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Validation of clinical diagnostic criteria for Alzheimer's disease
Abstract
Clinical investigations of Alzheimer's disease (AD) have been limited by diagnostic inaccuracy. We employed explicit clinical inclusion and exclusion criteria to identify subjects with senile dementia of the Alzheimer type (SDAT). In a consecutive series of 26 postmortem examinations from this sample, AD was histologically verified in all subjects and was the primary dementing illness. Seventeen of the 26 SDAT subjects had been diagnosed when only mildly demented. Two control subjects were examined neuropathologically; AD was absent in both. We conclude that research clinical diagnostic criteria for SDAT, even in its mild stage, are valid.
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Mild senile dementia of the Alzheimer type. 4. Evaluation of intervention
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Reliability of Clinical Nurse Specialists in the Staging of Dementia
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Self-citationAlzheimer's disease and coffee: a quantitative review
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The utility of Stroop task switching as a marker for early-stage Alzheimer's disease.
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Psychopathology of very mild dementia of the Alzheimer type
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Kauwe, J. S. K., Jacquart, S., Chakraverty, S., Wang, J., Mayo, K., Fagan, A. M., Holtzman, D. M., Morris, J. C., & Goate, A. M. (2007) · Annals of Neurology · doi:10.1002/ana.21099 · Cited by 84
Metadata
- Authors
- Morris, J. C., McKeel, D. W., Fulling, K., Torack, R. M., & Berg, L.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Morris, John C.
- ORCID
- Morris, John C.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1988-07
- Volume
- 24
- Issue
- 1
- Pages
- 17-22
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2055629766
- Cited by
- 362
- References
- 31
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 2 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 19.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG03991, AG 05681)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Keywords
- Alzheimer's disease, senile dementia of the Alzheimer type, clinical criteria, diagnostic accuracy, mild dementia, postmortem neuropathology, histopathological confirmation, underdiagnosis of dementia
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebral Infarction, Diagnosis, Differential, Female, Humans, Male, Neuropsychological Tests
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