The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Open accessAbstract
This study investigated cerebral glucose metabolism in very early Alzheimer's disease, before a clinical diagnosis of probable Alzheimer's disease is possible, using [18 F]fluorodeoxyglucose positron emission tomography. First, 66 patients with probable Alzheimer's disease with a spectrum of dementia severity (Mini‐Mental State Examination score, 0–23) were recruited and studied. Cortical metabolic activity was analyzed topographically using three‐dimensional stereotactic surface projections. Regression analysis was performed for each brain pixel to predict metabolic patterns of very early disease. Predictions were tested prospectively in a group of 8 patients who complained only of memory impairment without general cognitive decline (Mini‐Mental State Examination score, 25 · 1) at the time of scanning but whose condition later progressed to probable Alzheimer's disease. Both results were compared to cerebral metabolic activity in 22 age‐similar normal control subjects. Prediction and analysis of actual patients consistently indicated marked metabolic reduction (21–22%) in the posterior cingulate cortex and cinguloparietal transitional area in patients with very early Alzheimer's disease. Mean metabolic reduction in the posterior cingulate cortex was significantly greater than that in the lateral neocortices or parahippocampal cortex. The result suggests a functional importance for the posterior cingulate cortex in impairment of learning and memory, which is a feature of very early Alzheimer's disease.
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“Compelling evidence links neurodegeneration to altered brain metabolism and mitochondrial dysfunction, both of which are early hallmarks of AD [21–28].”
From Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function (2019) · cites this paper as [21]
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In the citing paper
“Instead, in the very early phases of AD, a significant loss of σ1R occurs in the brain [115,116].”
From Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies (2023) · cites this paper as [116]
Experimental — accuracy not yet measuredIn the citing paper
“The precuneus region, which is known to be an area of early deposition in both sporadic Alzheimer’s disease and autosomal dominant Alzheimer’s disease,4,23,24 was chosen for analysis of amyloid deposition.”
From Clinical and biomarker changes in dominantly inherited Alzheimer's disease (2012) · cites this paper as [23]
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“Finally, we note the selective vulnerability of the posterior cingulate and precuneus in such conditions as carbon monoxide poisoning [i.e., acute hypoxia (34)], diffuse brain ischemia (35), and Alzheimer's disease (32).”
From A default mode of brain function (2001) · cites this paper as [32]
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“Furthermore, patients with Alzheimer's disease show early reductions of metabolic activity in this area (32) and have been reported to show abnormalities in the processing of extrafoveal information (33).”
From A default mode of brain function (2001) · cites this paper as [32]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Wechsler Adult Intelligence Scale
(2007) · Sage eBooks · doi:10.4135/9781412952644.n478 · Cited by 2,017
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380
Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366
Self-citationVogt, B. A., Finch, D. M., & Olson, C. R. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.6.435-a · Cited by 1,315
Flagged first, then by citations
Research works printed but not linked: 3
- Benton AL, 1974, The Revised Visual Retention Test
- Foster NL, 1995, Metabolic topography of progressive limbic lobe sclerosis, J Cereb Blood Flow Metab, 15, S818
- Vander Borght TM, 1995, Is regional cerebral glucose metabolism different between Alzheimer's and Parkinson's disease dementia with similar dementia severity?, J Cereb Blood Flow Metab, 15, S788
Cited by
Sorted by citations
Items 101–133 of 133
Shah, T., Verdile, G., Sohrabi, H., Campbell, A., Putland, E., Cheetham, C., Dhaliwal, S., Weinborn, M., Maruff, P., Darby, D., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.122 · Cited by 94
Staffaroni, A., Elahi, F., McDermott, D., Marton, K., Karageorgiou, E., Sacco, S., Paoletti, M., Caverzasi, E., Hess, C., Rosen, H., et al. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1608808 · Cited by 91
Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies
Buccellato, F. R., D’Anca, M., Tartaglia, G. M., Del Fabbro, M., Scarpini, E., & Galimberti, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813900 · Cited by 94
“Instead, in the very early phases of AD, a significant loss of σ 1R occurs in the brain [115,116].”
BackgroundAcetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update
Pennisi, M., Lanza, G., Cantone, M., D’Amico, E., Fisicaro, F., Puglisi, V., Vinciguerra, L., Bella, R., Vicari, E., & Malaguarnera, G. (2020) · Nutrients · doi:10.3390/nu12051389 · Cited by 87
Womack, K. B., Diaz-Arrastia, R., Aizenstein, H. J., Arnold, S. E., Barbas, N. R., Boeve, B. F., Clark, C. M., DeCarli, C. S., Jagust, W. J., Leverenz, J. B., et al. (2011) · Archives of Neurology · doi:10.1001/archneurol.2010.295 · Cited by 85
Self-citationets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons
Helguera, P., Pelsman, A., Pigino, G., Wolvetang, E., Head, E., & Busciglio, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5107-04.2005 · Cited by 88
Bai, F., Watson, D. R., Shi, Y., Wang, Y., Yue, C., YuhuanTeng, Wu, D., Yuan, Y., & Zhang, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024271 · Cited by 85
Altered glucose metabolism in the hippocampal head in memory impairment
Ouchi, Y., Nobezawa, S., Okada, H., Yoshikawa, E., Futatsubashi, M., & Kaneko, M. (1998) · Neurology · doi:10.1212/wnl.51.1.136 · Cited by 85
Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
Wan, W., Cao, L., Kalionis, B., Murthi, P., Xia, S., & Guan, Y. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00607 · Cited by 84
2- 18 F-fluoro-2-deoxyglucose positron emission tomography in delirium
Haggstrom, L. R., Nelson, J. A., Wegner, E. A., & Caplan, G. A. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17701764 · Cited by 78
Pihlajamäki, M., & Sperling, R. A. (2009) · Behavioural Neurology · doi:10.1155/2009/276384 · Cited by 102
Subregional volume reduction of the cholinergic forebrain in subjective cognitive decline (SCD)
Scheef, L., Grothe, M. J., Koppara, A., Daamen, M., Boecker, H., Biersack, H., Schild, H. H., Wagner, M., Teipel, S., & Jessen, F. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.101612 · Cited by 63
Cerebral blood flow changes during chanting meditation.
Khalsa, D. S., Amen, D., Hanks, C., Money, N., & Newberg, A. (2009) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e32832fa26c · Cited by 69
Causal evidence of performance monitoring by neurons in posterior cingulate cortex during learning
Heilbronner, S. R., & Platt, M. L. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.028 · Cited by 66
Rebelos, E., Rinne, J. O., Nuutila, P., & Ekblad, L. L. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071532 · Cited by 66
Apathy as a feature of prodromal Alzheimer's disease: an FDG-PET ADNI study
Delrieu, J., Desmidt, T., Camus, V., Sourdet, S., Boutoleau‐Bretonnière, C., Mullin, E., Vellas, B., Payoux, P., Lebouvier, T., & Initiative, A. D. N. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4161 · Cited by 66
Sreekumar, V., Nielson, D. M., Smith, T. A., Dennis, S. J., & Sederberg, P. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-32879-0 · Cited by 64
Vogt, B. A., Vogt, L. J., Vrana, K. E., Gioia, L., Meadows, R. S., Challa, V. R., Hof, P. R., & Van Hoesen, G. W. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6852 · Cited by 64
Daulatzai, M. A. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1404-6 · Cited by 63
Smailagic, N., Lafortune, L., Kelly, S., Hyde, C., & Brayne, C. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-171125 · Cited by 61
Area-Gomez, E., Larrea, D., Pera, M., Agrawal, R. R., Guilfoyle, D. N., Pirhaji, L., Shannon, K., Arain, H. A., Ashok, A., Chen, Q., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61142-8 · Cited by 55
Förster, S., Buschert, V. C., Teipel, S. J., Friese, U., Buchholz, H.-G., Drzezga, A., Hampel, H., Bartenstein, P., & Buerger, K. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-0025 · Cited by 54
Shokouhi, S., Claassen, D., Kang, H., Ding, Z., Rogers, B., Mishra, A., Riddle, W. R., & Initiative, F. T. A. D. N. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.116137 · Cited by 54
“Regions include cerebellum (1); midbrain (2); pons (3); occipital lobe (4); cingulate cortex (5); sublobar region (6) including corpus callosum, caudate, putamen, globus pallidus, thalamus, and right and left frontal lobes (7, 8); right and left parietal lobes (9, 10); and right and left temporal lobes (11, 12).”
BackgroundMathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., Wharton, S. B., & on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · PLOS ONE · doi:10.1371/journal.pone.0118463 · Cited by 52
Gaitán, J. M., Boots, E. A., Dougherty, R. J., Oh, J. M., Ma, Y., Edwards, D. F., Christian, B. T., Cook, D. B., & Okonkwo, O. C. (2019) · Brain Plasticity · doi:10.3233/bpl-190093 · Cited by 49
Effects of age on the glucose metabolic changes in mild cognitive impairment
Kantarci, K., Senjem, M. L., Lowe, V. J., Wiste, H. J., Weigand, S. D., Kemp, B. J., Frank, A. R., Shiung, M. M., Boeve, B. F., Knopman, D. S., et al. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2070 · Cited by 47
Mirkin, S., & Albensi, B. C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1094233 · Cited by 46
Magnetic resonance and PET studies in the early diagnosis of Alzheimer’s disease
Mosconi, L., De Santi, S., Rusinek, H., Convit, A., & de Leon, M. J. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.5.831 · Cited by 46
Badea, A., Kane, L., Anderson, R. J., Qi, Y., Foster, M., Cofer, G. P., Medvitz, N., Buckley, A. F., Badea, A. K., Wetsel, W. C., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.08.014 · Cited by 39
Staging Neurodegenerative Disorders: Structural, Regional, Biomarker, and Functional Progressions
Archer, T., Kostrzewa, R. M., Beninger, R. J., & Palomo, T. (2011) · Neurotoxicity Research · doi:10.1007/s12640-010-9190-2 · Cited by 34
Tovar-Moll, F., de Oliveira-Souza, R., Bramati, I. E., Zahn, R., Cavanagh, A., Tierney, M., Moll, J., & Grafman, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102656 · Cited by 30
Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease—From Brain Starch to Bench and Bedside
Pawlowski, M., Meuth, S., & Duning, T. (2017) · Diagnostics · doi:10.3390/diagnostics7030042 · Cited by 25
Clinical impact of a second FDG-PET in atypical/unclear dementia syndromes
Bergeron, D., Beauregard, J.-M., Guimond, J., Fortin, M.-P., Houde, M., Poulin, S., Verret, L., Bouchard, R. W., & Laforce, R. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150302 · Cited by 17
Metadata
- Authors
- Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E.
- Affiliations
- University of Michigan (US)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1997-07
- Volume
- 42
- Issue
- 1
- Pages
- 85-94
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2144631174
- Cited by
- 1,802
- References
- 68
- Citations by year
- 2026: 45 · 2025: 53 · 2024: 38 · 2023: 41 · 2022: 42 · 2021: 65 · 2020: 67 · 2019: 62 · 2018: 61 · 2017: 74 · 2016: 83 · 2015: 81 · 2014: 93 · 2013: 76 · 2012: 66
- FWCI
- 17.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- U.S. Department of Energy (DE‐FG02‐)
- University of Michigan
- National Institutes of Health (5r01ns024896-15, 1p30ag008808-01)
- National Institute on Aging (P50AG008671, P30 AG08808, P50 AG08671)
- National Institute of Neurological Disorders and Stroke (R01 NS24896)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, posterior cingulate cortex, brain glucose metabolism, FDG-PET, memory impairment, dementia severity, disease progression prediction, learning and memory
- MeSH terms
- Aged, Alzheimer Disease, Cognition, Deoxyglucose, Energy Metabolism, Female, Glucose, Gyrus Cinguli, Humans, Male, Memory, Prospective Studies, Psychiatric Status Rating Scales, Stereotaxic Techniques, Time Factors, Tissue Distribution, Tomography, Emission-Computed, Radiopharmaceuticals, Fluorodeoxyglucose F18
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