The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Controlling the Stealth Effect of Nanocarriers through Understanding the Protein Corona
Abstract
The past decade has seen a significant increase in interest in the use of polymeric nanocarriers in medical applications. In particular, when used as drug vectors in targeted delivery, nanocarriers could overcome many obstacles for drug therapy. Nevertheless, their application is still impeded by the complex composition of the blood proteins covering the particle surface, termed the protein corona. The protein corona complicates any prediction of cell interactions, biodistribution, and toxicity. In particular, the unspecific uptake of nanocarriers is a major obstacle in clinical studies. This Minireview provides an overview of what we currently know about the characteristics of the protein corona of nanocarriers, with a focus on surface functionalization that reduces unspecific uptake (the stealth effect). The ongoing improvement of nanocarriers to allow them to meet all the requirements necessary for successful application, including targeted delivery and stealth, are further discussed.
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Cited by
Controlling the biodistribution and clearance of nanomedicines
Cabral, H., Li, J., Miyata, K., & Kataoka, K. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00138-1 · Cited by 303
Nanoparticle protein corona: from structure and function to therapeutic targeting
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Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine
Ren, J., Andrikopoulos, N., Velonia, K., Tang, H., Cai, R., Ding, F., Ke, P. C., & Chen, C. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c02277 · Cited by 284
The protein corona and its effects on nanoparticle-based drug delivery systems
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Metallodrugs in cancer nanomedicine
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Metadata
- Authors
- Schöttler, S., Landfester, K., & Mailänder, V.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2016-06-15
- Volume
- 55
- Issue
- 31
- Pages
- 8806-8815
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2425407891
- Cited by
- 291
- References
- 14
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- closed
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