Cited by 165Neurogenesis and neuroplasticity mechanismsPI3K/AKT/mTOR signaling in cancerMultiple Sclerosis Research Studies

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Myelination and mTOR

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Figlia, Gianluca, Gerber, Daniel, Suter, Ueli·2018·Glia

DOI 10.1002/glia.23273PMC PMC5836902

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Abstract

Myelinating cells surround axons to accelerate the propagation of action potentials, to support axonal health, and to refine neural circuits. Myelination is metabolically demanding and, consistent with this notion, mTORC1—a signaling hub coordinating cell metabolism—has been implicated as a key signal for myelination. Here, we will discuss metabolic aspects of myelination, illustrate the main metabolic processes regulated by mTORC1, and review advances on the role of mTORC1 in myelination of the central nervous system and the peripheral nervous system. Recent progress has revealed a complex role of mTORC1 in myelinating cells that includes, besides positive regulation of myelin growth, additional critical functions in the stages preceding active myelination. Based on the available evidence, we will also highlight potential nonoverlapping roles between mTORC1 and its known main upstream pathways PI3K‐Akt, Mek‐Erk1/2, and AMPK in myelinating cells. Finally, we will discuss signals that are already known or hypothesized to be responsible for the regulation of mTORC1 activity in myelinating cells.

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Authors: Figlia, G., Gerber, D., & Suter, U.
Affiliations: ETH Zurich (CH)
Corresponding author: Suter, Ueli
ORCID: Figlia, Gianluca
Gerber, Daniel
Suter, Ueli
Venue: Glia
Publisher: Wiley
Published: 2017-12-06
Volume: 66
Issue: 4
Pages: 693-707
ISSN: 0894-1491 (ISSN-L)
1098-1136
DOI: 10.1002/glia.23273
PMC: PMC5836902
OpenAlex: W2772611711
Cited by: 165
References: 155
Citations by year: 2026: 14 · 2025: 19 · 2024: 15 · 2023: 23 · 2022: 18 · 2021: 21 · 2020: 26 · 2019: 15 · 2018: 13
FWCI: 2.23
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Glia (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
ETH Zürich Research Collection (cc-by)
Funders: Swiss National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: myelination, mTORC1, myelinating cells, glial metabolism, cellular metabolism, central nervous system myelination, peripheral nervous system myelination, PI3K/Akt signaling, MEK/ERK signaling, AMPK signaling
MeSH terms: Animals, Humans, Myelin Sheath, TOR Serine-Threonine Kinases

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