Cited by 97Stress Responses and CortisolHormonal Regulation and HypertensionRenin-Angiotensin System Studies

Paraventricular nucleus of the human hypothalamus in primary hypertension: Activation of corticotropin-releasing hormone neurons

Goncharuk, Valeri D., Van Heerikhuize, Joop, Swaab, Dick F., Buijs, Ruud M.·2002·Journal of Comparative Neurology

Abstract

By using quantitative immunohistochemical and in situ hybridization techniques, we studied corticotropin-releasing hormone (CRH) -producing neurons of the hypothalamic paraventricular nucleus (PVN) in patients who suffered from primary hypertension and died due to acute cardiac failure. The control group consisted of individuals who had normal blood pressure and died of acute heart failure due to mechanical trauma. Both magno- and parvocellular populations of CRH neurons appeared to be more numerous in the PVN of hypertensive patients. Quantitative analysis showed approximately a twofold increase in the total number of CRH neurons and a more than fivefold increase in the amount of CRH mRNA in the hypertensive PVN compared with the control. It is suggested that synthesis of CRH in hypertensive PVN is enhanced. Increased activity of CRH-producing neurons in the PVN of hypertensive patients is proposed not only to entail hyperactivity of the hypothalamo-pituitary-adrenal axis, but also of the sympathetic nervous system and, thus, to be involved in the pathogenesis of hypertension.

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Crossref · 10.1002/cne.10124

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  • Reduced levels of vasopressin in the SCN could result in disinhibition of CRH production by the PVN and contribute to the abnormal 24-h variation in blood pressure observed in hypertensive patients.

    “Thus, the reduced levels of vasopressin in the SCN could result in disinhibition of CRH production by the PVN and, in turn, contribute to the abnormal 24-h variation in blood pressure observed in these patients (Goncharuk et al., 2002).”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Goncharuk et al., 2002

  • More corticotropin-releasing hormone (CRH) neurons and greater CRH mRNA are present in the paraventricular nucleus of the hypothalamus of people with essential hypertension than controls.

    “At the same time, more corticotropin-releasing hormone (CRH) neurons and greater CRH mRNA are present in the paraventricular nucleus (PVN) of the hypothalamus of people with essential hypertension than controls (Goncharuk et al., 2002).”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Goncharuk et al., 2002

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Authors
Goncharuk, V. D., Van Heerikhuize, J., Swaab, D. F., & Buijs, R. M.
Affiliations
National Medical Research Center of Cardiology (RU)
Corresponding author
Goncharuk, Valeri D.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
2002-01-18
Volume
443
Issue
4
Pages
321-331
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
OpenAlex
W1989195109
Cited by
97
References
116
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 6
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
paraventricular nucleus, hypothalamus, essential hypertension, corticotropin-releasing factor, CRH neurons, CRH mRNA, magnocellular neurons, parvocellular neurons, hypothalamic-pituitary-adrenal axis, sympathetic nervous system, heart failure, hypertension pathogenesis
MeSH terms
Adult, Aged, Corticotropin-Releasing Hormone, Female, Humans, Hypertension, Male, Middle Aged, Neurons, Paraventricular Hypothalamic Nucleus, Statistics, Nonparametric

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