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Luteolin as a modulator of skin aging and inflammation

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Gendrisch, Fabian, Esser, Philipp R., Schempp, Christoph M., Wölfle, Ute·2021·BioFactors

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Abstract

Luteolin belongs to the group of flavonoids and can be found in flowers, herbs, vegetables and spices. It plays an important role in defending plants, for example against UV radiation by partially absorbing UVA and UVB radiation. Thus, luteolin can also decrease adverse photobiological effects in the skin by acting as a first line of defense. Furthermore, anti‐oxidative and anti‐inflammatory activities of luteolin were described on keratinocytes and fibroblasts as well as on several immune cells (e.g., macrophages, mast cell, neutrophils, dendritic cells and T cells). Luteolin can suppress proinflammatory mediators (e.g., IL‐1β, IL‐6, IL‐8, IL‐17, IL‐22, TNF‐α and COX‐2) and regulate various signaling pathway (e.g., the NF‐κB, JAK–STAT as well as TLR signaling pathway). In this way, luteolin modulates many inflammatory processes of the skin. The present review summarizes the recent in vitro and in vivo research on luteolin in the field of skin aging and skin cancer, wound healing as well as inflammatory skin diseases, including psoriasis, contact dermatitis and atopic dermatitis. In conclusion, luteolin might be a promising molecule for the development of topic formulations and systemic agents against inflammatory skin diseases.

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Wan, D., Fu, Y., Le, Y., Zhang, P., Ju, J., Wang, B., Zhang, G., Wang, Z., Su, H., Wang, L., et al. (2019) · Stem Cells International · doi:10.1155/2019/1575480 · Cited by 25
Topical antioxidants protect the skin from chemical-induced irritation in the repetitive washing test: A placebo-controlled, double-blind study
Schempp, C. M., Meinke, M. C., Lademann, J., Ferrari, Y., Brecht, T., & Gehring, W. (2012) · Contact Dermatitis · doi:10.1111/j.1600-0536.2012.02114.x · Cited by 23
Self-citation
Canine atopic dermatitis: Role of luteolin as new natural treatment
Gugliandolo, E., Palma, E., Cordaro, M., D’Amico, R., Peritore, A. F., Licata, P., & Crupi, R. (2020) · Veterinary Medicine and Science · doi:10.1002/vms3.325 · Cited by 22
Increased cyclooxygenase expression and thymine dimer formation after repeated exposures of humans to low doses of solar simulated radiation
Narbutt, J., Lesiak, A., Jochymski, C., Kozłowski, W., Sysa‐Jędrzejowska, A., & Norval, M. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00598.x · Cited by 11

The macrophage polarization in inflammatory dermatosis and its potential drug candidates
Sun, Q., Hu, S., Lou, Z., & Gao, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114469 · Cited by 66
Potential Role of Polyphenolic Flavonoids as Senotherapeutic Agents in Degenerative Diseases and Geroprotection
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See all 357

Authors: Gendrisch, F., Esser, P. R., Schempp, C. M., & Wölfle, U.
Venue: BioFactors
Publisher: Wiley
Published: 2020-12-25
Volume: 47
Issue: 2
Pages: 170-180
ISSN: 0951-6433 (ISSN-L)
1872-8081
DOI: 10.1002/biof.1699
OpenAlex: W3114154535
Cited by: 357
References: 84
FWCI: 15.46
Type: journal article
Language: en
Open access: hybrid

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Luteolin as a modulator of skin aging and inflammation

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