Cited by 169Diabetic Foot Ulcer Assessment and ManagementFoot and Ankle SurgeryWound Healing and Treatments

Guidelines on offloading foot ulcers in persons with diabetes—IWGDF 2023 update.

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Bus, Sicco A., Armstrong, David G., Crews, Ryan T., Gooday, Catherine, Jarl, Gustav, Kirketerp‐Moller, Klaus, Viswanathan, Vijay, Lazzarini, Peter A.·2024·Diabetes/Metabolism Research and Reviews

Abstract

AIMS: Offloading mechanical tissue stress is arguably the most important of multiple interventions needed to heal diabetes-related foot ulcers. This is the 2023 International Working Group on the Diabetic Foot (IWGDF) evidence-based guideline on offloading interventions to promote healing of foot ulcers in persons with diabetes. It serves as an update of the 2019 IWGDF guideline. MATERIALS AND METHODS: We followed the GRADE approach by devising clinical questions and important outcomes in the PICO (Patient-Intervention-Control-Outcome) format, undertaking a systematic review and meta-analyses, developing summary of judgement tables and writing recommendations and rationales for each question. Each recommendation is based on the evidence found in the systematic review, expert opinion where evidence was not available, and a careful weighing of GRADE summary of judgement items including desirable and undesirable effects, certainty of evidence, patient values, resources required, cost effectiveness, equity, feasibility, and acceptability. RESULTS: For healing a neuropathic plantar forefoot or midfoot ulcer in a person with diabetes, use a non-removable knee-high offloading device as the first-choice offloading intervention. If contraindications or patient intolerance to non-removable offloading exist, consider using a removable knee-high or ankle-high offloading device as the second-choice offloading intervention. If no offloading devices are available, consider using appropriately fitting footwear combined with felted foam as the third-choice offloading intervention. If such a non-surgical offloading treatment fails to heal a plantar forefoot ulcer, consider an Achilles tendon lengthening, metatarsal head resection, joint arthroplasty, or metatarsal osteotomy. For healing a neuropathic plantar or apex lesser digit ulcer secondary to flexibile toe deformity, use digital flexor tendon tenotomy. For healing rearfoot, non-plantar or ulcers complicated with infection or ischaemia, further recommendations have been outlined. All recommendations have been summarised in an offloading clinical pathway to help facilitate the implementation of this guideline into clinical practice. CONCLUSION: These offloading guideline recommendations should help healthcare professionals provide the best care and outcomes for persons with diabetes-related foot ulcers and reduce the person's risk of infection, hospitalisation and amputation.

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Crossref · 10.1002/dmrr.3647

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  • A toe systolic blood pressure less than 30 mm Hg had a 2.09 times higher relative risk of a nonhealing wound post-amputation compared with values of 30 mm Hg or greater (95% CI, 1.37-3.20).

    “Another meta-analysis of 4 studies with 104 patients reported that a toe systolic blood pressure less than 30 mm Hg had a 2.09 times higher relative risk (RR) of a nonhealing wound post-amputation compared with values of 30 mm Hg or greater (95% CI, 1.37-3.20;P = .001[absolute rates not provided]).46”

    From Diabetic Foot Ulcers (2023) · cites this paper as [46]

    The surgical-offloading rationale discusses ulcer healing and amputations, but does not report toe systolic pressure or wound healing after amputation. Searches for the 30 mm Hg threshold and the reported relative risk found no passage addressing the claimed meta-analysis. (LLM, conf=0.76)

    Experimental — accuracy not yet measured
  • Toe systolic blood pressure <30 mm Hg is associated with 2.09-fold higher relative risk of nonhealing after partial foot amputation compared with values ≥30 mm Hg (relative risk, 2.09; 95% CI, 1.37-3.20; P =.001).

    “Toe systolic blood pressure <30 mm Hg is associated with 2.09-fold higher relative risk of nonhealing after partial foot amputation compared with values ≥30 mm Hg (relative risk, 2.09; 95% CI, 1.37-3.20;P =.001).”

    From Diabetic Foot Ulcers (2023) · cites this paper as [46]

    The surgical-offloading rationale (page not provided) discusses ulcer healing and amputations after offloading interventions, but not toe systolic blood pressure as a predictor of healing after partial foot amputation. Searches for the 30 mm Hg threshold, the reported relative risk and confidence interval, and toe systolic blood pressure found no passage addressing the claim. (LLM, conf=0.76)

    Experimental — accuracy not yet measured
  • Toe systolic blood pressure measurement is 86% sensitive and 58% specific.

    “Toe systolic blood pressure 46,47 Measurement of systolic blood pressure at the toe 86% sensitive; 58% specific”

    From Diabetic Foot Ulcers (2023) · cites this paper as [46]

    The cited guideline discusses offloading devices and plantar pressure (Below ankle-high offloading device, p. 6), not the diagnostic accuracy of toe systolic blood pressure measurement. Searches for toe systolic blood pressure and the stated 86% sensitivity and 58% specificity found no passage addressing those figures. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 3

  1. Raspovic A, Landorf K. A survey of offloading practices for diabetes- related plantar neuropathic foot ulcers. J Foot Ankle Res. 2014;7(1): 35. https://doi.org/10.1186/s13047-014-0035-8 · DOI · Paper page
  2. Berhane T, Jeyaraman K, Hamilton M, Falhammar H. Pressure relieving interventions for the management of diabetes-related foot ulcers: a study from the Northern Territory of Australia. ANZ J Surg. 2022;92(4):723-729. https://doi.org/10.1111/ans.17431 · DOI
  3. Sahu B, Prusty A, Tudu B. Total contact casting versus traditional dressing in diabetic foot ulcers. J Orthop Surg. 2018;26(3): 230949901880248. https://doi.org/10.1177/2309499018802486 · DOI

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Authors
Bus, S. A., Armstrong, D. G., Crews, R. T., Gooday, C., Jarl, G., Kirketerp‐Moller, K., Viswanathan, V., & Lazzarini, P. A.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • University of Southern California (US)
  • Rosalind Franklin University of Medicine and Science (US)
  • Norfolk and Norwich University Hospital (GB)
  • Örebro University (SE)
  • Copenhagen Wound Healing Center Bispebjerg University Hospital Copenhagen Denmark
  • M.V. Hospital for Diabetes and Diabetes Research Centre (IN)
  • Queensland University of Technology (AU)
Corresponding author
Bus, Sicco A.
Venue
Diabetes/Metabolism Research and Reviews
Publisher
Wiley
Published
2023-05-25
Volume
40
Issue
3
Pages
e3647-e3647
ISSN
  • 1520-7552 (ISSN-L)
  • 1520-7560
OpenAlex
W4378173487
Cited by
169
References
55
Citations by year
2026: 68 · 2025: 50 · 2024: 30 · 2023: 17 · 2022: 3 · 2021: 1
FWCI
33.85
Type
journal article
Language
en
Open access
Locations
  • Diabetes/Metabolism Research and Reviews (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Pure Amsterdam UMC (submittedVersion, other-oa)
Funders
  • Novo Nordisk Fonden (NNF16SA0024126-3)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK124789)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Foot and Ankle Surgery
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
diabetic foot ulcer, offloading, offloading devices, footwear, Achilles tendon lengthening, metatarsal head resection, metatarsal osteotomy, toe deformity, ulcer healing, amputation prevention
MeSH terms
Diabetes Mellitus, Foot, Humans, Ulcer, Wound Healing, Weight-Bearing, Foot Ulcer, Practice Guidelines as Topic, Diabetic Foot, Evidence-Based Medicine

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