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Cited by 295

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

The somatic mutation theory of cancer: growing problems with the paradigm?

Soto, Ana M., Sonnenschein, Carlos·2004·BioEssays
DOI 10.1002/bies.20087
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Abstract

The somatic mutation theory has been the prevailing paradigm in cancer research for the last 50 years. Its premises are: (1) cancer is derived from a single somatic cell that has accumulated multiple DNA mutations, (2) the default state of cell proliferation in metazoa is quiescence, and (3) cancer is a disease of cell proliferation caused by mutations in genes that control proliferation and the cell cycle. From this compelling simplicity, an increasingly complicated picture has emerged as more than 100 oncogenes and 30 tumor suppressor genes have been identified. To accommodate this complexity, additional ad hoc explanations have been postulated. After a critical review of the data gathered from this perspective, an alternative research program has been proposed. It is based on the tissue organization field theory, the premises of which are that carcinogenesis represents a problem of tissue organization, comparable to organogenesis, and that proliferation is the default state of all cells. The merits of these competing theories are evaluated herein. BioEssays 26:1097–1107, 2004. © 2004 Wiley Periodicals, Inc.

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Metadata

Authors
Soto, A. M., & Sonnenschein, C.
Venue
BioEssays
Publisher
Wiley
Published
2004-09-20
Volume
26
Issue
10
Pages
1097-1107
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
DOI
10.1002/bies.20087
OpenAlex
W2035238501
Cited by
295
References
71
FWCI
0.97
Type
journal article
Language
en
Open access
closed

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