Cited by 236Parkinson's Disease Mechanisms and TreatmentsCoenzyme Q10 studies and effectsMitochondrial Function and Pathology

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Bioenergetic approaches for neuroprotection in Parkinson's disease

Beal, M. Flint·2003·Annals of Neurology

DOI 10.1002/ana.10479

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Abstract

There is considerable evidence suggesting that mitochondrial dysfunction and oxidative damage may play a role in the pathogenesis of Parkinson's disease (PD). This possibility has been strengthened by recent studies in animal models, which have shown that a selective inhibitor of complex I of the electron transport gene can produce an animal model that closely mimics both the biochemical and histopathological findings of PD. Several agents are available that can modulate cellular energy metabolism and that may exert antioxidative effects. There is substantial evidence that mitochondria are a major source of free radicals within the cell. These appear to be produced at both the iron-sulfur clusters of complex I as well as the ubiquinone site. Agents that have shown to be beneficial in animal models of PD include creatine, coenzyme Q(10), Ginkgo biloba, nicotinamide, and acetyl-L-carnitine. Creatine has been shown to be effective in several animal models of neurodegenerative diseases and currently is being evaluated in early stage trials in PD. Similarly, coenzyme Q(10) is also effective in animal models and has shown promising effects both in clinical trials of PD as well as in clinical trials in Huntington's disease and Friedreich's ataxia. Many other agents show good human tolerability. These agents therefore are promising candidates for further study as neuroprotective agents in PD.

