Functional magnetic resonance imaging of single motor events reveals human presupplementary motor area
Abstract
Conventional functional imaging paradigms use periods of repetitive task performance to generate sustained functional signal changes. We have developed a technique of imaging the small, transient signal changes that occur after single cognitive events. The technique uses echo‐planar imaging at 3 T to generate functional images of the whole brain with a temporal resolution of 3 seconds. It uses a signal averaging technique to create time sweeps of functional activity. After a single cognitive event, widely distributed patterns of brain activation can be detected and their time course measured. This technique enables the individual cognitive tasks that constitute a paradigm to be analyzed separately and compared. We describe the application of this new technique to separate the cognitive elements in a simple “go/no‐go” motor paradigm. Comparison of activation patterns during “go” and “no‐go” responses reveals hierarchical subdivision of the medial premotor cortex into an anterior region (presupplementary motor area) involved in movement decision making and a posterior region (supplementary motor area proper) directly involved in motor execution.
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From Right hemispheric dominance of inhibitory control: An event-related functional MRI study (1999) · cites this paper as [9]
Cites
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058 · see citing works
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., & Turner, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5675 · Cited by 4,212 · see citing works
Motor Areas of the Medial Wall: A Review of Their Location and Functional Activation
Picard, N., & Strick, P. L. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.342 · Cited by 1,712 · see citing works
Supplementary motor area and other cortical areas in organization of voluntary movements in man
Roland, P. E., Larsen, B., Lassen, N. A., & Skinhöj, E. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.1.118 · Cited by 1,517 · see citing works
Self-initiated versus externally triggered movements
Jahanshahi, M., Jenkins, I. H., Brown, R. G., MARSDEN, C. D., Passingham, R. E., & Brooks, D. J. (1995) · Brain · doi:10.1093/brain/118.4.913 · Cited by 999 · see citing works
The Frontal Lobes and Voluntary Action
Passingham, R. (1993) · doi:10.1093/oso/9780198521853.001.0001 · Cited by 970 · see citing works
Functional magnetic resonance imaging of complex human movements
Rao, S. M., Binder, J. R., Bandettini, P. A., Hammeke, T. A., Yetkin, F. Z., Jesmanowicz, A., Lisk, L. M., Morris, G. L., Mueller, W. M., Estkowski, L. D., et al. (1993) · Neurology · doi:10.1212/wnl.43.11.2311 · Cited by 828 · see citing works
Corticocortical connections of area F3 (SMA‐proper) and area F6 (pre‐SMA) in the macaque monkey
Luppino, G., Matelli, M., Camarda, R., & Rizzolatti, G. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903380109 · Cited by 795 · see citing works
Alexander, G. E., & Crutcher, M. D. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.64.1.133 · Cited by 750 · see citing works
Echo-Planar Imaging: Magnetic Resonance Imaging in a Fraction of a Second
Stehling, M. K., Turner, R., & Mansfield, P. (1991) · Science · doi:10.1126/science.1925560 · Cited by 623 · see citing works
Regional cerebral blood flow during voluntary arm and hand movements in human subjects
Colebatch, J. G., Deiber, M., Passingham, R. E., Friston, K. J., & Frackowiak, R. S. J. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.65.6.1392 · Cited by 603 · see citing works
Shibasaki, H., Sadato, N., Lyshkow, H., Yonekura, Y., Honda, M., Nagamine, T., Suwazono, S., Magata, Y., Ikeda, A., Miyazaki, M., et al. (1993) · Brain · doi:10.1093/brain/116.6.1387 · Cited by 520 · see citing works
Matsuzaka, Y., Aizawa, H., & Tanji, J. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.3.653 · Cited by 500 · see citing works
Menon, R. S., Ogawa, S., Hu, X. P., Strupp, J., Anderson, P., & Uǧurbil, K. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330323 · Cited by 421 · see citing works
Fox, P. T., Fox, J. M., Raichle, M. E., & Burde, R. M. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.2.348 · Cited by 410 · see citing works
Orgogozo, J. M., & Larsen, B. (1979) · Science · doi:10.1126/science.493986 · Cited by 346 · see citing works
Kawashima, R., Yamada, K., Kinomura, S., Yamaguchi, T., Matsui, H., Yoshioka, S., & Fukuda, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)90006-9 · Cited by 267 · see citing works
