,5]thiadiazolo[3,4-g]quinoline and its analogs is slightly weaker than that of BBTD, but they possess excellent chemical stability and enhanced solubility, demonstrating significant potential for the development of NIR-II fluorophores152.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [152]
Citations
Cites
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationPhotophysics of aromatic molecules
Sharnoff, M. (1971) · Journal of Luminescence · doi:10.1016/0022-2313(71)90011-1 · Cited by 4,492
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048
Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. S. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,746
Bioprobes Based on AIE Fluorogens
Ding, D., Li, K., Liu, B., & Tang, B. Z. (2013) · Accounts of Chemical Research · doi:10.1021/ar3003464 · Cited by 1,835
Self-citationA small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Lovell, J. F., Jin, C. S., Huynh, E., Jin, H., Kim, C., Rubinstein, J. L., Chan, W. C. W., Cao, W., Wang, L. V., & Zheng, G. (2011) · Nature Materials · doi:10.1038/nmat2986 · Cited by 1,364
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287
Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice
Pu, K., Shuhendler, A. J., Jokerst, J. V., Mei, J., Gambhir, S. S., Bao, Z., & Rao, J. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2013.302 · Cited by 1,188
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Li, J., & Pu, K. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00001h · Cited by 1,169
Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery
Zhu, S., Tian, R., Antaris, A. L., Chen, X. S., & Dai, H. (2019) · Advanced Materials · doi:10.1002/adma.201900321 · Cited by 976
Recent Advances of Optical Imaging in the Second Near‐Infrared Window
Kenry, K., Duan, Y., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201802394 · Cited by 823
Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications
Cai, X., & Liu, B. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000845 · Cited by 796
Design of superior phototheranostic agents guided by Jablonski diagrams
Feng, G., Zhang, G., & Ding, D. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00671h · Cited by 809
Supramolecular materials based on AIE luminogens (AIEgens): construction and applications
Li, J., Wang, J., Li, H., Song, N., Wang, D., & Tang, B. Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00495e · Cited by 741
Self-citationMolecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection
Lei, Z., & Zhang, F. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202007040 · Cited by 699
J -Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm
Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10043 · Cited by 582
Self-citationRotation Restricted Emission and Antenna Effect in Single Metal–Organic Frameworks
Yin, H., Wang, X., & Yin, X. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b06755 · Cited by 576
In vivo NIR-II fluorescence imaging for biology and medicine
Wang, F., Zhong, Y., Bruns, O., Liang, Y., & Dai, H. (2024) · Nature Photonics · doi:10.1038/s41566-024-01391-5 · Cited by 564
Liu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 547
Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
Ding, F., Zhan, Y., Lu, X., & Sun, Y. (2018) · Chemical Science · doi:10.1039/c8sc01153b · Cited by 548
Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
Wang, S., Fan, Y., Li, D., Sun, C., Lei, Z., Lu, L., Wang, T., & Zhang, F. (2019) · Nature Communications · doi:10.1038/s41467-019-09043-x · Cited by 510
Self-citationNIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer
Wang, P., Fan, Y., Lu, L., Liu, L., Fan, L., Zhao, M., Xie, Y., Xu, C., & Zhang, F. (2018) · Nature Communications · doi:10.1038/s41467-018-05113-8 · Cited by 457
