Cited by 217Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

Suprachiasmatic neuron numbers and rest–activity circadian rhythms in older humans

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Wang, Joshua L., Lim, Andrew S., Chiang, Wei‐Yin, Hsieh, Wan‐Hsin, Lo, Men‐Tzung, Schneider, Julie A., Buchman, Aron S., Bennett, David A. +2 more·2015·Annals of Neurology

Abstract

The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. We report that the circadian rhythm amplitude of motor activity in both AD subjects and age‐matched controls is correlated with the number of vasoactive intestinal peptide–expressing SCN neurons. AD was additionally associated with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathologies and strategies for treating aging‐ and AD‐related circadian disturbances. Ann Neurol 2015;78:317–322

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  • In humans and rodent models, the amplitude of peripheral oscillatory rhythms dampens with age.

    “In humans and rodent models, the amplitude of peripheral oscillatory rhythms dampens with age”
  • AD brains show marked loss of neurons in the SCN, and SCN neuronal loss correlates with reductions in the amplitude of motor activity rhythms in the same individuals before death.

    “AD brains show marked loss of neurons in the SCN243,244,262, and SCN neuronal loss correlates with reductions in the amplitude of motor activity rhythms in the same individuals before death240.”

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  1. [11]Senroy N Suryanarayanan S Ribeiro PF An Improved Hilbert–Huang Method for Analysis of Time-Varying Waveforms in Power Quality IEEE Trans Power Syst 2007 22 4 1843 1850

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Authors
Wang, J. L., Lim, A. S., Chiang, W., Hsieh, W., Lo, M., Schneider, J. A., Buchman, A. S., Bennett, D. A., Hu, K., & Saper, C. B.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • Brigham and Women's Hospital (US)
  • Rush University Medical Center (US)
Corresponding author
Saper, Clifford B.
Venue
Annals of Neurology
Publisher
Wiley
Published
2015-06-18
Volume
78
Issue
2
Pages
317-322
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2109046615
Cited by
217
References
22
Citations by year
2026: 10 · 2025: 25 · 2024: 11 · 2023: 21 · 2022: 20 · 2021: 28 · 2020: 26 · 2019: 14 · 2018: 21 · 2017: 24 · 2016: 13 · 2015: 4
FWCI
11.41
Type
journal article
Language
en
Open access
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (NS072337)
  • National Institutes of Health (AG09975, HL095491)
  • Dana Foundation
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
suprachiasmatic nucleus, circadian rhythm, Alzheimer's disease, aging, vasoactive intestinal peptide, motor activity, circadian phase, circadian rhythm amplitude, hypothalamus
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Circadian Rhythm, Female, Humans, Male, Middle Aged, Motor Activity, Neurons, Suprachiasmatic Nucleus, Vasoactive Intestinal Peptide, Case-Control Studies, Actigraphy

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