Suprachiasmatic neuron numbers and rest–activity circadian rhythms in older humans
Open accessAbstract
The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. We report that the circadian rhythm amplitude of motor activity in both AD subjects and age‐matched controls is correlated with the number of vasoactive intestinal peptide–expressing SCN neurons. AD was additionally associated with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathologies and strategies for treating aging‐ and AD‐related circadian disturbances. Ann Neurol 2015;78:317–322
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In humans and rodent models, the amplitude of peripheral oscillatory rhythms dampens with age.
“In humans and rodent models, the amplitude of peripheral oscillatory rhythms dampens with age”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [240]
AD brains show marked loss of neurons in the SCN, and SCN neuronal loss correlates with reductions in the amplitude of motor activity rhythms in the same individuals before death.
“AD brains show marked loss of neurons in the SCN243,244,262, and SCN neuronal loss correlates with reductions in the amplitude of motor activity rhythms in the same individuals before death240.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [240]
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- Authors
- Wang, J. L., Lim, A. S., Chiang, W., Hsieh, W., Lo, M., Schneider, J. A., Buchman, A. S., Bennett, D. A., Hu, K., & Saper, C. B.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Corresponding author
- Saper, Clifford B.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2015-06-18
- Volume
- 78
- Issue
- 2
- Pages
- 317-322
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC4515161
- OpenAlex
- W2109046615
- Cited by
- 217
- References
- 22
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 11 · 2023: 21 · 2022: 20 · 2021: 28 · 2020: 26 · 2019: 14 · 2018: 21 · 2017: 24 · 2016: 13 · 2015: 4
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS072337)
- National Institutes of Health (AG09975, HL095491)
- Dana Foundation
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- suprachiasmatic nucleus, circadian rhythm, Alzheimer's disease, aging, vasoactive intestinal peptide, motor activity, circadian phase, circadian rhythm amplitude, hypothalamus
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Circadian Rhythm, Female, Humans, Male, Middle Aged, Motor Activity, Neurons, Suprachiasmatic Nucleus, Vasoactive Intestinal Peptide, Case-Control Studies, Actigraphy
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