Atomic‐Precision Gold Clusters for NIR‐II Imaging
Liu, H., Hong, G., Luo, Z., Chen, J., Chang, J., Gong, M., He, H., Jiang, Y., Yuan, X. F., Li, L., et al. (2019) · Advanced Materials · doi:10.1002/adma.201901015 · Cited by 451
Li, Y., Cai, Z., Liu, S., Zhang, H., Wong, S. T. H., Lam, J. W. Y., Kwok, R. T. K., Qian, J., & Tang, B. Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15095-1 · Cited by 464
Self-citationCheng, H.-B., Li, Y., Tang, B. Z., & Yoon, J. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00326f · Cited by 393
Self-citationPerfecting and extending the near-infrared imaging window
Feng, Z., Tang, T., Wu, T., Yu, X., Zhang, Y., Wang, M., Zheng, J., Ying, Y., Chen, S., Zhou, J., et al. (2021) · Light: Science & Applications · doi:10.1038/s41377-021-00628-0 · Cited by 394
Self-citationAggregation-Induced Emission (AIE), Life and Health
Wang, H., Li, Q., Alam, P., Bai, H., Bhalla, V., Bryce, M. R., Cao, M., Chen, C., Chen, S., Chen, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03925 · Cited by 404
Self-citationOrganic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
Li, B., Zhao, M., Feng, L., Dou, C., Ding, S., Zhou, G., Lu, L., Zhang, H., Chen, F., Li, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16924-z · Cited by 374
Self-citationWang, Q., Dai, Y., Xu, J., Cai, J., Niu, X., Zhang, L., Chen, R., Shen, Q., Huang, W., & Fan, Q. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901480 · Cited by 371
Zhu, S., Hu, Z., Tian, R., Yung, B. C., Yang, Q., Zhao, S., Kiesewetter, D. O., Niu, G., Sun, H., Antaris, A. L., et al. (2018) · Advanced Materials · doi:10.1002/adma.201802546 · Cited by 355
Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine
Zhu, C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2018) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00600 · Cited by 348
Self-citationNIR-II light in clinical oncology: opportunities and challenges
Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q. Y., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 397
The Chemistry of Organic Contrast Agents in the NIR‐II Window
Mu, J., Xiao, M. W., Shi, Y., Geng, X., Li, H., Yin, Y., & Chen, X. S. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202114722 · Cited by 322
Yang, Y., Fan, X., Li, L., Yang, Y., Alifu, N., Xue, D., He, C., Qian, J., Hu, Q., Chen, H., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c00043 · Cited by 308
Self-citationNear-Infrared-II (NIR-II) Bioimaging via Off-Peak NIR-I Fluorescence Emission
Zhu, S., Yung, B. C., Chandra, S., Niu, G., Antaris, A. L., & Chen, X. S. (2018) · Theranostics · doi:10.7150/thno.27995 · Cited by 307
Gathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284
Self-citationStructural and process controls of AIEgens for NIR-II theranostics
Liu, S., Li, Y., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2020) · Chemical Science · doi:10.1039/d0sc02911d · Cited by 280
Self-citationNIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274
Self-citationAggregation‐Induced Dual‐Phosphorescence from Organic Molecules for Nondoped Light‐Emitting Diodes
Wang, T., Su, X., Zhang, X., Nie, X., Huang, L., Zhang, X., Sun, X., Luo, Y., & Zhang, G. (2019) · Advanced Materials · doi:10.1002/adma.201904273 · Cited by 276
Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics
Tian, R., Zeng, Q., Zhu, S., Lau, J., Chandra, S., Ertsey, R. D., Hettie, K. S., Teraphongphom, N. T., Hu, Z., Niu, G., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw0672 · Cited by 271
Multiplexed NIR‐II Probes for Lymph Node‐Invaded Cancer Detection and Imaging‐Guided Surgery