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R. S., Sherer, T., MacKenzie, G. M., Garcia‐Osuna, M., Panov, A. V., & Greenamyre, J. T. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,770
Mitochondrial Complex I Deficiency in Parkinson's Disease
Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283
Superoxide activates mitochondrial uncoupling proteins
Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382
Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
Nicklas, W. J., Vyas, I. L., & Heikkila, R. E. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90146-8 · Cited by 1,273
Generation of reactive oxygen species by the mitochondrial electron transport chain
Liu, Y., Fiskum, G., & Schubert, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00744.x · Cited by 1,260
Abnormalities of the electron transport chain in idiopathic parkinson's disease
Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061
A Fraction of Yeast Cu,Zn-Superoxide Dismutase and Its Metallochaperone, CCS, Localize to the Intermembrane Space of Mitochondria
Sturtz, L. A., Diekert, K., Jensen, L. T., Lill, R., & Culotta, V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105296200 · Cited by 735
The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living
Gorell, J., Johnson, C. C., Rybicki, B., Peterson, E., & Richardson, R. (1998) · Neurology · doi:10.1212/wnl.50.5.1346 · Cited by 694
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
Klivenyi, P., Ferrante, R. J., Matthews, R. T., Bogdanov, M. B., Klein, A. M., Andreassen, O. A., Mueller, G., Wermer, M., Kaddurah-Daouk, R., & Beal, M. F. (1999) · Nature Medicine · doi:10.1038/6568 · Cited by 682
Self-citation
Experimental models of Parkinson's disease
Beal, M. F. (2001) · Nature reviews. Neuroscience · doi:10.1038/35072550 · Cited by 645
Self-citation
Origin and functional consequences of the complex I defect in Parkinson's disease
Swerdlow, R. H., Parks, J. K., Miller, S. W., Davis, R. E., Tuttle, J. B., Trimmer, P. A., Sheehan, J. P., Bennett, J. P., & Parker, W. D. (1996) · Annals of Neurology · doi:10.1002/ana.410400417 · Cited by 638
ΔΨ m ‐Dependent and ‐independent production of reactive oxygen species by rat brain mitochondria
Votyakova, T. V., & Reynolds, I. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00548.x · Cited by 601
Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8892 · Cited by 557
Self-citation
Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease
Ferrante, R. J., Andreassen, O. A., Jenkins, B. G., Dedeoglu, A., Kuemmerle, S., Kubilus, J. K., Kaddurah-Daouk, R., Hersch, S. M., & Beal, M. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04389.2000 · Cited by 522
Self-citation
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl- l -carnitine and/or R -α-lipoic acid
Liu, J., Head, E., Gharib, A., Yuan, W., Ingersoll, R. T., Hagen, T. M., Cotman, C. W., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261709299 · Cited by 504
Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease
Haas, R. H., Nasirian, F., Nakano, K., Ward, D., Pay, M., Hill, R., & Shults, C. W. (1995) · Annals of Neurology · doi:10.1002/ana.410370604 · Cited by 435
Possible environmental, occupational, and other etiologic factors for Parkinson's disease
Seidler, A., Hellenbrand, W., Robra, B., Vieregge, P., NISCHAN, P., Joerg, J., Oertel, W. H., Ulm, G., & Schneider, E. (1996) · Neurology · doi:10.1212/wnl.46.5.1275 · Cited by 431
Neuroprotective Effects of Creatine and Cyclocreatine in Animal Models of Huntington’s Disease
Matthews, R. T., Yang, L., Jenkins, B. G., Ferrante, R. J., Rosen, B. R., Kaddurah-Daouk, R. F., & Beal, M. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00156.1998 · Cited by 431
Self-citation
Energy metabolism defects in Huntington's disease and effects of coenzyme Q10
Koroshetz, W. J., Jenkins, B. G., Rosen, B. R., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410206 · Cited by 405
Self-citation
Therapeutic Effects of Coenzyme Q10and Remacemide in Transgenic Mouse Models of Huntington's Disease
Ferrante, R. J., Andreassen, O. A., Dedeoglu, A., Ferrante, K. L., Jenkins, B. G., Hersch, S. M., & Beal, M. F. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01592.2002 · Cited by 391
Self-citation
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism
Mandir, A. S., Przedborski, S., Jackson-Lewis, V., Wang, Z.-Q., Simbulan-Rosenthal, C. M., Smulson, M. E., Hoffman, B. E., Guastella, D. B., Dawson, V. L., & Dawson, T. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5774 · Cited by 382
Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity
Matthews, R. T., Ferrante, R. J., Klivènyi, P., Yang, L., Klein, A., Mueller, G., Kaddurah-Daouk, R. F., & Beal, M. F. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7049 · Cited by 374
Self-citation
Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling
Kagan, V. E., Serbinova, E. A., & Packer, L. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91971-t · Cited by 363
Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study
Rustin, P., von Kleist-Retzow, J., Chantrel-Groussard, K., Sidi, D., Münnich, A., & Rötig, A. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01341-0 · Cited by 348
Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
Shults, C. W., Haas, R. H., Passov, D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410420221 · Cited by 326
Self-citation
