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Global estimates on the number of persons across the Alzheimer's disease continuum
Open accessAbstract
Introduction: Global estimates on numbers of persons in early stages of Alzheimer's disease (AD), including prodromal and preclinical, are lacking, yet are needed to inform policy decisions on preventive measures and planning for future therapies targeting AD pathology. Methods: We synthesized the literature on prevalence across the AD continuum and derived a model estimating the number of persons, stratified by 5‐year age groups, sex, and disease stage (AD dementia, prodromal AD, and preclinical AD). Results: The global number of persons with AD dementia, prodromal AD, and preclinical AD were estimated at 32, 69, and 315 million, respectively. Together they constituted 416 million across the AD continuum, or 22% of all persons aged 50 and above. Discussion: Considering predementia stages, the number of persons with AD is much larger than conveyed in available literature. Our estimates are uncertain, especially for predementia stages in low‐ and middle‐income regions where biomarker studies are missing.
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“While this is still the subject of ongoing research, estimates are emerging of the prevalence of preclinical Alzheimer's disease in the population.”
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Metadata
- Authors
- Gustavsson, A., Norton, N., Fast, T., Frölich, L., Georges, J., Holzapfel, D., Kirabali, T., Krolak‐Salmon, P., Rossini, P. M., Ferretti, M. T., Lanman, L., Chadha, A. S., & van der Flier, W. M.
- Affiliations
- Karolinska Institutet (SE)
- Quantify Research (Sweden) (SE)
- Heidelberg University (DE)
- Alzheimer Europe (LU)
- CEO Initiative on Alzheimer's Disease Philadelphia USA
- Biogen (Switzerland) (CH)
- Hospices Civils de Lyon (FR)
- Università Cattolica del Sacro Cuore (IT)
- Women's Brain Project (CH)
- F. Hoffmann-La Roche AG (CH)
- Alzheimer Center Amsterdam Department of Neurology Department of Epidemiology and Data Science Amsterdam Neuroscience Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam the Netherlands
- Corresponding author
- Gustavsson, Anders
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2022-06-02
- Volume
- 19
- Issue
- 2
- Pages
- 658-670
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W4281674975
- Cited by
- 895
- References
- 62
- Citations by year
- 2026: 207 · 2025: 323 · 2024: 236 · 2023: 114 · 2022: 15
- FWCI
- 112.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- F. Hoffmann-La Roche
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, Alzheimer's disease continuum
- MeSH terms
- Alzheimer Disease, Humans, Biomarkers, Prevalence, Prodromal Symptoms
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