Projections of the suprachiasmatic nucleus to stress-related areas in the rat hypothalamus: A light and electron microscopic study

Buijs, Ruud M.; Markman, Marry; Nunes‐Cardoso, Bob; Hou, Yang‐Xun; Shinn, Susan

doi:10.1002/cne.903350104

Cited by 153Stress Responses and CortisolCircadian rhythm and melatoninHypothalamic control of reproductive hormones

Projections of the suprachiasmatic nucleus to stress-related areas in the rat hypothalamus: A light and electron microscopic study

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Buijs, Ruud M., Markman, Marry, Nunes‐Cardoso, Bob, Hou, Yang‐Xun, Shinn, Susan·1993·Journal of Comparative Neurology

DOI 10.1002/cne.903350104

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Abstract

The purpose of the present study was to investigate the sites in the hypothalamus where the suprachiasmatic nucleus (SCN) may influence corticosteroid secretion. In spite of the well established, SCN-mediated, daily rhythms in adrenocorticotrophic hormone (ACTH) and corticosteroid secretion, previous studies determining the projections of the suprachiasmatic nucleus failed to illustrate direct connections with corticotrophin-releasing hormone neurons (CRH). In order to identify where in the central nervous system the SCN may influence corticosteroid secretion, areas were selected that contained SCN efferents contacting neurons involved in the stress response. To achieve this in the present study, SCN efferents were visualized by Pha-L tract-tracing, together with the neurons involved in the stress response by immunocytochemical staining for c-fos protein. The sites where these efferents contacted c-fos-positive neurons were established by light microscopic double staining and electron microscopic immunocytochemical studies. It appeared that apart from the medial parvocellular area of the paraventricular nucleus (PVN) of the hypothalamus, many more regions showed fos-positive neurons. Sites where SCN efferents contacted such neurons are limited only to areas immediately adjacent to these putative CRH neurons but are not concentrated on these neurons themselves. These areas consist of the periventricular and rostral PVN together with the dorsomedial hypothalamus: all three regions are known to project into the PVN. Therefore, it is concluded that the SCN transmits its information related to corticosteroid secretion via interneurons in and around the PVN to the CRH-containing neurons, rather than by a direct interaction with these neurons themselves.

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The SCN may modulate cardiovascular functioning, as suggested by multisynaptic projections from the SCN to the heart and organs that regulate cardiovascular function through hormones and blood volume regulation.
“That the SCN may modulate cardiovascular functioning is suggested by the presence of multisynaptic projections from the SCN to the heart and organs that regulate cardiovascular function through hormones and blood volume regulation (e.g., adrenal cortex, adrenal medulla, and kidneys”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Buijs et al., 1993
Vasopressinergic neurons from the SCN have an inhibitory effect on CRH neurons in the PVN.
“The vasopressinergic neurons from the SCN have an inhibitory effect on CRH neurons in the PVN (Buijs et al., 1993; Hermes et al., 1996).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Buijs et al., 1993

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Projections of the suprachiasmatic nucleus to stress related areas in the rat hypothalamus: A light and electromicroscopic study using Pha-L tracing and fos immunocytochemistry
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Suprachiasmatic nucleus lesion increases corticosterone secretion
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Chapter 16 The anatomical basis for the expression of circadian rhythms: the efferent projections of the suprachiasmatic nucleus
Buijs, R. M. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)60411-2 · Cited by 62 · see citing works
Self-citation

Authors: Buijs, R. M., Markman, M., Nunes‐Cardoso, B., Hou, Y., & Shinn, S.
Corresponding author: Buijs, Ruud M.
ORCID: Buijs, Ruud M.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1993-09
Volume: 335
Issue: 1
Pages: 42-54
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.903350104
OpenAlex: W2026488175
Cited by: 153
References: 27
Citations by year: 2026: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 5
FWCI: 3.69
Type: journal article
Language: en
Open access: green
pure.knaw.nl
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4056 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: suprachiasmatic nucleus, hypothalamus, corticosteroid secretion, c-fos, paraventricular nucleus, dorsomedial hypothalamus, stress response, daily rhythms, ACTH, interneurons
MeSH terms: Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Animals, Efferent Pathways, Immunohistochemistry, Male, Microscopy, Microscopy, Electron, Neurons, Phytohemagglutinins, Staining and Labeling, Stress, Physiological, Suprachiasmatic Nucleus, Vasoactive Intestinal Peptide, Vasopressins, Proto-Oncogene Proteins c-fos, Rats, Wistar, Rats

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Projections of the suprachiasmatic nucleus to stress-related areas in the rat hypothalamus: A light and electron microscopic study

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