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Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for In Vivo High‐Contrast Bioimaging and Multiplexed Biosensing

Lei, Zuhai, Sun, Caixia, Pei, Peng, Wang, Shangfeng, Li, Dandan, Zhang, Xin, Zhang, Fan·2019·Angewandte Chemie

Abstract

Small‐molecule organic fluorophores, spectrally active in the 900–1700 nm region, with tunable wavelength and sensing properties are sought‐after for in vivo optical imaging and biosensing. A panel of fluorescent dyes (CX) has been developed to meet this challenge. CX dyes exhibit the wavelength tunability of cyanine dyes and have a rigidified polymethine chain to guarantee their stability. They are chemo‐ and photo‐stable in an aqueous environment and have tunable optical properties with maximal absorbing/emitting wavelength at 1089/1140 nm. They show great potential in high‐contrast in vivo bioimaging and multicolor detection with negligible optical cross talk. Förster resonance energy transfer (FRET) between CX dyes was demonstrated in deep tissue, providing an approach for monitoring drug‐induced hepatotoxicity by detection of OONO−. This report presents a series of NIR‐II dyes with promising spectroscopic properties for high‐contrast bioimaging and multiplexed biosensing.

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Metadata

Authors
Lei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F.
Venue
Angewandte Chemie
Publisher
Wiley
Published
2019-05-08
Volume
131
Issue
24
Pages
8250-8255
ISSN
  • 0044-8249 (ISSN-L)
  • 1521-3757
OpenAlex
W4252056368
Cited by
208
References
8
FWCI
15.80
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for In Vivo High‐Contrast Bioimaging and Multiplexed Biosensing. https://app.cochat.ai/papers/10.1002/ange.201904182
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Lei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F. (2019). Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for In Vivo High‐Contrast Bioimaging and Multiplexed Biosensing. Angewandte Chemie. https://doi.org/10.1002/ange.201904182

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