Zilles, K., Gottfried Schlaug, A., Matelli, M., Luppino, G., Schleicher, A., Qü, M., Dabringhaus, A., Seitz, R. J., & Roland, P. E. (1995) · PubMed · Cited by 232 · see citing works
Boecker, H., Kleinschmidt, A. K., Requardt, M., et al. (1994) · Brain · doi:10.1093/brain/117.6.1231 · Cited by 170 · see citing works
Rémy, P., Zilbovicius, M., Leroy‐Willig, A., Syrota, A., & Samson, Y. (1994) · Annals of Neurology · doi:10.1002/ana.410360107 · Cited by 128 · see citing works
Tyszka, J. M., Grafton, S. T., Chew, W., Woods, R. P., & Colletti, P. M. (1994) · Annals of Neurology · doi:10.1002/ana.410350617 · Cited by 124 · see citing works
Reversible go–no go deficits in a case of frontal lobe tumor
Leimkuhler, M. E., & Mesulam, M. ‐. (1985) · Annals of Neurology · doi:10.1002/ana.410180518 · Cited by 114 · see citing works
Ikeda, A., Lüders, H. O., Collura, T. F., Burgess, R. C., Morris, H. H., Hamano, T., & Shibasaki, H. (1996) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(95)00239-1 · Cited by 105 · see citing works
Echo-Planar Imaging of the Brain at 3.0 T
Mansfield, P., Coxon, R., & Glover, P. M. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199405000-00001 · Cited by 55 · see citing works
Self-citationFunctional brain imaging using EPI at 3 T
Hykin, J., Bowtell, R. W., Mansfield, P., et al. (1994) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/bf01705268 · Cited by 5 · see citing works
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Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921 · see citing works
Right hemispheric dominance of inhibitory control: An event-related functional MRI study
Garavan, H., Ross, T. J., & Stein, E. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8301 · Cited by 1,394 · see citing works
Menzies, L., Chamberlain, S. R., Laird, A. R., Thelen, S. M., Sahakian, B. J., & Bullmore, E. T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.09.005 · Cited by 1,190 · see citing works
Rubia, K., Russell, T., Overmeyer, S., Brammer, M. J., Bullmore, E. T., Sharma, T., Simmons, A., Williams, S. C. R., Giampietro, V., Andrew, C. M., et al. (2001) · NeuroImage · doi:10.1006/nimg.2000.0685 · Cited by 999 · see citing works
Response Inhibition and Response Selection: Two Sides of the Same Coin
Mostofsky, S. H., & Simmonds, D. J. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20500 · Cited by 514 · see citing works
Neurocognitive endophenotypes of obsessive-compulsive disorder
Menzies, L., Achard, S., Chamberlain, S. R., Fineberg, N., Chen, C.-H., del Campo, N., Sahakian, B. J., Robbins, T. W., & Bullmore, E. (2007) · Brain · doi:10.1093/brain/awm205 · Cited by 443 · see citing works
Effects of focal frontal lesions on response inhibition
Picton, T. W., Stuss, D. T., Alexander, M. P., Shallice, T., Binns, M. A., & Gillingham, S. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk031 · Cited by 387 · see citing works
The functional anatomy of auditory hallucinations in schizophrenia
Lennox, B. R., Park, S. B. G., Medley, I., Morris, P. G., & Jones, P. B. (2000) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00068-8 · Cited by 277 · see citing works
Self-citationThe cerebral correlates of set-shifting: an fMRI study of the trail making test
Moll, J., Oliveira-Souza, R. D., Moll, F. T., Bramati, I. E., & Andreiuolo, P. A. (2002) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2002000600002 · Cited by 258 · see citing works
Functional modularity of the medial prefrontal cortex: involvement in human empathy
Seitz, R. J., Nickel, J., & Azari, N. P. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.6.743 · Cited by 194 · see citing works
Cunnington, R., Windischberger, C., & Moser, E. (2005) · Human Movement Science · doi:10.1016/j.humov.2005.10.001 · Cited by 159 · see citing works
Marzuki, A. A., Pereira de Souza, A. M. F. L., Sahakian, B. J., & Robbins, T. W. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.010 · Cited by 39 · see citing works
- Authors
- Humberstone, M., Sawle, G. V., Clare, S., Hykin, J., Coxon, R., Bowtell, R., Macdonald, I. A., & Morris, P. G.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Morris, Peter G.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1997-10
- Volume
- 42
- Issue
- 4
- Pages
- 632-637
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2000588494
- Cited by
- 144
- References
- 25
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- pre-supplementary motor area, supplementary motor area, echo planar imaging, signal averaging, go/no-go task, motor execution, motor control
- MeSH terms
- Adult, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Motor Cortex, Psychomotor Performance, Evoked Potentials, Motor
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