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The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

Menon, Suchithra, Dibble, Christian C., Talbott, George, Hoxhaj, Gerta, Valvezan, Alexander J., Takahashi, Hidenori, Cantley, Lewis C., Manning, Brendan D.·2014·Cell
DOI 10.1016/j.cell.2013.11.049PMC PMC4030681
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Crossref · 10.1016/j.cell.2013.11.049

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  • Insulin/PI3K/AKT signaling phosphorylates TSC on multiple residues, causing TSC to depart from the lysosome and permitting Rheb to be loaded by GTP.

    “A number of different factors have been reported to control the lysosomal localization of TSC, most notably insulin/PI3K/AKT signaling, which acts to phosphorylates TSC on multiple residues, causing TSC to depart from the lysosome and permitting Rheb to be loaded by GTP 180.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [180]

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Research works printed but not linked: 39

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  12. Dong, 2004, Tsc2 is not a critical target of Akt during normal Drosophila development, Genes Dev., 18, 2479, 10.1101/gad.1240504 · DOI
  13. Hara, 1998, Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism, J. Biol. Chem., 273, 14484, 10.1074/jbc.273.23.14484 · DOI
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  18. Jacobs, 2013, Eccentric contractions increase TSC2 phosphorylation and alter the targeting of TSC2 and mTOR to the lysosome, J. Physiol., 591, 4611, 10.1113/jphysiol.2013.256339 · DOI · Paper page
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  28. Plas, 2003, Akt activation promotes degradation of tuberin and FOXO3a via the proteasome, J. Biol. Chem., 278, 12361, 10.1074/jbc.M213069200 · DOI
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  33. Wang, 2006, Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1, J. Biol. Chem., 281, 24293, 10.1074/jbc.M603566200 · DOI
  34. Yip, 2010, Structure of the human mTOR complex I and its implications for rapamycin inhibition, Mol. Cell, 38, 768, 10.1016/j.molcel.2010.05.017 · DOI · Paper page
  35. Zhang, 2009, Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway, PLoS ONE, 4, e6189, 10.1371/journal.pone.0006189 · DOI
  36. Albertti, 2010, Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development, Microbes Infect., 12, 784, 10.1016/j.micinf.2010.05.015 · DOI
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Metadata

Authors
Menon, S., Dibble, C. C., Talbott, G., Hoxhaj, G., Valvezan, A. J., Takahashi, H., Cantley, L. C., & Manning, B. D.
Venue
Cell
Publisher
Elsevier BV
Published
2014-02
Volume
156
Issue
4
Pages
771-785
ISSN
0092-8674
DOI
10.1016/j.cell.2013.11.049
PMC
PMC4030681
Cited by
766
References
12
Language
en
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