Tian, R., Ma, H., Zhu, S., Lau, J., Ma, R., Liu, Y., Lin, L., Chandra, S., Wang, S., Zhu, X., et al. (2020) · Advanced Materials · doi:10.1002/adma.201907365 · Cited by 269
Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging
Liu, S., Chen, C., Li, Y., Zhang, H., Liu, J., Wang, R., Wong, S. T. H., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201908125 · Cited by 267
Self-citationWang, S., Liu, L., Fan, Y., El‐Toni, A. M., Alhoshan, M. S., li, D., & Zhang, F. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b05148 · Cited by 252
NIR-II bioimaging of small organic molecule
Su, Y., Yu, B., Wang, S., Cong, H., & Shen, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120717 · Cited by 251
Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging
Lin, J., Zeng, X., Xiao, Y., Tang, L., Nong, J., Liu, Y., Zhou, H., Ding, B., Xu, F., Tong, H., et al. (2018) · Chemical Science · doi:10.1039/c8sc04363a · Cited by 242
Zhang, Z., Fang, X., Liu, Z., Liu, H., Chen, D., He, S., Zheng, J., Yang, B., Qin, W., Zhang, X., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201914397 · Cited by 242
Alifu, N., Zebibula, A., Qi, J., Zhang, H., Sun, C., Yu, X., Xue, D., Lam, J. W. Y., Li, G., Qian, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b05937 · Cited by 237
Self-citationLi, Y., Zeng, S., & Hao, J. (2019) · ACS Nano · doi:10.1021/acsnano.8b05431 · Cited by 228
Qi, J., Sun, C., Li, D., Zhang, H., Yu, W., Zebibula, A., Lam, J. W. Y., Xi, W., Zhu, L., Cai, F., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02452 · Cited by 226
Self-citationGuo, B., Feng, Z., Hu, D., Xu, S., Middha, E., Pan, Y., Liu, C., Zheng, H., Qian, J., Sheng, Z., et al. (2019) · Advanced Materials · doi:10.1002/adma.201902504 · Cited by 226
Self-citationAIE luminogens as fluorescent bioprobes
Niu, G., Zhang, R., Shi, X., Park, H., Xie, S., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.115769 · Cited by 226
Self-citationFeng, Z., Yu, X., Jiang, M., Zhu, L. J., Zhang, Y., Yang, W., Wang, X., Li, G., & Qian, J. (2019) · Theranostics · doi:10.7150/thno.31332 · Cited by 213
Self-citationRational Design of Near-Infrared-II Organic Molecular Dyes for Bioimaging and Biosensing
Li, B., Zhao, M., & Zhang, F. (2020) · ACS Materials Letters · doi:10.1021/acsmaterialslett.0c00157 · Cited by 207
Tang, Y., Li, Y., Hu, X., Zhao, H., Ji, Y., Chen, L., Hu, W., Zhang, W., Li, X., Lü, X., et al. (2018) · Advanced Materials · doi:10.1002/adma.201801140 · Cited by 203
Yan, D., Wang, M., Wu, Q., Niu, N., Li, M., Song, R., Rao, J., Kang, M., Zhang, Z., Zhou, F., et al. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202202614 · Cited by 187
Self-citationAcceptor engineering for NIR-II dyes with high photochemical and biomedical performance
Ji, A., Lou, H., Qu, C., Lu, W., Hao, Y., Li, J., Wu, Y., Chang, T., Chen, H., & Cheng, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-31521-y · Cited by 183
Brightness of fluorescent organic nanomaterials
Ashoka, A. H., Aparin, I. O., Reisch, A., & Klymchenko, A. S. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00464j · Cited by 180
Recent advances in the development of NIR-II organic emitters for biomedicine
Li, J., Liu, Y., Xu, Y., Li, L., Sun, Y., & Huang, W. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213318 · Cited by 174
Zhu, D., Duo, Y., Suo, M., Zhao, Y., Xia, L., Zheng, Z., Yang, L., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003672 · Cited by 164
Self-citationSun, Y. M., Ding, F., Chen, Z., Zhang, R., Li, C., Xu, Y., Zhang, Y., Ni, R., Li, X., Yang, G., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908761116 · Cited by 163