Parkinson's disease, pesticides, and glutathione transferase polymorphisms
Menegon, A., Philip G. Board, Blackburn, A. C., Mellick, G. D., & Couteur, D. G. L. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03453-9 · Cited by 314
Uncoupling proteins 2 and 3 are highly active H + transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)
Echtay, K. S., Winkler, E., Frischmuth, K., & Klingenberg, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1416 · Cited by 313
Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease
Gu, M., Cooper, J. A. D., Taanman, J., & Schapira, A. H. V. (1998) · Annals of Neurology · doi:10.1002/ana.410440207 · Cited by 313
Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease
Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., Jenkins, B. G., Ferrante, K. L., Thomas, M., Friedlich, A., Browne, S. E., Schilling, G., Borchelt, D. R., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0406 · Cited by 293
Self-citation
Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease
Hattori, N., Tanaka, M., Ozawa, T., & Mizuno, Y. (1991) · Annals of Neurology · doi:10.1002/ana.410300409 · Cited by 275
Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl- l - carnitine and/or R -α-lipoic acid
Liu, J., Killilea, D. W., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261709098 · Cited by 266
Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice
Beal, M. F., Matthews, R. T., Tieleman, A., & Shults, C. W. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01192-x · Cited by 256
Self-citation
Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study
Caparros-Lefebvre, D., & Elbaz, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10166-6 · Cited by 256
Acetyl- l -carnitine fed to old rats partially restores mitochondrial function and ambulatory activity
Hagen, T. M., Ingersoll, R. T., Wehr, C. M., Lykkesfeldt, J., Vinarsky, V., Bartholomew, J. C., Song, M. H., & Ames, B. N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9562 · Cited by 252
An analysis of the role of coenzyme Q in free radical generation and as an antioxidant
Beyer, R. E. (1992) · Biochemistry and Cell Biology · doi:10.1139/o92-061 · Cited by 251
Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia
HAUSSE, A., Aggoun, Y., Bonnet, D., Sidi, D., Münnich, A., Rötig, A., & Rustin, P. (2002) · Heart · doi:10.1136/heart.87.4.346 · Cited by 251
MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE
Bindoff, L. A., Birch‐Machin, M. A., Cartlidge, N. E. F., Parker, W. D., & Turnbull, D. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90291-2 · Cited by 245
Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders
Tarnopolsky, M. A., & Beal, M. F. (2001) · Annals of Neurology · doi:10.1002/ana.1028 · Cited by 244
Self-citation
The role of creatine kinase in inhibition of mitochondrial permeability transition
O’Gorman, E., Beutner, G., Dolder, M., Koretsky, A. P., Brdiczka, D. G., & Wallimann, T. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01045-4 · Cited by 243
Protective effect of the energy precursor creatine against toxicity of glutamate and β-amyloid in rat hippocampal neurons
Brewer, G. J., & Wallimann, T. W. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741968.x · Cited by 230
Regulation of ubiquinone metabolism
Dallner, G., & Sindelar, P. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00307-5 · Cited by 201
Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation
Guan, M. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.6.573 · Cited by 193
Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate
Beal, M. F., Henshaw, D. R., Jenkins, B. G., Rosen, B. R., & Schulz, J. B. (1994) · Annals of Neurology · doi:10.1002/ana.410360613 · Cited by 189
Self-citation
Mitochondrial Creatine Kinase Is a Prime Target of Peroxynitrite-induced Modification and Inactivation
Stachowiak, O., Dolder, M., Wallimann, T., & Richter, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16694 · Cited by 189
Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide
Oyama, Y., Chikahisa, L., Ueha, T., Kanemaru, K., & Noda, K. (1996) · Brain Research · doi:10.1016/0006-8993(95)01440-3 · Cited by 188
Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stress
Marangon, K., Devaraj, S., Tirosh, O., Packer, L., & Jialal, I. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00155-0 · Cited by 183
Mitochondria in Sporadic Amyotrophic Lateral Sclerosis
Swerdlow, R. H., Parks, J. K., Cassarino, D. S., Trimmer, P. A., Miller, S. W., Maguire, D., Sheehan, J. P., Maguire, R. S., Pattee, G. L., Juel, V. C., et al. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6866 · Cited by 180
A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
Krauss, S., Zhang, C., & Lowell, B. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012410699 · Cited by 176
α-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats
Panigrahi, M., Sadguna, Y., Shivakumar, B. R., Kolluri, S. V. R., Roy, S., Packer, L., & Ravindranath, V. (1996) · Brain Research · doi:10.1016/0006-8993(96)00009-1 · Cited by 176
Mitochondrial ROS Metabolism: Modulation by Uncoupling Proteins
Casteilla, L., Rigoulet, M., & Pénicaud, L. (2001) · IUBMB Life · doi:10.1080/15216540152845984 · Cited by 173
Electron Transport-Linked Ubiquinone-Dependent Recycling of α-Tocopherol Inhibits Autooxidation of Mitochondrial Membranes
Lass, A., & Sohal, R. S. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0606 · Cited by 162
