Cited by 144Neural and Behavioral Psychology StudiesAdvanced MRI Techniques and ApplicationsMotor Control and Adaptation

Functional magnetic resonance imaging of single motor events reveals human presupplementary motor area

Humberstone, Miles, Sawle, Guy V., Clare, Stuart, Hykin, Jonathan, Coxon, Ronald, Bowtell, Richard, Macdonald, Ian A., Morris, Peter G.·1997·Annals of Neurology

Abstract

Conventional functional imaging paradigms use periods of repetitive task performance to generate sustained functional signal changes. We have developed a technique of imaging the small, transient signal changes that occur after single cognitive events. The technique uses echo‐planar imaging at 3 T to generate functional images of the whole brain with a temporal resolution of 3 seconds. It uses a signal averaging technique to create time sweeps of functional activity. After a single cognitive event, widely distributed patterns of brain activation can be detected and their time course measured. This technique enables the individual cognitive tasks that constitute a paradigm to be analyzed separately and compared. We describe the application of this new technique to separate the cognitive elements in a simple “go/no‐go” motor paradigm. Comparison of activation patterns during “go” and “no‐go” responses reveals hierarchical subdivision of the medial premotor cortex into an anterior region (presupplementary motor area) involved in movement decision making and a posterior region (supplementary motor area proper) directly involved in motor execution.

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Crossref · 10.1002/ana.410420414

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Authors
Humberstone, M., Sawle, G. V., Clare, S., Hykin, J., Coxon, R., Bowtell, R., Macdonald, I. A., & Morris, P. G.
Affiliations
University of Nottingham (GB)
Corresponding author
Morris, Peter G.
Venue
Annals of Neurology
Publisher
Wiley
Published
1997-10
Volume
42
Issue
4
Pages
632-637
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2000588494
Cited by
144
References
25
Citations by year
2025: 2 · 2024: 1 · 2023: 4 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 2
FWCI
7.03
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Keywords
pre-supplementary motor area, supplementary motor area, echo planar imaging, signal averaging, go/no-go task, motor execution, motor control
MeSH terms
Adult, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Motor Cortex, Psychomotor Performance, Evoked Potentials, Motor

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