Wang, J., Liu, Y., Morsch, M., Lu, Y., Shangguan, P., Han, L., Wang, Z., Chen, X., Song, C., Liu, S., et al. (2022) · Advanced Materials · doi:10.1002/adma.202106082 · Cited by 163
Self-citationNear‐Infrared‐II Quantum Dots for In Vivo Imaging and Cancer Therapy
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Zhang, R., Xu, Y., Zhang, Y., Kim, H. S., Sharma, A. K., Gao, J., Yang, G., Kim, J. S., & Sun, Y. (2019) · Chemical Science · doi:10.1039/c9sc03504d · Cited by 158
Ding, F., Fan, Y., Sun, Y., & Zhang, F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900260 · Cited by 158
Tian, R., Ma, H., Yang, Q., Wan, H., Zhu, S., Chandra, S., Sun, H., Kiesewetter, D. O., Niu, G., Liang, Y., et al. (2018) · Chemical Science · doi:10.1039/c8sc03751e · Cited by 151
Chang, B., Chen, J., Bao, J., Sun, T., & Cheng, Z. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00401 · Cited by 155
Manipulating cell fate: dynamic control of cell behaviors on functional platforms
Li, W., Yan, Z., Ren, J., & Qu, X. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00053k · Cited by 152
Renal clearable Hafnium-doped carbon dots for CT/Fluorescence imaging of orthotopic liver cancer
Su, Y., Liu, S., Guan, Y., Xie, Z., Zheng, M. J., & Jing, X. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120110 · Cited by 150
Xu, Y., Zhang, Y., Li, J., An, J., Li, C., Bai, S., Sharma, A. K., Deng, G., Kim, J. S., & Sun, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120315 · Cited by 150
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Qi, J., Chen, C., Ding, D., & Tang, B. Z. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800477 · Cited by 143
Self-citationRecent advances of AIE dots in NIR imaging and phototherapy
Zhang, R., Duan, Y., & Liu, B. (2019) · Nanoscale · doi:10.1039/c9nr06012j · Cited by 142
Zhang, L., Li, Y., Che, W., Zhu, D., Li, G., Xie, Z., Song, N., Liu, S., Tang, B. Z., Liu, X., et al. (2019) · Advanced Science · doi:10.1002/advs.201802050 · Cited by 140
Self-citationAlam, P., Climent, C., Alemany, P., & Laskar, I. R. (2019) · Journal of Photochemistry and Photobiology C Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2019.100317 · Cited by 139
Chen, J., Chen, L., Wu, Y., Fang, Y., Zeng, F., Wu, S., & Zhao, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-27233-4 · Cited by 147
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Qi, J., Li, J., Liu, R., Li, Q., Zhang, H., Lam, J. W. Y., Kwok, R. T. K., Liu, D., Ding, D., & Tang, B. Z. (2019) · Chem · doi:10.1016/j.chempr.2019.07.015 · Cited by 133
Self-citationSong, S., Wang, Y., Zhao, Y., Huang, W., Zhang, F., Zhu, S., Wu, Q., Fu, S., Tang, B. Z., & Wang, D. (2022) · Matter · doi:10.1016/j.matt.2022.06.030 · Cited by 133
Self-citationWang, Y., Zhang, Y., Wang, J., & Liang, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.004 · Cited by 132
Hu, X., Tang, Y., Hu, Y., Lu, F., Lü, X., Wang, Y., Li, J., Li, Y., Ji, Y., Wang, W., et al. (2019) · Theranostics · doi:10.7150/thno.34390 · Cited by 132
Wang, Q., Xu, J., Geng, R., Cai, J., Li, J., Xie, C., Tang, W., Shen, Q., Huang, W., & Fan, Q. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119671 · Cited by 131
Liu, S., Chen, R., Zhang, J., Li, Y., He, M., Fan, X., Zhang, H., Lu, X., Kwok, R. T. K., Lin, H., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c07527 · Cited by 129
Self-citationWang, Q., Xia, B., Xu, J., Niu, X., Cai, J., Shen, Q., Wang, W., Huang, W., & Fan, Q. (2019) · Materials Chemistry Frontiers · doi:10.1039/c9qm00036d · Cited by 127
Du, J., Wang, X., Sun, S., Wu, Y., Jiang, K., Li, S., & Lin, H. (2024) · Advanced Materials · doi:10.1002/adma.202314083 · Cited by 130
Li, B., Wang, W., Zhao, L., Yan, D., Li, X., Gao, Q., Zheng, J., Zhou, S., Lai, S., Feng, Y., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c10694 · Cited by 125