A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice
Johnson, K. R., Zheng, Q. Y., Bykhovskaya, Y., Spirina, O., & Fischel‐Ghodsian, N. (2001) · Nature Genetics · doi:10.1038/84831 · Cited by 157
The reaction of nitric oxide with ubiquinol: kinetic properties and biological significance
Poderoso, J. J., Carreras, M. C., Schopfer, F. J., Lisdero, C. L., Galdo, N. A. R., Giulivi, C., Boveris, A. D., Boveris, A., & Cadenas, E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00277-9 · Cited by 156
Ginkgo biloba extract (egb 761): inhibitory effect on nitric oxide production in the macrophage cell line raw 264.7
Kobuchi, H., Droy-Lefaix, M. T., Christen, Y., & Packer, L. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00873-8 · Cited by 154
Antioxidant action of ubiquinol homologues with different isoprenoid chain length in biomembranes
Kagan, V. E., Serbinova, E. A., Koynova, G. M., Kitanova, S., Tyurin, V. A., Stoytchev, T., Quinn, P. J., & Packer, L. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90114-x · Cited by 147
Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation
Simon, D. K., Pulst, S. M., Sutton, J. P., Browne, S. E., Beal, M. F., & Johns, D. R. (1999) · Neurology · doi:10.1212/wnl.53.8.1787 · Cited by 141
Self-citation
The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition
Brdiczka, D. G., Beutner, G., Rück, A., Dolder, M., & Wallimann, T. (1998) · BioFactors · doi:10.1002/biof.5520080311 · Cited by 138
Mitochondrial creatine kinase mediates contact formation between mitochondrial membranes.
Rojo, M., Hovius, R., DEMEL, R. A., Nicolay, K., & Wallimann, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54921-8 · Cited by 134
The Cloning and Expression of a Human Creatine Transporter
Sora, I., Richman, J., Santoro, G. P., Wei, H.-B., Wang, Y., Vanderah, T. W., Horváth, R., Nguyen, M., Waite, S. L., Roeske, W. R., et al. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2475 · Cited by 132
Kinetic study of free-radical-scavenging action of biological hydroquinones (reduced forms of ubiquinone, vitamin K and tocopherol quinone) in solution
Mukai, K., Morimoto, H., Kikuchi, S., & Nagaoka, S. (1993) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(93)90115-o · Cited by 127
Lipoic acid improves survival in transgenic mouse models of Huntington's disease
Andreassen, O. A., Ferrante, R. J., Dedeoglu, A., & Beal, M. F. (2001) · Neuroreport · doi:10.1097/00001756-200110290-00044 · Cited by 115
Self-citation
Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats
Ayoub, I. A., Lee, E. J., Ogilvy, C. S., Beal, M. F., & Maynard, K. I. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00881-7 · Cited by 107
Self-citation
Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine
Guthmiller, P., Pilsum, J. F. V., Boen, J. R., & McGuire, D. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32477-8 · Cited by 106
Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson’s disease
Simon, D. K., Mayeux, R. P., Marder, K. S., Kowall, N. W., Beal, M. F., & Johns, D. R. (2000) · Neurology · doi:10.1212/wnl.54.3.703 · Cited by 106
Self-citation
Dihydrolipoic Acid Maintains Ubiquinone in the Antioxidant Active Form by Two-Electron Reduction of Ubiquinone and One-Electron Reduction of Ubisemiquinone
Kozlov, A. V., Gille, L., Staniek, K., & Nohl, H. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.1064 · Cited by 106
Cardiac energetics are abnormal in Friedreich ataxia patients in the absence of cardiac dysfunction and hypertrophy: An in vivo 31P magnetic resonance spectroscopy study
Lodi, R. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00357-1 · Cited by 104
A common mitochondrial DNA variant associated with susceptibility to dilated cardiomyopathy in two different populations
Khogali, S., Mayosi, B. M., Beattie, J. M., McKenna, W. J., Watkins, H. C., & Poulton, J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04422-6 · Cited by 104
Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity
Schulz, J. B., Ross Henshaw, D., Matthews, R. T., & Flint Beal, M. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90033-0 · Cited by 103
Self-citation
Protective actions of l-carnitine and acetyl-l-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors
Virmani, A., Biselli, R., Spadoni, A., Rossi, S., Corsico, N., Calvani, M., Fattorossi, A., Simone, C. D., & Arrigoni‐Martelli, E. (1995) · Pharmacological Research · doi:10.1016/s1043-6618(05)80044-1 · Cited by 101
Succinate-ubiquinone reductase linked recycling of α-tocopherol in reconstituted systems and mitochondria: Requirement for reduced ubiquinone
Maguire, J. J., Kagan, V. E., Ackrell, B. A. C., Serbinova, E. A., & Packer, L. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90049-3 · Cited by 95
Phosphocreatine-dependent Glutamate Uptake by Synaptic Vesicles
Xu, C. J., Klunk, W. E., Kanfer, J. N., Xiong, Q. P., Miller, G., & Pettegrew, J. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13435 · Cited by 95
Neuroprotective effects of α-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia
Wolz, P., & Krieglstein, J. (1996) · Neuropharmacology · doi:10.1016/0028-3908(95)00172-7 · Cited by 95
Altered redox state of platelet coenzyme Q 10 in Parkinson's disease
Götz, M. E., Gerstner, A., Harth, R., Dirr, A., Janetzky, B., Kuhn, W., Riederer, P., & Gerlach, M. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050003 · Cited by 93
Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): prevention by the poly(ADP-ribose) polymerase inhibitor, benzamide
Cosi, C., & Marien, M. R. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00829-4 · Cited by 86
Prolonged Pretreatment with α-Lipoic Acid Protects Cultured Neurons against Hypoxic, Glutamate-, or Iron-Induced Injury
Müller, U., & Krieglstein, J. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.77 · Cited by 84
Preincubation with Creatine Enhances Levels of Creatine Phosphate and Prevents Anoxic Damage in Rat Hippocampal Slices
Carter, A. J., MULLER, R. E., Pschorn, U., & Stransky, W. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64062691.x · Cited by 83
Protection against peroxynitrite‐dependent tyrosine nitration and α1‐antiproteinase inactivation by oxidized and reduced lipoic acid
Whiteman, M., Tritschler, H., & Halliwell, B. B. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01489-6 · Cited by 81
Relations Between Tocopherol Depletion and Coenzyme Q During Lipid Peroxidation in rat Liver Mitochondria
Noack, H., Kube, U., & Augustin, W. (1994) · Free Radical Research · doi:10.3109/10715769409145637 · Cited by 81
Therapeutic Efficacy of EGb761 (Gingko biloba Extract) in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Ferrante, R. J., Klein, A., Dedeoglu, A., & Beal, M. F. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:1:89 · Cited by 78
Self-citation
Sequence Analysis of the Entire Mitochondrial Genome in Parkinson's Disease
Vives-Bauzá, C., Andreu, A. L., Manfredi, G., Beal, M. F., Janetzky, B., Gruenewald, T. H., & Lin, M. T. S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6388 · Cited by 73
Self-citation
Effect of acetyl-l-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat — study by 13P- and 1H-NMR spectroscopy
Aureli, T., Miccheli, A., Cocco, M. E. D., Ghirardi, O., Giuliani, A., Ramacci, M. T., & Conti, F. (1994) · Brain Research · doi:10.1016/0006-8993(94)90013-2 · Cited by 67
Anoxic ATP depletion in neonatal mice brainstem is prevented by creatine supplementation
Wilken, B., Ramirez, J., Probst, I., Richter, D. W., & Hanefeld, F. A. (2000) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.82.3.f224 · Cited by 54
Serum levels of coenzyme Q10 in patients with Parkinson's disease
Jiménez‐Jiménez, F. J., Molina, J. A., de Bustos, F., García‐Redondo, A., Gómez-Escalonilla, C., Martínez‐Salio, A., Berbel, Á., Camacho, A., Zurdo, M., Barcenilla, B., et al. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050015 · Cited by 50
Effect of lipoic acid on redox state of coenzyme Q in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and diethyldithiocarbamate
Götz, M. E., Dirr, A., Burger, R., Janetzky, B., Weinmüller, M., Chan, W. W., Chen, S. C., Reichmann, H., Rausch, W., & Riederer, P. F. (1994) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(94)90139-2 · Cited by 47
Biochemical Analysis of Cybrids Expressing Mitochondrial DNA from Contursi Kindred Parkinson's Subjects
Swerdlow, R. H., Parks, J. K., Cassarino, D. S., Binder, D. R., Bennett, J. P., Iorio, G. D., Golbe, L. I., & Parker, W. D. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7674 · Cited by 43
Effect of coenzyme Q10 on biochemical and morphological changes in experimental ischemia in the rat brain
Ostrowski, R. P. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00406-8 · Cited by 37
Cytoplasmic Transfer of Platelet mtDNA from Elderly Patients with Parkinson's Disease to mtDNA-less HeLa Cells Restores Complete Mitochondrial Respiratory Function
Aomi, Y., Chen, C.-S., Nakada, K., Ito, S., Isobe, K., Murakami, H., Kuno, S., Tawata, M., Matsuoka, R., Mizusawa, H., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4113 · Cited by 35
Stabilising action of carnitine on energy linked processes in rat liver mitochondria
Lisa, F. D., Bobyleva-Guarriero, V., Jocelyn, P. C., Toninello, A., & Siliprandi, N. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91334-8 · Cited by 30
Mitochondrial superoxide anion production and release into intermembrane space
Han, D., Antunes, F., Daneri, F., & Cadenas, E. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)49341-x · Cited by 28
Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10
Brouillet, E., Henshaw, D. R., Schulz, J. B., & Beal, M. F. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90044-2 · Cited by 23 · cited 1×
“CoQ10 administration also significantly attenuated striatal lesions produced by aminoxyacetic acid.(67) The role of CoQ10 has also been studied in MPTP toxicity.”
BackgroundSelf-citation
Parkinson disease: analysis of mitochondrial DNA in monozygotic twins.
Kösel, S., Grasbon-Frodl, E. M., Hagenah, J., Graeber, M. B., & Vieregge, P. (2000) · PubMed · doi:10.1007/pl00022973 · Cited by 20
l-Carnitine delays the killing of cultured hepatocytes by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Snyder, J. W., Kyle, M. E., & Ferraro, T. N. (1990) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(90)90019-u · Cited by 17
Parkinson disease: analysis of mitochondrial DNA in monozygotic twins
Kösel, S., Grasbon-Frodl, E. M., Hagenah, J. M., Graeber, M. B., & Vieregge, P. (2000) · Neurogenetics · doi:10.1007/s100489900085 · Cited by 17
Cortical neurogenesis and its disorders
Kriegstein, A. R. (1996) · Current Opinion in Neurology · doi:10.1097/00019052-199604000-00010 · Cited by 13
Untitled work
(2000) · doi:10.1002/1531-8249(200011)48:5

