Uptake and elimination of perfluorinated phosphonic acids in the rat
Open accessAbstract
The mono- and di-substituted perfluorinated phosphonic acids (mono-PFPAs and di-PFPAs) are high production volume fluorinated surfactants. Mono-PFPAs have been observed in Canadian surface waters and wastewater treatment plant (WWTP) effluent. The first observation of the di-PFPAs in the environment is reported here, with the observation of the C6/C6 and C6/C8 di-PFPAs in the National Institute for Standards and Technology (NIST) WWTP sludge standard reference material (SRM) 2781. To characterize the risk associated with human exposure to the mono-PFPAs and di-PFPAs, we determined uptake and elimination parameters in the rat. After oral gavage all of the mono-PFPA and di-PFPA congeners were observed in the blood of the dosed animals. Half-lives after intraperitoneal dosing ranged from 0.96 ± 0.11 to 2.8 ± 0.5 days for the mono-PFPAs and 1.8 ± 0.1 to 9.3 ± 1.5 days for the di-PFPAs. These half-lives are of similar magnitude to those for perfluorooctane sulfonate (PFOS, 8 to 30 days in male rats) and perfluorooctanoate (PFOA, 6 days in male rats and 1 hour in female rats). Both PFOS and PFOA have human half-lives on the order of years, and so the mono-PFPAs and di-PFPAs may also have significant lifetimes in the human body. The analysis of paired whole blood and plasma samples demonstrated that the mono-PFPAs may bind to blood cells underestimating their concentration in plasma and sera samples. The biological fate of the mono-PFPAs and di-PFPAs determined here suggest there is the potential for human exposure and that if exposure does occur, they may be long-lived in the body. Environ. Toxicol. Chem. 2010;29:1319–1329. © 2010 SETAC
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Certain perfluoroalkyl phosphonic and phosphinic acids (PFPAs and PFPIAs) can only be slowly eliminated from rainbow trout and rats, similarly to long-chain PFCAs and PFSAs.
“For example, certain peruoroalkyl phosphonic and phosphinic acids (PFPAs and PFPIAs) can only be slowly eliminated from rainbow trout 27 and rats, 28 similarly to long-chain PFCAs and PFSAs.29”
From Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health (2020) · cites this paper as [28]
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- Authors
- D'eon, J. C., & Mabury, S. A.
- Affiliations
- Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6 Canada
- University of Toronto (CA)
- Corresponding author
- Mabury, Scott A.
- ORCID
- Mabury, Scott A.
- Venue
- Environmental Toxicology and Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-01
- Volume
- 29
- Issue
- 6
- Pages
- 1319-1329
- ISSN
- 0730-7268 (ISSN-L)
- 1552-8618
- OpenAlex
- W2112656955
- Cited by
- 52
- References
- 37
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 7
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Environmental Toxicology and Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Toronto
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Environmental Chemistry › Environmental Chemistry and Analysis
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- perfluorinated surfactants, tissue distribution, elimination half-life, sewage sludge, human exposure, rat pharmacokinetics, PFOS, perfluorooctanoic acid
- MeSH terms
- Animals, Environmental Monitoring, Female, Humans, Male, Surface-Active Agents, Tissue Distribution, Water Pollutants, Chemical, Rats, Sprague-Dawley, Rats, Halogenation, Organophosphonates
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