Self-citationNi, J., Zhang, P., Jiang, T., Chen, Y., Su, H., Wang, D., Yu, Z., Kwok, R. T. K., Zhao, Z., Lam, J. W. Y., et al. (2018) · Advanced Materials · doi:10.1002/adma.201805220 · Cited by 127
Self-citationLiu, P., Mu, X., Zhang, X., & Ming, D. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00610 · Cited by 126
Wang, H., & Liu, G. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00674a · Cited by 124
Wu, W., Yang, Y., Yang, Y., Yang, Y., Zhang, K., Guo, L., Ge, H., Chen, X., Liu, J., & Feng, H. (2019) · Small · doi:10.1002/smll.201805549 · Cited by 122
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Ong, S. Y., Zhang, C., Dong, X., & Yao, S. Q. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202101964 · Cited by 120
Wan, H., Ma, H., Zhu, S., Wang, F., Tian, Y., Ma, R., Yang, Q., Hu, Z., Zhu, T., Wang, W., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804956 · Cited by 120
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Self-citationBrain imaging with near-infrared fluorophores
Wang, H., Mu, X., Jiang, Y., Liang, Y., Zhang, X., & Ming, D. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.11.003 · Cited by 119
Meng, L., Jiang, S., Song, M., Yan, F., Zhang, W., Xu, B., & Tian, W. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c03714 · Cited by 119
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Self-citationDifferent Strategies for Organic Nanoparticle Preparation in Biomedicine
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Ding, F., Chen, Z., Kim, W. Y., Sharma, A. K., Li, C., Ouyang, Q., Zhu, H., Yang, G., Sun, Y., & Kim, J. S. (2019) · Chemical Science · doi:10.1039/c9sc02466b · Cited by 113
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Li, Y., Wu, Q., Kang, M., Song, N., Wang, D., & Tang, B. Z. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119749 · Cited by 108
Self-citationYu, L., Feng, L., Li, X., Li, S., Xu, Q., Pan, X., & Xiao, Y. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c00134 · Cited by 106
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Metadata
- Authors
- Qi, J., Sun, C., Zebibula, A., Zhang, H., Kwok, R. T. K., Zhao, X., Xi, W., Lam, J. W. Y., Qian, J., & Tang, B. Z.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- State Key Laboratory of Modern Optical Instruments (CN)
- Sir Run Run Shaw Hospital (CN)
- Nantong University (CN)
- Interdisciplinary Institute of Neuroscience and Technology (ZIINT) Zhejiang University Hangzhou 310020 China
- Corresponding author
- Qian, Jun
- Tang, Ben Zhong
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-01-17
- Volume
- 30
- Issue
- 12
- Pages
- e1706856-e1706856
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2786965675
- Cited by
- 418
- References
- 55
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 40 · 2023: 45 · 2022: 52 · 2021: 71 · 2020: 69 · 2019: 60 · 2018: 33
- FWCI
- 21.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Natural Science Foundation of China (61275190)
- Natural Science Foundation of Zhejiang Province (LR17F050001)
- University Grants Committee (AoE/P‐03/08)
- Research Grants Council, University Grants Committee (16305015, 16308016, N‐HKUST604/14)
- Innovation and Technology Commission (ITC‐CNERC14SC01, ITCPD117‐9)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Keywords
- aggregation-induced emission, blood-brain barrier disruption, tumor angiogenesis, enhanced permeability and retention effect, deep tissue penetration, biocompatibility, in vivo imaging
- MeSH terms
- Angiography, Animals, Brain, Fluorescence, Fluorescent Dyes, Radio Waves, Mice
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