Research works printed but not linked: 7

Rana, 2000, Ann Neurol, 48, 774, 10.1002/1531-8249(200011)48:5<774::AID-ANA11>3.0.CO;2-I · DOI
Brdiczka, 1994, Mol Cell Biochem, 133
Sullivan, 2000, Ann Neurol, 48, 723, 10.1002/1531-8249(200011)48:5<723::AID-ANA5>3.0.CO;2-W · DOI
Noack, 1994, Free Radic Res, 20, 375, 10.3109/10715769409145637 · DOI
2001, Neurology, 57, 397
Effect of EGb 761 on lipid peroxidation, DNA repair and antioxienzyme activity. In: eds. Advances in Ginkgo biloba extract research. Ginkgo biloba extract (EGb 761) as a free-radical scavenger. Vol 2. Paris: Elsevier, 1993: 27-38.
In vivo Ginkgo biloba extract (EGb 761) protects against neurotoxic effects induced by MPTP: investigations into its mechanism(s) of action. In: eds. Effects of Ginkgo biloba extract (EGb 761) on the central nervous system. Paris: Elsevier; 1992: 27-36.

Sorted by citations

The Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845
Mitochondria in neuroplasticity and neurological disorders
Mattson, M. P., Gleichmann, M., & Cheng, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.010 · Cited by 1,081
The scientific and clinical basis for the treatment of Parkinson disease (2009)
Olanow, C. W., Stern, M. B., & Sethi, K. D. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a1d44c · Cited by 947
Bioenergetics and the formation of mitochondrial reactive oxygen species
Ádám‐Vizi, V., & Chinopoulos, C. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.10.005 · Cited by 623
Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research
Stork, C., & Renshaw, P. F. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001711 · Cited by 489

See all 236

Authors: Beal, M. F.
Affiliations: NewYork–Presbyterian Hospital (US)
Corresponding author: Beal, M. Flint
Venue: Annals of Neurology
Publisher: Wiley
Published: 2003
Volume: 53
Issue: S3
Pages: S39-S48
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.10479
OpenAlex: W2102440831
Cited by: 236
References: 97
Citations by year: 2026: 4 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 2 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 12 · 2012: 8
FWCI: 2.59
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 4626 d)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: Parkinson's disease, neuroprotection, mitochondrial dysfunction, oxidative stress, mitochondrial complex I inhibition, electron transport chain, free radicals, iron-sulfur clusters, coenzyme Q10, creatine, Ginkgo biloba, nicotinamide, acetyl-L-carnitine, energy metabolism, antioxidants, Parkinson's disease model
MeSH terms: Acetylcarnitine, Coenzymes, Creatine, Energy Metabolism, Free Radicals, Humans, Thioctic Acid, Phytotherapy, Mitochondria, Niacinamide, Parkinson Disease, Ubiquinone, Neuroprotective Agents, Nootropic Agents, Ginkgo biloba

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Bioenergetic approaches for neuroprotection in Parkinson's disease

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